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Dataset results
2,189 results for “AML”
Loss of the metabolic sensor, PPARA, overcomes differentiation blockade and immune suppression in AML
GEO Series GSE158938. Mus musculus. 6 samples. Type: Expression profiling by array.
Gata2 promotes drug resistance in Acute Myeloid Leukemia (AML) [ChIP-Seq]
GEO Series GSE264719. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Protein binding profiles on chromatin in human AML cells
GEO Series GSE158282. Homo sapiens. 46 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScRNA-Seq of Human MDS and AML Bone Marrow Marrow Microenvironment.
GEO Series GSE288862. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Leucegene: AML sequencing
GEO Series GSE67040. Homo sapiens. 452 samples. Type: Expression profiling by high throughput sequencing.
HDAC8i/NAMPTi combination on the transcriptomes of leukemia initiating cells of AML patients
GEO Series GSE161397. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Gene expression of MOLM14 (AML cell line) transfected with siATF4 or siCTRL
GEO Series GSE151130. Homo sapiens. 6 samples. Type: Expression profiling by array.
IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells [ChIP-seq]
GEO Series GSE174559. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
MLL partner genes confer distinct biological and clinical signatures of pediatric AML, an AIEOP study
We retrospectively analyzed AML patients enrolled in the AIEOP since 2000, 42 patients with 11q23 rearrangement were analyzed by gene expression profile. Gene expression analyses were performed to compare AML MLL partner genes (AF9, AF10, AF6, ENL, ELL, Septin 6, and AF1q).
Pediatric AML and Normal Bone Marrow
This series represents leukemic samples obtained from pediatric AML patients at diagnosis and control normal bone marrow samples.
Germline Genetics of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Myelodysplastic syndromes (MDS) are part of a heterogeneous and overlapping group of clonal diseases that arise in the hematopoietic stem or progenitor cells and also include acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and the hybrid MDS/MPN entities. Individuals with MDS have a high risk of progressing to leukemia, with approximately 30% expected to develop AML. This study evaluates genetic susceptibility to myeloid malignancy using data from population-based case control studies of myelodysplastic syndromes and acute myeloid leukemia in adults (ages 18-85 years) and pediatric MDS cases with banked samples at the Center for International Blood and Marrow Transplant Research (CIBMTR). Adult cases were identified through the Minnesota Cancer Reporting System and controls were recruited from the State Driver's License/Identification Card list. DNA samples were collected via mouthwash collection kits (AML cases and controls) or Oragene saliva collection kits (adult MDS cases and controls). Pediatric MDS samples were banked at CIBMTR prior to receipt of a transplant and DNA was extracted from isolated T cells or whole blood samples. Genotyping data were generated using the Illumina Global Diversity array and quality control and genotype calling was conducted using established best practices. Our primary analyses investigated the contribution of genetic variation to MDS risk and evaluated the role of the killer cell immunoglobulin receptors (KIR) on incidence and survival.
TARGET: Acute Myeloid Leukemia (AML)
There are 200+ fully characterized patient cases with AML (all tumor/normal pairs, 100 with relapse sample as well) that make up the TARGET AML dataset, each with gene expression, tumor and paired normal copy number analyses, methylation and comprehensive next-generation sequencing to include whole genome sequencing, mRNA-seq and miRNA-seq. A subset of these cases will also have whole exome sequencing data available as well. There are additionally a large number of cases with partial molecular characterization making this a large and informative genomic dataset. Additionally, the TARGET AML cohort includes some highly aggressive subtypes including AML "induction failures." Upon diagnosis, AML patients without high-risk genetic markers undergo standard chemotherapy, called the primary induction phase. This phase lasts about 30 days and is designed to eliminate cancer cells. Success of treatment is measured by the percentage of myeloblasts, i.e. immature white blood cells, detected in the patient following primary induction. Patients with greater than 15% myeloblasts did not sufficiently respond to standard therapy and are "induction failures." Currently, these patients have very poor prognoses and few clinical options. There are 30 patient cases that make up the TARGET AML Induction failure dataset, each with a primary tumor sample, a "normal" fibroblast sample grown from the patient's bone marrow, and a sample obtained at the end of induction. The trios for each case are characterized with next generation sequencing platforms to include whole genome, miRNA-Seq and mRNA-Seq. Gene expression and copy number analyses were also determined from mRNA-seq and whole genome sequencing respectively.
Ring1A and Ring1B maintain murine MOZ-TIF2 AML stem cells by inhibiting expression of Glis2
GEO Series GSE93214. Mus musculus. 12 samples. Type: Expression profiling by array.
CD34 negative populations are associated with an increased relapse risk in childhood AML and harbor chemo-resistant leukemia stem cells
GEO Series GSE45249. Homo sapiens. 27 samples. Type: Expression profiling by array.
Expression array of DNMT1 inhibitor treated 3 AML cell lines
GEO Series GSE134742. Homo sapiens. 16 samples. Type: Expression profiling by array.
Treatment of human AML cell lines MOLM-14 and THP-1 with MUC1 specific shRNA
GEO Series GSE99510. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Gene expression analysis of DAC treated AML: high impact or tumor suppressor gene expression changes
GEO Series GSE84334. Homo sapiens. 45 samples. Type: Expression profiling by array.
Shawlab Analysis of Tanja Gruber's AML Cell lines
<p>GruberLabAMLCellLineApp Folder was obtained from the Networkbiology server.</p> <p> </p> <p> </p>
CRISPR Phenotypic enrichment screen for epigenetic regulators of MEIS1 expression in acute myeloid leukemia (AML) [CRISPRScreens]
GEO Series GSE217778. Homo sapiens. 6 samples. Type: Other.
RNA-seq in murine acute myeloid leukemia (AML) cells with and without knockdown of Tet1
GEO Series GSE116548. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.