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10,244 results for “Vaccine”
COVID-19 Vaccine Hesitancy in the Pandemic's Third Year
<p>Dataset and code for June 2022 study, "<strong>COVID-19 Vaccine Hesitancy in the Pandemic's Third Year"</strong></p>
A content analysis of Vietnam online news about a pentavaent vaccine in the EPI
<p>This includes two files:</p> <p>-One dataset includes details about the online newspaper articles about Quinvaxem, a 5-in-1 vaccine used in Expanded Programme on Immunization in Vietnam. It includes the names of articles, publication dates and original webpages which the author retrieved the articles from. </p> <p>- The coding framework used for categorizing articles. This was built based on codebooks used in previous studies about vaccine media analysis. It was piloted and tested for interrater reliability. </p>
The MOPEVAC multivalent vaccine induces sterile protection against New World Arenaviruses in non-human primates
<p>Pathogenic New World arenaviruses (NWAs) cause hemorrhagic fevers and can have high mortality rates, as shown in recent outbreaks in South America. Neutralizing antibodies (Nabs) are critical for protection from NWAs. Having shown that the MOPEVAC vaccine, based on a hyper-attenuated arenavirus, induces NAbs against Lassa fever, we hypothesized that expression of NWA glycoproteins in this platform might protect against NWAs. Cynomolgus monkeys immunized with MOPEVACMAC, targeting Machupo virus, prevented the lethality of this virus and induced partially NWA-cross-reactive Nabs. We then developed the pentavalent MOPEVACNEW vaccine, expressing glycoproteins from all pathogenic South American NWAs. Immunization of cynomolgus monkeys with MOPEVACNEW induced Nabs against five NWAs, strong innate followed by adaptive immune responses as detected by transcriptomics, and provided sterile protection against Machupo virus and the genetically distant Guanarito virus. MOPEVACNEW may thus be efficient to protect against existing and, potentially, emerging NWAs. </p>
Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study
<p>Both genetic and non-genetic factors contribute to individual variation in the immune response to vaccination. Understanding how genetic background influences variation in both the magnitude and persistence of vaccine-induced immunity is vital for improving vaccine development and identifying possible causes of vaccine failure. Dogs provide a relevant biomedical model for investigating mammalian vaccine genetics; canine breed structure and long linkage disequilibrium simplify genetic studies in this species compared to humans. The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a standard vaccination schedule with an attenuated combination vaccine containing antigens for canine adenovirus type 2, canine distemper virus, canine parainfluenza virus, canine parvovirus, and four strains of <em>Leptospira</em> bacteria. Serum antibody measurements for each viral and bacterial component were measured at multiple time points. Heritability estimations and GWAS were conducted using SNP genotypes at 279,902 markers together with serum antibody titer phenotypes. The heritability estimates were: (1) to <em>Leptospira</em> antigens, ranging from 0.178 to 0.628; and (2) to viral antigens, ranging from 0.199 to 0.588. There was not a significant difference between the overall heritability of vaccine-induced immune response to <em>Leptospira</em> antigens compared to viral antigens. Genetic architecture indicates that SNPs of low to high effect contribute to immune response to vaccination. GWAS identified two genetic markers associated with vaccine-induced immune response phenotypes. Collectively, these findings indicate that genetic regulation of the immune response to vaccination is antigen-specific and influenced by multiple genes of small effect.</p>
Mass Cytometry (CyTOF) FCS files from Priest et al. 2024. Human PBMC from longitudinal analysis of COVID-19, Bacterial Sepsis, mRNA vaccination cohorts.
<p>Mass Cytometry (CyTOF) FCS files from Priest et al. "Non-classical CD45RB<sup>lo</sup> memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection." Research Square 2024. </p> <p>Files are already normalised, debarcoded, gated, batch corrected and compensated as described in Priest et al. </p> <p>Data is from Human PBMCs of londitudanal cohorts of Severe COVID-19, Sepsis and mRNA vaccine recipients. </p> <p>Samples were barcoded, mixed and then split magnetically before staining with seperate antibody panels for CD3+ (CD4, Treg, Tfh, CD8, gdT) or CD3- (B cells, DC, NK, Monocytes) to give approximatly 1280 FCS files from 218 individuals. </p> <p>A follow up experiment with a B-cell specific panel and Tetramers is included. </p> <p>Patient level metadata and antibody panel details are included. </p> <p> </p>
Contextualization of enablers and barriers for COVID-19 vaccine uptake among adult tuberculosis patients attending selected clinics in Nairobi County, Kenya
<p>Although vaccination is a cost-effective, equitable, and impactful public health intervention in curbing the spread of infectious disease, low uptake is a significant concern, especially among high-risk population groups. Nearly half of the population is unvaccinated in Nairobi, yet there is a shortage of vaccination information on vulnerable tuberculosis (TB) patients. The interplay of factors influences uptake, and protecting this vulnerable group and the general population from severe disease, hospitalization, and deaths is worthy. The purpose of this study is to determine the prevalence and individual-level enablers and barriers to COVID-19 vaccine uptake among adult TB patients attending selected clinics in Nairobi County, Kenya. This cross-sectional mixed-method study was conducted at TB clinics across six sub-counties in Nairobi County. It included 388 participants sampled from each clinic's TB register. Quantitative data was collected using a questionnaire, and qualitative data was collected through key informant interviews and focus group discussions. Quantitative data was analyzed using descriptive statistics (frequencies and percentages for categorical variables and mean standard deviation for continuous variables) and inferential statistics (logistic regression). Qualitative data was analyzed through deductive coding and thematic analysis. The prevalence of COVID-19 vaccination was 46.1%, with 38.1% receiving complete vaccination. Mistrust in vaccine management (adjusted odds ratio (aOR)= 0.075, 95% confidence interval (CI): 0.025-0.229, <em>p </em><0.001) was a significant barrier to COVID-19 vaccine uptake. Perceived covid-19 susceptibility (aOR = 2.901, 95% CI: 1.258-6.688, <em>p </em>= 0.012) and perceived covid-19 seriousness (aOR = 3.294, 95% CI: 1.130-9.604, <em>p </em>= 0.029) were significant enablers of COVID-19 vaccine uptake. Qualitative themes related to individual-level barriers and enablers of COVID-19 vaccine uptake were fear of side effects, stigma, myths, and mistrust in the messaging for barriers and desire to protect others and risk perception as enablers. The study revealed critical individual-level factors related to COVID-19 vaccine uptake.</p>
Identifying one-to-one communication themes on HPV and HPV vaccination
<p>The aim of this study is to examine the factors that impact communication between doctors, young adolescents, parents, and caregivers when discussing HPV vaccination recommendations. We are interested in understanding how different topics are discussed based on patient characteristics. Specifically, we would like to explore the influence of factors such as religion, country of origin, educational level, and gender.</p> <p>Survey was carried out in the framework of the European project PROTECT-EUROPE (EU4H-1, Project ID 101080046). PROTECT-EUROPE is an EU4Health Project that champions gender-neutral vaccination programme in EU Member States to provide protection for everyone against cancers caused by HPV e.g. cervical, anal, penile, vaginal, vulval and oropharyngeal.</p>
Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and Eimeria tenella challenge
<p>A multi-omics study integrating gut microbiota and host metabolome to investigate the gastrointestinal health markers in broiler chickens (Cobb500) from an anti-coccidiosis vaccine trial.</p>
Data from: Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial
<p>Morbidity and mortality attributable to COVID-19 is devastating global health systems and economies. Bacillus Calmette Guérin (BCG) vaccination has been in use for many decades to prevent severe forms of tuberculosis in children. Studies have also shown a combination of improved long-term innate or trained immunity (through epigenetic reprogramming of myeloid cells) and adaptive responses after BCG vaccination, which leads to non-specific protective effects in adults. Observational studies have shown that countries with routine BCG vaccination programs have significantly less reported cases and deaths of COVID-19, but such studies are prone to significant bias and need confirmation. To date, in the absence of direct evidence, WHO does not recommend BCG for the prevention of COVID-19. This project aims to investigate in a timely manner whether and why BCG-revaccination can reduce infection rate and/or disease severity in health care workers during the SARS-CoV-2 outbreak in South Africa. </p> <p>These objectives will be achieved with a blinded, randomised controlled trial of BCG revaccination versus placebo in exposed front-line staff in hospitals in Cape Town. Observations will include the rate of infection with COVID-19 as well as the occurrence of mild, moderate or severe ambulatory respiratory tract infections, hospitalisation, need for oxygen, mechanical ventilation or death. HIV-positive individuals will be excluded. Safety of the vaccines will be monitored. A secondary endpoint is the occurrence of latent or active tuberculosis. Initial sample size and follow-up duration is at least 500 workers and 52 weeks. Statistical analysis will be model-based and ongoing in real time with frequent interim analyses and optional increases of both sample size or observation time, based on the unforeseeable trajectory of the South African COVID-19 epidemic, available funds and recommendations of an independent data and safety monitoring board. The study will be supported by a novel 3D lung organoid model of SARS-CoV-2 infection system that can mimic the cascade of immunological events after SARS-CoV-2 infection to determine and analyse the contribution of cellular components to the impact of BCG revaccination in this study.</p> <p>Given the immediate threat of the SARS-CoV-2 epidemic the trial has been designed as a pragmatic study with highly feasible endpoints that can be continuously measured. This allows for the most rapid identification of a beneficial outcome that would lead to immediate dissemination of the results, vaccination of the control group and outreach to the health authorities to consider BCG vaccination for all qualifying health care workers.</p>
Month-to-month proportion of LSD-vaccinated animals at regional level (NUTS3) in south-eastern Europe since January 2016 until November 2017 and reported LSD outbreaks
<p>The European Food Safety Authority (EFSA), under request of the European Commission, performed an epidemiological analysis of the lumpy skin disease (LSD) epidemics based on the data collected from the affected and at-risk Member States and non-EU countries in south-eastern Europe. The video at the link below shows the month-to-month proportion of LSD-vaccinated animals at regional level (NUTS3) since January 2016 until November 2017 and reported LSD outbreaks per month (red dots are the new outbreaks each month, grey dots are past outbreaks).</p> <p> </p> <p>*This designation is without prejudice to positions on status and is in line with UNSCR 1244 and the ICJ Opinion on the Kosovo Declaration of Independence.</p>
Supplemental Tables Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines
<p>Supplemental tables for paper titled "Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines"</p>
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
<p>Online Supplementary Dataset of the manuscript "Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines"</p>
Outgrowth of tumors expressing libraries of PresentER minigenes in vaccinated or unvaccinated immunocompetent mice
<p>Minigene sequencing of RMA/S tumors expressing libraries of PresentER peptide antigen minigenes after 17 days of growth in immunocompetent mice that were either vaccinated or nonvaccinated. "Pool 13" are wild type peptide minigenes. "Pool 18" are mutant peptide minigenes.</p>
LSD outbreaks and vaccination in South Eastern Europe
<p>In this map the dots represent the outbreaks of lumpy skin disease, a cattle disease with large economic impact, that in 2012 was spreading in Middle East, affecting Israel, and Lebanon. In 2013 lumpy skin disease expanded to Jordan, Egypt, Iraq and Turkey, where in 2014 it spread all over the country. In 2015 lumpy skin disease reached the western part of Turkey and in summer 2015 it entered Eastern Greece. After the winter 2015-2016 the disease reappeared in Spring 2016 and spread over the Balkan region, into Bulgaria, North Macedonia, Albania, Kosovo, Serbia and Montenegro. After the disease entered Greece, a regional vaccination campaign based on LSD homologous strain vaccine started in the Balkan region. In this map the different shades of blue represent the percentage of animals vaccinated. By the end of 2017 the number of outbreaks had fallen by 95% and remain concentrated in area with the lowest vaccination coverage. However, the disease had not been eliminated therefore the vaccination program continued. In 2018 no outbreaks have been reported in the Balkan region, showing the high effectiveness of the coordinated regional vaccination campaign. On the other side outbreaks were still reported in Turkey, especially in the eastern part of the country, in Georgia and in Russia, where the disease is moving northwards and eastwards.</p>
Source ELISA data for the manuscript "Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice"
<p>This repository contains the source ELISA data for the manuscript "Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice" currently under review by PLOS ONE.</p> <p>It supports the following figures:</p> <p>Fig 4A: rHA ELISA data miniHA study.xlsx<br> Fig 4B: Competition ELISA data miniHA study.xlsx<br> S7 Fig: Competition ELISA data POC study.xlsx</p> <p> </p> <p>Files include Raw OD's per plate and reported values analysis. </p> <p> </p>
Google search trends for different vaccines from 1st June 2014 to 31st May 2019
<p>This is "Additional file" for the manuscript "Global search trends on common vaccine-related information in English on the internet"</p>
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.
<p>Here you will find the raw data (RawData.RData) and code (CHIVAS_SEROLOGY_Code.Rmd, an R Markdown file) for generating the analysis and figures for the following publication:</p> <p><strong><em>Streptococcus pyogenes</em> pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.</strong></p> <p>Joshua Osowicki1,2,3 #, Hannah R Frost1 #, Kristy I Azzopardi1, Alana L Whitcombe4, Reuben McGregor4, Lauren H. Carlton4, Ciara Baker1, Loraine Fabri1,5,6, Manisha Pandey7, Michael F Good7, Jonathan R. Carapetis8,9,10, Mark J Walker11,12,13, Pierre R Smeesters1,2,5,6, Paul V Licciardi2,14, Nicole J Moreland4 *, Danika L Hill15 *, Andrew C Steer1,2,3 *</p> <p>Provided in the RData file are the following items: </p> <p><strong>Dataframes: </strong></p> <p>"outcome" : clinical variables associated with human challenge for each participant</p> <p>"data" : ELISA and functional antibody responses for human challenge participants. Each timepoint and isotype for each antigen as seperate column)</p> <p>"data_long": Data equivalent to "data" file but in long format, i.e. One column for each antigen, timepoint and isotype as factors. </p> <p>"data.melt" : Data equivalent to "data" file but in longer format , i.e. timepoint, isotype and antigen as factors, 'value' as ELISA AU. </p> <p>"luminex" : IgG responses to 6 antigens analysed by luminex bead-based assay in human challenge participants.</p> <p>"luminex.children" : IgG responses to 6 antigen analysed by luminex bead-based assay in children</p> <p><strong>Vectors:</strong></p> <p>"pharyngitis" : participant "id" for the 19 individuals that developed pharyngitis. </p> <p>"Antigen.Order" : relates to "Main" antigen classification used in Figure 2</p> <p>'additional" : relates to "Additional </p> <p><strong>Function: </strong></p> <p>"custom_theme" : used as a theme when using ggplot to graph. </p> <p>Adobe Illustrator or Inkscape were used to generate the final image files for publication, with some graph editing to axes labels, font size, adding p-values etc. </p> <p> </p> <p><em><strong>Additional files: </strong></em></p> <p> 3 .csv files have been included for download</p> <p>"ELISA_data_wide_format.csv", a wide format data table of 25 human challenge individuals and 219 variables. Equivalent to the 'data' dataframe in the RData file</p> <p>"CHIVAS_luminex.csv", a long format data table of 25 human challenge participants at 1 week, 1 month, and 3 months. Equivalent to the 'luminex' dataframe in the RData file. </p> <p>"Luminex.children.csv", a datatable of 6 luminex variables for 39 children (healthy and post pharyngitis). Equivalent to the 'luminex.children' dataframe in the RData file. </p> <p> </p>
Targeting Plasmodium falciparum chondroitin sulfate a ligand: A highly conserved malaria antigen with potential for pregnancy-associated malaria vaccine development
<p>The dataset represents the details of sera samples collected from participants recruited for a longitudinal study. The sera was used for ELISA <em>in vitro</em> assays. The immunoreactivity of PfCSA-L antigen was assessed with the utilization of the gravidity status of the study participants. The antigen is used by the <em>plasmodium falciparum</em> parasite to adhere to the placenta during pregnancy and causes challenges both to the mother and her fetus.</p> <h5>Variables</h5> <ul> <li> <p>Sample_ID - This is the coded details of the study participant.</p> </li> <li> <p>Mean*od <em>_1st_visit, Mean</em>od <em>_2nd_visit, and Mean</em>od *_3rd_visit - These represent the mean reactivity values for antibody (IgG) to PfCSA-L antigen for antenatal visits 1,2 and 3 respectively.</p> </li> <li> <p>Gravida - Refers to the total number of confirmed pregnancies a female has had, regardless of the outcome of the pregnancy.</p> </li> <li> <p>PCR_Results - these are molecular diagnostic results for <em>Plasmodium falciparum</em> to assess whether the study participants were positive or negative for this species. positive = 1 and negative = 0</p> </li> <li> <p>Gestation..weeks - Refers to how far along the pregnancy is, from the first day of the woman's last menstrual cycle to the delivery</p> </li> <li> <p>Newborn outcome - Describes the health status of the childlren when they were born</p> </li> <li> <p>Gravida_class - Describes the different classes of gravida, such that primigravida means single pregnancy, secundigravida-second pregnancy, and tertigravida-third pregnancy</p> </li> <li> <p>Age - Describes the age of the participants recruited for the study</p> </li> <li> <p>HB_level - Describes the amount of hemoglobin in whole blood expressed in grams per deciliter (g/dl) during<br>enrolment</p> </li> <li> <p>Type of delivery - A spontaneous vaginal delivery (SVD) describes when a pregnant female goes into labor without the use of drugs or techniques to induce labor, and delivers her baby in the normal manner, without forceps, vacuum extraction, or a cesarean section (cs)</p> </li> <li> <p>N/A - Missing values for different variables</p> </li> </ul>
Flow cytometry data and image data -A dendritic cell vaccine for both vaccination and neoantigen-reactive T cell preparation for cancer immunotherapy in mice
Open the record for dataset details and reuse information.
Simulation results for "COVID-19 vaccination in Sindh Province, Pakistan: a modelling study of health impact and cost-effectiveness"
<p>The high-performance computing results for raw epidemiological simulations and quantiled scenarios associated with https://doi.org/10.1101/2021.02.24.21252338.</p> <p>All results stored as compressed rds files of data.table objects (use-able as data.frame objects) for use with R programming language.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.