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423
datasets available to search
ShareScore release 0.9.0
Dataset results
423 results for “Brain aging”
Spatial Transcriptomics Uncovers Brain Region-Specific Transcriptional Changes Associated with Development and Aging
GEO Series GSE287202. Mus musculus. 6 samples. Type: Other.
Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets
GEO Series GSE218637. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq to determine PRC2 targets in the aging Drosophila brain.
GEO Series GSE110135. Drosophila melanogaster. 19 samples. Type: Expression profiling by high throughput sequencing.
Single-cell m6A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation [aged study]
GEO Series GSE268159. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Regional Differences in gene expression and promoter usage in aged human brains
GEO Series GSE43472. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing.
Data from: Association of CD14 with incident dementia and markers of brain aging and injury
Objective To test the hypothesis that the inflammatory marker plasma soluble CD14 (sCD14), associates with incident dementia and related endophenotypes in two community-based cohorts. Methods. Our samples included the prospective community-based Framingham Heart Study (FHS) and Cardiovascular Health Study (CHS) cohorts. Plasma sCD14 was measured at baseline and related to the incidence of dementia, domains of cognitive function, and MRI defined brain volumes. Follow-up for dementia occurred over a mean of 10 years (SD, 4) in the FHS and a mean of 6 years (SD, 3) in the CHS. Results We studied 1588 participants from the FHS (mean age 69±6 years, 47% male,131 incident events) and 3129 participants from the CHS (mean age 72±5 years, 41% male, 724 incident events) for the risk of incident dementia. Meta-analysis across the two cohorts showed that each standard deviation unit increase in sCD14 was associated with a 12% increase in the risk of incident dementia (95% confidence interval [CI], 1.03 to 1.23; P=0.01) following adjustments for age, sex, APOE ε4 status, and vascular risk factors. Higher levels of sCD14 were associated with various cognitive and MRI markers of accelerated brain aging in both cohorts and with a greater progression of brain atrophy and a decline in executive function in the FHS. Conclusion. sCD14 is an inflammatory marker related to brain atrophy, cognitive decline, and incident dementia.
Data from: Integrated analysis and visualization of group differences in structural and functional brain connectivity: applications in typical ageing and schizophrenia
Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple metrics are presented. On the global level, "bi-modal comparison plots" show the distribution of uni- and bi-modal group differences and the relationship between structure and function. Differences between brain lobes are visualized using "worm plots". Group differences in connections are examined with an existing visualization, the "connectogram". These visualizations were evaluated in two proof-of-concept studies: (1) middle-aged versus elderly subjects; and (2) patients with schizophrenia versus controls. Each included two measures derived from diffusion weighted images and two from functional magnetic resonance images. The structural measures were minimum cost path between two anatomical regions according to the "Statistical Analysis of Minimum cost path based Structural Connectivity" method and the average fractional anisotropy along the fiber. The functional measures were Pearson's correlation and partial correlation of mean regional time series. The relationship between structure and function was similar in both studies. Uni-modal group differences varied greatly between connectivity types. Group differences were identified in both studies globally, within brain lobes and between regions. In the aging study, minimum cost path was highly effective in identifying group differences on all levels; fractional anisotropy and mean correlation showed smaller differences on the brain lobe and regional levels. In the schizophrenia study, minimum cost path and fractional anisotropy showed differences on the global level and within brain lobes; mean correlation showed small differences on the lobe level. Only fractional anisotropy and mean correlation showed regional differences. The presented visualizations were helpful in comparing and evaluating connectivity measures on multiple levels in both studies.
Dairy Intake and Brain Health in Aging
ClinicalTrials.gov study NCT02245035. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging
ClinicalTrials.gov study NCT06123182. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
ClinicalTrials.gov study NCT03954899. IPD Sharing: NO. Countries: 1. Publications: 0.
Aging Brain Changes, Executive Dysfunction and Depression
ClinicalTrials.gov study NCT00918684. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Health and Aging Brain Study: Health Disparities Tau Positron Emission Tomography (PET) Scan Study
ClinicalTrials.gov study NCT05076331. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17
ClinicalTrials.gov study NCT01696292. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Descriptive Study of Brain Velocity in Transcranial Doppler in Newborns Over 35 Weeks of Gestational Age in the Maternity Ward
ClinicalTrials.gov study NCT03553134. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Database of Positon Emission Tomography (PET) Digital Brain Exams, in 50th Age of Patients
ClinicalTrials.gov study NCT04163276. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing
ClinicalTrials.gov study NCT05675007. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Blueberry Intervention Study for Brain Aging
ClinicalTrials.gov study NCT05024916. IPD Sharing: NO. Countries: 1. Publications: 0.
AT-001 for Long-term Preservation of Brain Health in Aging
ClinicalTrials.gov study NCT03062384. IPD Sharing: NO. Countries: 1. Publications: 0.
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease
ClinicalTrials.gov study NCT02137460. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Age, Traumatic Brain Injury and Injury Severity as Independent Risk Factors for In-Hospital Mortality in Polytrauma Patients.
ClinicalTrials.gov study NCT04335838. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.