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15,738 results for “Stem cells”
Data from: Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
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Thy1-positive spermatogonia suppress the proliferation of spermatogonial stem cells by Extracellular vesicles in vitro
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Data from: Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration
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Data from: Intracoronary delivery of human mesenchymal/stromal stem cells: insights from coronary microcirculation invasive assessment in a swine model
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Data from: Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin—integration and visualization of multi-omics data
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Genomic profile of gene edited hematopoietic stem cells
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Data from: Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins
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The effect of intra-articular injection of secretome of umbilical cord mesenchymal stem cells in articular cartilage repair in sheep model
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Data from: Stem cell differentiation trajectories in Hydra resolved at single-cell resolution
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Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade
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Data from: Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures
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Global gene expression profiles of cardiac progenitors differentiated from human pluripotent stem cells in 3D culture under simulated microgravity
Efficient generation of cardiomyocytes from human pluripotent stem cells is critical for their regenerative applications. Microgravity and 3D culture can profoundly modulate cell proliferation and survival. Here we engineered microscale progenitor cardiac spheres from human pluripotent stem cells and exposed the spheres to simulated microgravity using a random positioning machine for 3 days during their differentiation to cardiomyocytes. Methods: RNA-seq libraries were prepared using the Illumina TruSeq RNA kit and the TrueSeq method was employed for mRNA enrichment. The libraries were quantified and samples were multiplexed in each lane of the flowcell. Cluster generation was performed and then sequenced on the Illumina HiSeq1000 system. Reads were mapped on the Human Genome Reference and normalized expression table was generated. Results: Among differentially expressed genes 53 of them were up-regulated and 75 were down-regulated. Conclusions: Data demonstrate increased expression of genes associated with growth development and pro-survival in cardiac progenitors cultured under simulated microgravity compared with those cultured under standard gravity. RNA-sequencing analysis was performed to compare global gene expression profiles of cells at differentiation day 8 under simulated microgravity vs. standard gravity.
Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
With extended stays aboard the International Space Station (ISS) becoming commonplace there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to study the effects of microgravity on cell-level cardiac function and gene expression. The hiPSC-CMs were cultured aboard the ISS for 5.5 weeks and their gene expression structure and functions were compared to ground control hiPSC-CMs. Exposure to microgravity on the ISS caused alterations in hiPSC-CM calcium handling. RNA-sequencing analysis demonstrated 2,635 genes were differentially expressed among flight post-flight and ground control samples including genes involved in mitochondrial metabolism. This study represents the first use of hiPSCs to model the effects of spaceflight on human cardiomyocyte structure and function.
MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction II.
GEO Series GSE150666. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by activating a shunt pathway that generates the toxic metabolite 24(S),25-epoxycholesterol
GEO Series GSE222971. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing on stem cell-derived endothelial cells
GEO Series GSE156009. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Prospective isolation and characterization of renal cancer stem cells from human Wilms' tumor xenografts leads to tumor eradication
GEO Series GSE33332. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Enrichment of pluripotent stem cell-derived hepatocyte-like cells
GEO Series GSE86453. Homo sapiens. 24 samples. Type: Expression profiling by array.
Trophoblast stem cell derivation from naive and primed hPSC enables ELF5 functional analysis (miRNAseq)
GEO Series GSE297156. Homo sapiens. 18 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [ATAC-Seq]
GEO Series GSE208066. Mus musculus. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.