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225
datasets available to search
ShareScore release 0.9.0
Dataset results
225 results for “Dilated Cardiomyopathy”
RNA-Binding Protein RBM20 Upregulation Enhances Dilated Cardiomyopathy by Alternative Splicing of Atp6v0a1
GEO Series GSE281344. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression signature of cardiac muscle as a potential diagnostic or prognostic tool for dilated cardiomyopathy
GEO Series GSE9800. Homo sapiens. 30 samples. Type: Expression profiling by array.
Effect of TPTN on gene expression in doxorubicin-induced dilated cardiomyopathy
GEO Series GSE220177. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Dysregulation of PDGFRB contributes to the pathogenesis of LMNA-related dilated cardiomyopathy
GEO Series GSE101514. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Changes in molecular profiles of the left ventricle during progressive dilated cardiomyopathy linked heart failure
GEO Series GSE225008. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Whole human genome expression analysis on left ventricular free wall heart tissue samples (Dilated Cardiomyopathy)
GEO Series GSE111544. Homo sapiens. 14 samples. Type: Expression profiling by array.
Abnormal circadian rhythms exacerbate dilated cardiomyopathy by reducing the ventricular mechanical strength
GEO Series GSE270258. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Myocardial-specific ablation of Jarid2 leads to dilated cardiomyopathy in mice
GEO Series GSE118945. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cytotoxic T-cells drive out come in Inflammatory Dilated Cardiomyopathy
GEO Series GSE278521. Homo sapiens. 37 samples. Type: Expression profiling by high throughput sequencing.
Impaired reorganization of centrosome structure underlies human congenital dilated cardiomyopathy
GEO Series GSE184899. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
LncRNA DCRT protects against dilated cardiomyopathy via binding to PTBP1 (RIP-seq)
GEO Series GSE243739. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Human iPSC-derived cardiomyocyte from a patient with dilated phase of hypertrophic cardiomyopathy
GEO Series GSE263980. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
NEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes
GEO Series GSE282940. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
LncRNA DCRT protects against dilated cardiomyopathy via binding to PTBP1
GEO Series GSE243740. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Role of CDCP1 and Cardiac Fibrosis in a Mouse Model of Dilated Cardiomyopathy (DCM)
GEO Series GSE303631. Mus musculus. 4 samples. Type: Other.
The dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons [Ribo-TRAP RNA-seq]
GEO Series GSE250096. Mus musculus. 18 samples. Type: Other.
Overexpression of dn-p21ras as a model system for severe dilated cardiomyopathy
GEO Series GSE760. Mus musculus. 6 samples. Type: Expression profiling by array.
The dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons
GEO Series GSE250100. Mus musculus. 28 samples. Type: Other.
Dataset related to article "Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities"
<p>This record contains raw data related to article "Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities"</p><p>Abstract</p><p>Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line. PALLD is ubiquitously expressed in several isoforms, and its longest 200 kDa isoform, predominantly expressed in striated muscle, shows high structural homology to MYPN. <i>MYPN</i> gene mutations are associated with human cardiomyopathies, whereas the role of PALLD in the heart has remained unknown, partly due to embryonic lethality of PALLD knockout mice. In a yeast two-hybrid screening, CARP/Ankrd1 and FHOD1 were identified as novel interaction partners of PALLD's N-terminal region. To study the role of PALLD in the heart, we generated conditional (cPKO) and inducible (cPKOi) cardiomyocyte-specific PALLD knockout mice. While cPKO mice exhibited no pathological phenotype, ablation of PALLD in adult cPKOi mice caused progressive cardiac dilation and systolic dysfunction, associated with reduced cardiomyocyte contractility, intercalated disc abnormalities, and fibrosis, demonstrating that PALLD is essential for normal cardiac function. Double cPKO and MYPN knockout (MKO) mice exhibited a similar phenotype as MKO mice, suggesting that MYPN does not compensate for the loss of PALLD in cPKO mice. Altered transcript levels of <i>MYPN</i> and <i>PALLD</i> isoforms were found in myocardial tissue from human dilated and ischemic cardiomyopathy patients, whereas their protein expression levels were unaltered.</p>
Dataset related to the article "CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry"
<p>This record contains raw data related to the article “CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry” <br> </p> <p>Abstract</p> <p><strong>Aims: </strong>The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.</p> <p><strong>Methods and results: </strong>In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT<a href="http://clinicaltrials.gov/show/NCT03352648">#NCT03352648</a>), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction <50% were included. All-cause mortality and major adverse arrhythmic cardiac events (MAACE) were the primary and secondary endpoints, respectively. During a median follow-up of 959 days, all-cause mortality and MAACE occurred in 72 (7%) and 93 (9%) patients, respectively. Age and >3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort.</p> <p><strong>Conclusion: </strong>In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.