Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
233
datasets available to search
ShareScore release 0.9.0
Dataset results
233 results for “Long-read”
An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing
<p>Relavant codes and notebooks for data analysis: <a href="https://github.com/lzx325/CRC-atlas">https://github.com/lzx325/CRC-atlas</a></p>
Accurate isoform quantification by joint short- and long-read RNA-sequencing
GEO Series GSE271530. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells
GEO Series GSE269496. Mus musculus; Homo sapiens. 27 samples. Type: Other.
Long-read sequencing for the assessment of therapeutic CRISPR/Cas9 strategy for the removal of aberrant DM1-causing CTG repeats in DMPK gene locus
GEO Series GSE279054. Homo sapiens. 5 samples. Type: Other.
Long-read sequencing reveals increased occurrence of genomic variants and adenosine methylation in Bacillus pumilus SAFR-032 after long-duration flight exposure onboard the International Space Station
Bacillus pumilus SAFR-032, an endospore-forming bacterial strain, was investigated to determine its methylation pattern (methylome) change, compared to ground control, after direct exposure to space conditions onboard the International Space Station (ISS) for 1.5 years. The resulting ISS-flown and non-flown strains were sequenced using the Nanopore MinION and an in-house method and pipeline to identify methylated positions in the genome. Our analysis indicated genomic variants and m6A methylation increased in the ISS-flown SAFR-032. To complement the broader omics investigation and explore phenotypic changes, ISS-flown and non-flown strains were compared in a series of laboratory-based chamber experiments using an X-ray irradiation source (doses applied at 250, 500, 750, 1000 and 1250 Gy); results show a potentially higher survival fraction of ISS-flown DS2 at the two highest exposures. Taken together, results from this study document lasting changes to the genome by methylation, potentially triggered by conditions in spaceflight, with functional consequences for the resistance of bacteria to stressors expected on long-duration missions beyond low Earth orbit.
Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight
The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic lines of Arabidopsis thaliana, wild-type Col-0 and the mutant elp2-5, which is deficient in an epigenetic regulator Elongator Complex Subunit 2 (ELP2). Whole-genome bisulfite sequencing (WGBS) revealed distinct spaceflight associated methylation differences, presenting the need to explore specific space-altered methylation at single-molecule resolution to associate specific changes over large regions of spaceflight related genes. To date, tools of multiplexed targeted DNA methylation sequencing remain limited for plant genomes. This data set includes single-molecule profiling in user-defined targets using Flap-Enabled Next-Generation Capture (FENGC) on Arabidopsis root tissues to reveal precise modification of DNA methylation regulated by Elongator Complex Subunit 2 during spaceflight.
Long-read RNA sequencing reveals synaptic genes with differential isoform usage in schizophrenia [long-read RNAseq ]
GEO Series GSE282551. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Nanopore long-read transcriptomics profiling reveals gene expression signatures of mouse tumor endothelial cells 2H-11
GEO Series GSE191094. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Long-read RNA sequencing reveals synaptic genes with differential isoform usage in schizophrenia [short-read RNAseq ]
GEO Series GSE282552. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Long-Read Single-Cell Sequencing Confirms the Synaptic Disruptions and Developmental Delays in Neurabin I+/- iNeurons: Molecular Rescue via Gene-based Approaches
GEO Series GSE283629. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Long-Read Sequencing and Proteomics Reveal Blood Transcriptome and Protein Expression Profiles in Multiple Primary Lung Cancers
GEO Series GSE311391. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A Self-Complementary AAV Proviral Plasmid System to Reduce Aberrant Cross-Packaging and ITR Promoter Activity in AAV Vector Preparations (Long-read)
GEO Series GSE272650. synthetic construct. 2 samples. Type: Other.
A technology-agnostic long-read analysis pipeline for transcriptome discovery and quantification
GEO Series GSE147118. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read and single-molecule resolution [Nanopore]
GEO Series GSE290978. Homo sapiens. 18 samples. Type: Other.
Long-read single-cell RNA sequencing analysis of key genes and isoforms during corneal wound healing in Macaca fascicularis
GEO Series GSE278797. Macaca fascicularis. 6 samples. Type: Expression profiling by high throughput sequencing.
Integrated long-read transcriptomic profiling of peripheral blood from ankylosing spondylitis patients reveals regulatory shifts and core genes associated with programmed cell death
GEO Series GSE299639. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read and single-molecule resolution
GEO Series GSE291013. Homo sapiens. 34 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Oxford Nanopore Technology (ONT) long-read data of NCIH2170 cell line
GEO Series GSE293274. Homo sapiens. 2 samples. Type: Other.
Comprehensive long-read transcriptome analysis uncovers alternative RNA processing feature and isoform diversity in ovarian cancer progression
GEO Series GSE315136. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
A technology-agnostic long-read analysis pipeline for transcriptome discovery and quantification
GEO Series GSE132766. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.