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943 results for “Pancreas”
Data from: Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas
Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine, ductal, and acinar cells but become bipotent by embryonic day 13.5, giving rise to endocrine cells and ductal cells. However, the dynamics of individual progenitors balancing self-renewal and lineage-specific differentiation has never been described. Using three-dimensional live imaging and in vivo clonal analysis, we reveal the contribution of individual cells to the global behaviour and demonstrate three modes of progenitor divisions: symmetric renewing, symmetric endocrinogenic, and asymmetric generating a progenitor and an endocrine progenitor. Quantitative analysis shows that the endocrine differentiation process is consistent with a simple model of cell cycle–dependent stochastic priming of progenitors to endocrine fate. The findings provide insights to define control parameters to optimize the generation of β-cells in vitro.
Figures 11-14 from: Vaissi S, Parto P, Sharifi M (2017) Anatomical and histological study of the liver and pancreas of two closely related mountain newts Neurergus microspilotus and N. kaiseri (Amphibia: Caudata: Salamandridae). Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e13229
Figures 11-14 - Pancreas of N. kaiseri. (11) Pancreas is a triangular organ and it's situated in the curvature of duodenum. (12) Its composed of numerous masses of exocrine acini (black arrow) which secret digestion enzyme. Langerhounse Island (white arrow) is also present (H&E, ×1000). (13) Acini (arrow) is enzyme secreting units of exocrine portion of pancreas. Each acinius is an ovoid elliptical cluster of pyramid-shaped secretory cells surrounding the lumen. In the apical portion of the cells these are aggregated bright eosinophilic zymogens granules. The round or flattened cell nuclei are located basally (H&E, ×4000). (14) Pancreatic acini drain into a branched system of variously sized ducts. In this Image the duct (arrow) is surrounded by a simple cuboidal epithelium (H&E, ×2500).
Figures 9-10 from: Vaissi S, Parto P, Sharifi M (2017) Anatomical and histological study of the liver and pancreas of two closely related mountain newts Neurergus microspilotus and N. kaiseri (Amphibia: Caudata: Salamandridae). Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e13229
Figures 9-10 - (9) Gall bladder of N. microspilotus (H&E, ×300). (10) Gall bladder wall consists of a simple columnar epithelium (arrow) supported by underlying fibrovascular lamina propria submucosa (LPS) (H&E, ×2500). The epithelial cells are very tall and possess elongated nuclei basally located. These lining cells consecrate bile. (GB) Gall bladder, (P) Pancreas, (TM) Tunica muscularis.
Figures 1-4 from: Vaissi S, Parto P, Sharifi M (2017) Anatomical and histological study of the liver and pancreas of two closely related mountain newts Neurergus microspilotus and N. kaiseri (Amphibia: Caudata: Salamandridae). Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e13229
Figures 1-4 - The liver of N. microspilotus (1, 2) and N. kaiseri (3, 4). (1, 3) Dorsal surface; (2–4) ventral surface. (R) Right, (L) left, (AL) accessory lobe, (GB) gall bladder.
Figures 5-8 from: Vaissi S, Parto P, Sharifi M (2017) Anatomical and histological study of the liver and pancreas of two closely related mountain newts Neurergus microspilotus and N. kaiseri (Amphibia: Caudata: Salamandridae). Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e13229
Figures 5-8 - Liver of N. microspilotus. (5) The liver tissue demonstrates the sponge-like appearance of the parenchyma, which is composed of polyhedral hepatocyts. Numerous dark brown spots are small melanomacrophage centers (H&E, ×1000). (6) Cords of hepatocyte separated by sinusoids (arrows) containing erythrocyte. Hepatocytes are large cells with central nuclei (H&E, ×4000). (7) Central vein (*) and intrahepatic ducts (arrow) are seen in this picture (H&E, ×2500). (8) Liver parenchyma (PAS, ×1000). One of the liver's most metabolic functions is storage of glycogen. At this high magnification, one can see that the hepatocytes are strongly stained in magenta by the PAS method; this reaction reveals the presence of red granules including glycogen.
Organ Mapping Antibody Panel (OMAP) for Multiplexed Antibody-Based Imaging of Human Pancreas with CODEX
<p>Representative dataset using OMAP-13: Organ Mapping Antibody Panel (OMAP) for Multiplexed Antibody-Based Imaging of Human Pancreas with CODEX, v1.0. See https://humanatlas.io/omap.</p>
Small Toy Pancreas TPM Expression Dataset
<p>Small TPM expression of genes in the pancreas. Original data is from GTEX v8 on TPM counts of genes in the pancreas</p>
PhII Study STA-9090 as Second or Third-Line Therapy for Metastatic Pancreas Cancer
ClinicalTrials.gov study NCT01227018. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Synthetic Human Secretin (ChiRhoStim®) Administered Intravenously to Stimulate Exocrine Pancreas Fluid Secretion for Collection Via Endoscope and Laboratory Analysis of DNA Markers
ClinicalTrials.gov study NCT01087801. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer
ClinicalTrials.gov study NCT05634720. IPD Sharing: YES. Countries: 1. Publications: 0.
Feasibility Trial Testing the Bionic Pancreas With ZP4207
ClinicalTrials.gov study NCT02971228. IPD Sharing: NO. Countries: 1. Publications: 0.
Lenalidomide With Gemcitabine in Treatment of Untreated Advanced Carcinoma of the Pancreas
ClinicalTrials.gov study NCT00837031. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection
ClinicalTrials.gov study NCT03434678. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Pemetrexed for Second-Line Pancreas Cancer
ClinicalTrials.gov study NCT00864513. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ganitumab in Locally Advanced Unresectable Adenocarcinoma of the Pancreas
ClinicalTrials.gov study NCT01318642. IPD Sharing: Not stated. Countries: 13. Publications: 0.
Immune Checkpoint Inhibitor M7824 and the Immunocytokine M9241 in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Advanced Pancreas Cancer
ClinicalTrials.gov study NCT04327986. IPD Sharing: YES. Countries: 1. Publications: 0.
The Set-Point Study: Evaluating Effects of Changing Glucose Target on Bionic Pancreas Performance
ClinicalTrials.gov study NCT02509065. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in High-Risk Hematology Group
ClinicalTrials.gov study NCT03141398. IPD Sharing: UNDECIDED. Countries: 0. Publications: 14.
The Insulin-Only Bionic Pancreas Bridging Study
ClinicalTrials.gov study NCT03565666. IPD Sharing: YES. Countries: 1. Publications: 0.
Gemcitabine/Cisplatin for Resected Pancreas Cancer: Establishing the Role of ERCC1 in Treatment Decision
ClinicalTrials.gov study NCT01188109. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.