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906
datasets available to search
ShareScore release 0.9.0
Dataset results
906 results for “atherosclerosis”
Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study
ClinicalTrials.gov study NCT00497887. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis Versus Stenting
ClinicalTrials.gov study NCT01436123. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Type 2 Diabetes Mellitus and Atherosclerosis
ClinicalTrials.gov study NCT01250340. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment
ClinicalTrials.gov study NCT00400543. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vaccine Against Atherosclerosis in Patients With Overweight Problems or Obesity
ClinicalTrials.gov study NCT03042741. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis
ClinicalTrials.gov study NCT02417688. IPD Sharing: YES. Countries: 1. Publications: 2.
Alcohol and Atherosclerosis Pilot Study
ClinicalTrials.gov study NCT00786279. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effect of Early Administration of PCSK9 Inhibitor to Acute Ischemic Stroke Patients Associated With Atherosclerosis on the Stroke Prognosis and Lipid Profile
ClinicalTrials.gov study NCT06083961. IPD Sharing: NO. Countries: 1. Publications: 13.
Relationship Between Serum Vitamin D and Atherosclerosis in Hemodialysis Patients
ClinicalTrials.gov study NCT07200804. IPD Sharing: YES. Countries: 1. Publications: 0.
Effects of Vildagliptin/Metformin Combination on Markers of Atherosclerosis, Thrombosis, and Inflammation in Diabetics With Coronary Artery Disease
ClinicalTrials.gov study NCT01604213. IPD Sharing: Not stated. Countries: 1. Publications: 6.
The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial
ClinicalTrials.gov study NCT03542110. IPD Sharing: NO. Countries: 1. Publications: 16.
99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
ClinicalTrials.gov study NCT02667457. IPD Sharing: YES. Countries: 1. Publications: 0.
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis
ClinicalTrials.gov study NCT02458755. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vein-Coronary Atherosclerosis And Rosiglitazone After Bypass Surgery: The VICTORY Trial
ClinicalTrials.gov study NCT00169832. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Prevalence of Subclinical Atherosclerosis and Its Associated Factors in Hyperlipidemic Korean Adults With Diabetes
ClinicalTrials.gov study NCT01264263. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Skin autofluorescence and subclinical atherosclerosis in mild to moderate chronic kidney disease: a case-control study
Open the record for dataset details and reuse information.
Data from: Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production
Open the record for dataset details and reuse information.
Association of chronic inflammation and accelerated atherosclerosis among an indigenous black population with chronic kidney disease
<p>Introduction: Inflammation plays a major role in the development of atherosclerosis and cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. Toll-like receptor-4 (TLR4) is a major receptor for lipopolysaccharides (endotoxin) and other ligands involved in the pathogenesis of inflammation. We determined whether endotoxin levels and the presence of TLR4 polymorphisms are associated with markers of inflammation and atherosclerosis among South African CKD patients.</p> <p><br> Materials and methods: Endotoxin, lipopolysaccharide binding protein (LBP), serum CD14 (sCD14), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and carotid intima media thickness (CIMT) were measured in 160 participants (120 CKD patients and 40 controls). Associations between endotoxins and CIMT in the presence of sCD14, IL-8 and MCP-1, were assessed using odds ratios. Participants were screened for the presence of Asp299Gly and Thr399Ile TLR4 polymorphisms, and CIMT and inflammatory markers were compared between subjects with and without TLR4 polymorphisms.</p> <p>Results: Endotoxin levels correlated with sCD14 (r=0.441, p<0.001) and MCP-1 (r=0.388, p<0.001) levels while increased CIMT was associated with MCP-1 (r=0.448, p<0.001), sCD14 levels (r=0.476, p<0.001), LBP (r=0.340, p<0.001), and IL-8 (r=0.395, p<0.001). Atherosclerosis was associated with endotoxin levels (odds ratio: 4.95; 95% confidence interval: 2.52-9.73; p<0.001), and was predicted by higher serum levels of inflammatory markers. Analysis of patients with TLR4 polymorphisms showed reduced serum levels of inflammatory markers and CIMT values compared with the patients carrying the wild type TLR4 alleles.</p> <p>Conclusion: The study demonstrated associations between circulating endotoxaemia, systemic inflammation and accelerated atherosclerosis among South African CKD patients, and showed that the atherogenic predictive power of endotoxaemia was significantly increased by the presence of elevated levels of inflammatory markers. Additional findings, which must be confirmed, suggest that TLR4 polymorphisms are associated with low levels of inflammatory markers and CIMT values.</p>
Comprehensive investigation of circulating biomarkers and their causal role in atherosclerosis-related risk factors and clinical events
<p><strong>Background</strong>: Circulating biomarkers have been previously associated with atherosclerosis-related risk factors, but the nature of these associations is incompletely understood.</p> <p><strong>Methods</strong>: We performed multivariable-adjusted regressions and 2-sample Mendelian randomization analyses to assess observational and causal associations of 27 circulating biomarkers with 7 cardiovascular traits in up to 451 933 participants of the UK Biobank.</p> <p><strong>Results</strong>: After multiple-testing correction (alpha=1.3Å~10−4), we found a total of 15, 9, 21, 22, 26, 24, and 26 biomarkers strongly associated with coronary artery disease, ischemic stroke, atrial fibrillation, type 2 diabetes, systolic blood pressure, body mass index, and waist-to-hip ratio; respectively. The Mendelian randomization analyses confirmed strong evidence of previously suggested causal associations for several glucose- and lipid-related biomarkers with type 2 diabetes and coronary artery disease. Particularly interesting findings included a protective role of IGF-1 (insulin-like growth factor 1) in systolic blood pressure, and the strong causal association of lipoprotein(a) in coronary artery disease development (β, −0.13; per SD change in exposure and outcome and odds ratio, 1.28; P=2.6Å~10−4 and P=7.4Å~10−35, respectively). In addition, our results indicated a causal role of increased ALT (alanine aminotransferase) in the development of type 2 diabetes and hypertension (odds ratio, 1.59 and β, 0.06, per SD change in exposure and outcome; P=4.8Å~10−11 and P=6.0Å~10−5). Our results suggest that it is unlikely that CRP (C-reactive protein) and vitamin D play causal roles of any meaningful magnitude in development of cardiometabolic disease.</p> <p><strong>Conclusions</strong>: We confirmed and extended known associations and reported several novel causal associations providing important insights about the cause of these diseases, which can help accelerate new prevention strategies.</p>
Mechano-sensitive super-enhancers govern atherosclerosis-linked genes in vascular endothelial cells
<p>Supplemental Table S1-2 of the manuscript in submission</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.