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15,733 results for “article”
Dataset related to article "Hypofractionated Whole Breast Irradiation and Simultaneous Integrated Boost in Large-breasted Patients: Long-term Toxicity and Cosmesis"s
<p>This record contains data related to article "Hypofractionated Whole Breast Irradiation and Simultaneous Integrated Boost in Large-breasted Patients: Long-term Toxicity and Cosmesis"</p> <p>Abstract</p> <p><strong>Introduction: </strong>The purpose of this study was to evaluate the impact of breast size on long-term toxicity and cosmesis in patients with breast cancer treated with hypofractionated simultaneous integrated boost (SIB) using volumetric modulated arc therapy (VMAT).</p> <p><strong>Patients and methods: </strong>Patients with early stage breast cancer were treated with 3-week hypofractionated SIB-VMAT to the whole breast (40.5 Gy) and tumor bed (48 Gy). Two cohorts were identified: small/medium- (< 1000 cm<sup>3</sup>) and large- (> 1000 cm<sup>3</sup>) breasted patients. Acute and late (at 2 and 5 years) skin toxicity and cosmetic data were analyzed. Univariate and multivariate analysis evaluated associations between toxicity and dosimetric/anatomical variables.</p> <p><strong>Results: </strong>From August 2010 to March 2017, a total of 1160 patients were treated; 831 had at least 2 years of follow-up and were analyzed. Treated skin area (TSA) receiving at least 20 Gy > 400 cm<sup>2</sup> and V<sub>105% of Boost</sub> > 5 cm<sup>3</sup> were significant predictors for acute skin toxicity. Multivariate analysis at 2 years was significant for boost volume > 70 cm<sup>3</sup>, TSA > 400 cm<sup>2</sup>, and breast size > 1500 cm<sup>3</sup>. At 5 year analysis (352 patients), none of the analyzed variables was significant. For cosmetic outcome, only the breast size (> 1000 cm<sup>3</sup>) and the boost size > 70 cm<sup>3</sup> at 2 and 5 years, respectively, confirmed significance.</p> <p><strong>Conclusions: </strong>The TSA > 400 cm<sup>2</sup> resulted as a significant predictor of both acute and late skin toxicity at 2 years; however, at 5 years, no breast size or dosimetric parameter suggested indications for increased toxicity. A worse cosmetic outcome was recorded at the 2-year follow up for large breasts, but was not confirmed at the 5-year follow-up. These long-term data suggest that hypofractionated SIB-VMAT is a viable modality also in large-breasted patients.</p>
Dataset related to article "Impact of age on postsurgical outcomes of nonfunctioning pituitary adenomas"
<p>This record contains data related to article "Impact of age on postsurgical outcomes of nonfunctioning pituitary adenomas"</p> <p>Abstract</p> <p><strong>Purpose: </strong> The management of pituitary adenomas in the elderly has become a relevant clinical issue, in relationship with improved life expectancy and spreading use of imaging techniques. In this single-center and retrospective study, we investigated the impact of age on peri- and postsurgical outcomes in patients undergoing transnasal sphenoidal (TNS) surgery for pituitary adenomas.</p> <p><strong>Methods: </strong> One-hundred-sixty-nine patients (62% males) undergoing endoscopic transphenoidal (TNS) surgery for nonfunctioning pituitary adenomas (NFPAs) were enrolled. Patients were subdivided into three groups according to age tertiles: ≤56 (group 1), 57-69 (group 2), and ≥70 (group 3) years. Postsurgical and endocrinological outcomes were evaluated and compared among the three age groups.</p> <p><strong>Results: </strong> 37/169 patients (21.9%) developed at least one perisurgical complication, without significant association with the patients' age (P = 0.838), Charlson co-morbidity score (P = 0.326), and American Society of Anesthesiologist score (P = 0.616). In the multivariate regression analysis, the adenoma size resulted the only determinant of perisurgical complication (odds ratio [OR] 1.07, 95% confidence interval [C.I.] 1.00-1.13; P = 0.044). The development and the recovery of at least one pituitary hormone deficiency were observed in 12.2% and 14.2% of patients, respectively. The risk of developing new pituitary hormone deficiencies was correlated with cavernous sinus invasion as evaluated by magnetic resonance imaging (hazard ratio [HR] 4.19, 95% C.I. 1.39-12.66; P = 0.010), whereas the probability to normalize at least one pituitary hormone deficiency was significantly correlated with younger age of patients (HR 0.27, 95% CI 0.12-0.61; P = 0.002).</p> <p><strong>Conclusions: </strong> The results of this study reinforce the concept that endoscopic TNS surgery is a safe therapeutic option in the elderly patients with NFPA, even in presence of comorbidities and high anesthetic risk.</p>
Dataset related to article "Enhanced Recovery After Pancreatic Surgery Does One Size Really Fit All? A Clinical Score to Predict the Failure of an Enhanced Recovery Protocol After Pancreaticoduodenectomy"
<p>This record contains data related to article “Enhanced Recovery After Pancreatic Surgery Does One Size Really Fit All? A Clinical Score to Predict the Failure of an Enhanced Recovery Protocol After Pancreaticoduodenectomy”.</p>
Supporting data for the article-The colexification of vision and cognition in Mandarin: Controlled activity surpasses uncontrolled experience
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A Dataset and supplementary materials for the article ''Energy poverty and fiscal ressource'' submited in International Tax and Public Finance.
<p>We have two version of dataset, excel and stata with the supplementary materials of the articles which contain colour figures and tables.</p>
Dataset related to article"Integrating single-cell and spatial transcriptomics to elucidate the crosstalk between cancer-associated fibroblasts and cancer cells in hepatocellular carcinoma with spleen-deficiency syndrome"
<p>Most patients with hepatocellular carcinoma (HCC) in China have been diagnosed with spleen deficiency syndrome (SDS), which accelerates the progression of HCC by disrupting the tumor microenvironment (TME) homeostasis. However, the underlying mechanism remains to be explored. By integrating single-cell and spatial transcriptomics, we found that the crosstalk between CAFs and cancer cells is crucial for the tumor-promoting effect of SDS. CAFs recruited by HCC via PDGFA may lead to ECM remodeling through activation of the TGF-β pathway, thereby forming a physical barrier to block immune cell infiltration under SDS. </p>
Dataset related to article "Hemodynamics in AVF over time: A protective role of vascular remodeling toward flow stabilization"
<p>Dataset containing magnetic resonance images, blood flow boundary conditions and post-processing of computational fluid simulations results</p>
Dataset related to the article: "BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice"
<p>Long-living individuals (LLIs) escape age-related cardiovascular complications until the very last stage of life. Previous studies have<br>shown that a Longevity-Associated Variant (LAV) of the BPI Fold Containing Family B Member 4 (BPIFB4) gene correlates with an<br>extraordinarily prolonged life span. Moreover, delivery of the LAV-BPIFB4 gene exerted therapeutic action in murine models of<br>atherosclerosis, limb ischemia, diabetic cardiomyopathy, and aging. We hypothesize that downregulation of BPIFB4 expression<br>marks the severity of coronary artery disease (CAD) in human subjects, and supplementation of the LAV-BPIFB4 protects the heart<br>from ischemia. In an elderly cohort with acute myocardial infarction (MI), patients with three-vessel CAD were characterized by<br>lower levels of the natural logarithm (Ln) of peripheral blood BPIFB4 (p = 0.0077). The inverse association between Ln BPIFB4 and<br>three-vessel CAD was confirmed by logistic regression adjusting for confounders (Odds Ratio = 0.81, p = 0.0054). Moreover, in<br>infarcted mice, a single administration of LAV-BPIFB4 rescued cardiac function and vascularization. In vitro studies showed that LAVBPIFB4<br>protein supplementation exerted chronotropic and inotropic actions on induced pluripotent stem cell (iPSC)-derived<br>cardiomyocytes. In addition, LAV-BPIFB4 inhibited the pro-fibrotic phenotype in human cardiac fibroblasts. These findings provide a<br>strong rationale and proof of concept evidence for treating CAD with the longevity BPIFB4 gene/protein.</p>
Electrophysiological recods (30 mg/kg) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"
<p>Electrophysiological recods (30 mg/kg) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"</p>
Behavioural videos (Control group) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"
<p>Behavioural videos (Control group) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"</p>
Electrophysiological recods (5 mg/kg) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"
<p>Electrophysiological recods (5 mg/kg) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"</p>
Behavioural videos (30 mg/kg group) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"
<p>Behavioural videos (30 mg/kg group) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"</p>
Behavioural videos (5 mg/kg group) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"
<p>Behavioural videos (5 mg/kg group) of the article: "Distinguishing Psychomimetic from Antidepressant-Like Effects in Mice using Molecular and Electrophysiological Biomarkers"</p>
Dataset related to article "Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models"
<p>The file contains the raw datasets related to the figures of the work (i.e. behavioural analysis, western blot, immunofluorescence, RT-qPCR). Each sub-folder of the Excel file refers to a specific figure.</p> <p>Full blot images are provided in the electronic version of the paper at the following link:</p> <p><a href="https://static-content.springer.com/esm/art%3A10.1186%2Fs41232-023-00270-w/MediaObjects/41232_2023_270_MOESM2_ESM.pdf" target="_blank" rel="nofollow noopener noreferrer">https://static-content.springer.com/esm/art%3A10.1186%2Fs41232-023-00270-w/MediaObjects/41232_2023_270_MOESM2_ESM.pdf</a></p>
Export Quality, Employment (Skill level and aggregate) and other variables dataset for research article titled - Dual Edge of Export Quality: Does it Boost Employment? Insights from OECD and G20 Countries
<p>The analysis has been carried out for a sample of 45 countries belonging to the G20 and OECD for the period–1990-2019. For skill level analysis, the data is available for 33 countries for low-, high-, and semi-skill employment and 22 countries for unskilled employment. For low- and high-skill employment, data is available for 1995-2019; for semi-skill employment, it is available for 2000-2019, and for unskilled employment for 2006-2019. The employment datasets are obtained from the International Labour Organization (ILO) website and export quality indicators from the International Monetary Fund (IMF) online database website. The datasets on R&D, FDI, Gross Fixed capital formation, Medium and high technology exports, ICT indicators, and export unit value index are obtained from the World Bank’s World Development Indicators (WDI) and average Tariff data from the World Integrated Trade Solution (WITS) website. </p>
Raw data for the article "Bi2Se3-MWCNT heterostructures as catalysts for CO2 photothermal reduction"
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Data set related to the article "An in vitro model for cardiac organoid production: the combined role of geometrical confinement and substrate stiffness"
<p>This record contains raw data related to the article "An in vitro model for cardiac organoid production: the combined role of geometrical confinement and substrate stiffness"</p>
Dataset related to article: "Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise"
<p>We provide the raw data used for the following article:</p> <p>Vitacca, M.; Paneroni, M.; Malovini, A.; Carlucci, A.; Binda, C.; Sanci, V.; Ambrosino, N. Clusters of Survivors of COVID-19 Associated Acute Respiratory Failure According to Response to Exercise. <em>Int. J. Environ. Res. Public Health</em> 2021, 18, 11868.</p> <p><strong>Abstract</strong>: COVID-19 survivors are associated with acute respiratory failure (ARF) and show a high prevalence of impairment in physical performance. The present studied aimed to assess whether we may cluster these individuals according to an exercise test. The presented study is a retrospective analysis of 154 survivors who were admitted to two hospitals of Istituti Clinici Scientifici Maugeri network, Italy. Clinical characteristics, walked distance, heart rate (HR), pulse oximetry (SpO2), dyspnoea, and leg fatigue (Borg scale: Borg-D and Borg-F, respectively) while performing the sixminute walking distance (6MWT) were entered into unsupervised clustering analysis. Multivariate linear regression identified variables that were informative for the set of variables used for cluster definition. Cluster 1 (C1: 86.4% of participants) and Cluster 2 (C2: 13.6%) were identified. Compared to C1, the individuals in C2 were significantly older, showed significantly higher increase in fatigue and in dyspnoea, greater reduction in SpO2, and a lower HRpeak during the test. The need of walking aids, time from admission to acute care hospitals, age, body mass index, endotracheal intubation, baseline HR and baseline Borg-D, and exercise-induced SpO2 change were significantly associated<br> with the variables that were used for cluster definition. Different characteristics and physiological parameters during the 6MWT characterise survivors of COVID-19-associated ARF. These results may help in the management of the long-term effects of the disease.</p>
Dataset related to article "Risk Stratification of Cholangiocarcinoma Patients Presenting with Jaundice: A Retrospective Analysis from a Tertiary Referral Center"
<p>Dataset related to article "Risk Stratification of Cholangiocarcinoma Patients Presenting with Jaundice: A Retrospective Analysis from a Tertiary Referral Center"</p> <p>Cholangiocarcinomas (CCAs) are a heterogeneous group of tumors that arise from the biliary tract. Jaundice is a common clinical presentation; however, the prognostic impact of this symptom is poorly understood, and current management recommendations lack solid evidence. We aim to assess the clinical outcomes and predictive factors of CCA patients presenting with jaundice in the Emergency Room (ER). We retrospectively analyzed all consecutive ER cases presenting with jaundice between January 2010 and December 2017. During the study period, 403,766 patients were admitted to the ER, 1217 (0.3%) presented with jaundice, and in 200 (0.049%), the diagnosis was CCA. CCA cases increased during the study period (<em>p</em> for trend 0.026). Most of them presented with advance disease (stage III 46.5%, stage IV 43.5%) and median survival was 4.5 months (95% CI 3.4-6.0). Factors associated with better survival were age, stage of disease, presence of jaundice at the moment of diagnosis, and lack of concomitant viral hepatitis. A nomogram was constructed that significantly predicts 1-month, 6-month, and 1-year survival after patients' admission. In conclusion, the majority of CCA patients presenting with jaundice to the ER have advanced disease and poor prognosis. Risk stratification of these patients can allow tailored management.</p>
Dataset related to the article: Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson's Disease: Triggers for Respiratory Rehabilitation?
<p>Dataset related to the article:</p> <p>Vitacca, M.; Olivares, A.; Comini, L.; Vezzadini, G.; Langella, A.; Luisa, A.; Petrolati, A.; Frigo, G.; Paneroni, M. Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson’s Disease: Triggers for Respiratory Rehabilitation? <em>Int. J. Environ. Res. Public Health</em> <strong>2021</strong>, <em>18</em>, 12298.</p> <p>Abstract: The role that oxygen desaturation plays in exercise tolerance and its rehabilitative implications<br> in patients with Parkinson’s disease (PD) are unclear. We aimed to test exercise tolerance and<br> oxygen saturation levels both during exercise and at night in PD patients to better define their rehabilitative<br> needs. In clinically stable PD patients, undergoing inpatient rehabilitation, and in “ON” phase,<br> we prospectively assessed clinical data, sleepiness, comorbidities, PD severity (Hoehn&Yahr, HY),<br> motor function (ADLs, UPDRSII and UPDRSIII, Barthel Index, Functional Independence Measure),<br> balance, spirometry, respiratory muscles (MIP/MEP), peak cough expiratory flow (PCEF), continuous<br> night oxygen monitoring, and meters at 6MWT. Of 55 patients analyzed (28 with moderate–severe PD,<br> HY 2.5), 37% and 23% showed moderate–severe impairment on UPDRSII and UPDRSIII, respectively;<br> 96% had reduced exercise tolerance and severe respiratory muscles impairment (MIP/MEP<br> < 45% pred.); 21.8% showed desaturations during exercise; and 12.7% showed nocturnal desaturations.<br> At multiple regression, low exercise tolerance and low mean nocturnal and exercise-induced<br> saturation correlated with several respiratory and motor function and disability indices (all p <<br> 0.03). Exercise tolerance, exercise-induced desaturations, and nocturnal desaturations were extremely<br> frequent in PD patients and were worse in more severe PD patients. This suggests considering a<br> combined role for motor and respiratory rehabilitation in these patients.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.