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12,751 results for “blood”
Differentially-expressed genes in blood in response to lipopolysaccharide in three rodent species
<p>Infection tolerance in rodents was examined by injecting single-dose lipopolysaccharide (LPS) to induce inflammation in <span><em>Peromyscus</em> <em>leucopus</em></span><span> (LL stock), the white-footed deermouse also reservoir for Lyme disease and </span><span><em>Mus</em> <em>musculus</em></span><span> (outbred CD-1 breed), the house mouse, and </span><span><em>Rattus</em> <em>norvegicus</em></span><span>, the brown rat (Fischer strain). Reaction to LPS was analyzed in the blood of challenged rodents and compared to control animals. As natural reservoirs of zoonoses deermice show significant anti-inflammatory response as described in "An Infection-Tolerant Mammalian Reservoir for Several Zoonotic Agents Broadly Counters the Inflammatory Effects of Endotoxin" (</span><a href="https://doi.org/10.1128/mBio.00588-21)" rel="noopener"><span>https://doi.org/10.1128/mBio.00588-21)</span></a><span>. The project and the description of the samples are described under the following NCBI BioProjects: PRJNA975149 (</span><a href="https://www.ncbi.nlm.nih.gov/bioproject/PRJNA975149" rel="noopener"><span>https://www.ncbi.nlm.nih.gov/bioproject/PRJNA975149)</span></a><span> for mouse and deermouse and PRJNA973677 (</span><a href="https://www.ncbi.nlm.nih.gov/bioproject/PRJNA973677)" rel="noopener"><span>https://www.ncbi.nlm.nih.gov/bioproject/PRJNA973677)</span></a><span>. This project is a follow-up project focusing on the transcriptomic analysis of the whole blood bulk RNA-seq and further analysis of differentially expressed genes (DEG) between the treatment arm and controls. Complete fold change and false discovery rate for all three rodent species used for the current Dryad set are previously published (<a href="https://doi.org/10.7280/D1470Z">https://doi.org/10.7280/D1470Z</a>). Here we report that deermice tolerance to infection is partly due to lower expression of interferon-gamma in comparison to mice and rats. <br></span></p>
Genotype of expression quantitative loci (eQTL) analyses for bovine blood and liver
<p>To identify expression quantitative loci (eQTL) operating in bovine blood and liver, 238 animals were genotyped uisng Illumina BovineHD genotyping arrary. For this file minor allele is used as ref as the default in plink.</p>
Data from: Automatic patient-level recognition of four Plasmodium species on thin blood smear by a Real Time Detector Transformer (RT-DETR) object detection algorithm: a proof-of-concept and evaluation
<p>Automatic patient-level recognition of four <em>Plasmodium</em> species on thin blood smear by a Real Time Dectector Transformer (RT-DETR) object detection algorithm: a proof-of-concept and evaluation</p> <p>Emilie Guemas, Baptiste Routier, Théo Ghelfenstein-Ferreira, Camille Cordier, Sophie Hartuis, Bénédicte Marion, Sébastien Bertout, Emmanuelle Varlet-Marie, Damien Costa, Grégoire Pasquier</p> <p><strong>Abstract:</strong></p> <p>Malaria remains a global health problem with 247 million cases and 619,000 deaths in 2021. Diagnostic of <em>Plasmodium</em> species is important for administering the appropriate treatment. The gold-standard diagnosis from accurate species identification remains the thin blood smear. Nevertheless, this method is time-consuming and requires highly skilled and trained microscopists. To overcome these issues, new diagnostic tools based on deep learning are emerging. This study aimed to evaluate the performances of a RT-DETR (Real-Time Detection Transformer)object detection algorithm to discriminate <em>Plasmodium</em> species on thin blood smears images. The algorithm was trained and validated on a dataset consisting in 24,720 images from 475 thin blood smears corresponding to 2,002,597 labels. Performances were calculated with a test dataset of 4,508 images from 170 smears corresponding to 358,825labels coming from six French university hospital. At the patient level, the RT-DETR algorithm exhibited an overall accuracy of 79.4% (135/170) with a recall of 74% (40/54) and 81.9% (95/116) for negative and positive smears, respectively. Among <em>Plasmodium </em>positive smears, the global sensitivity was 82.7% (91/110) with a sensitivity of 90% (38/42), 81.8% (18/22) and 76.1% (35/46) for <em>P. falciparum</em>, <em>P. malariae </em>and <em>P. ovale/vivax,</em> respectively. The YOLOv5 model achieved a World Health Organization (WHO) competence level 2 for species identification. Besides, the RT-DETR algorithm may be run in real-time on low-cost devices such as a smartphone and could be suitable for deployment in low-resource setting areas where microscopy experts are lacking.</p> <p><strong>Data collection:</strong></p> <p>The training and validation dataset included 24,720 pictures taken from 475 manually May Grunwald-Giemsa (MGG)-stained thin blood smears from the Montpellier University Hospital collection and for a smaller part from the Toulouse University Hospital collection. In Montpellier, the pictures were taken with a Flexcam C1 microscope camera (Leica) attached to a Leica DM 2000 microscope and Leica DF450C microscope camera adapted with a Leica DM2500 microscope at X1000 magnification. Labelling of pictures was performed manually, and then automatically with manual correction with a Computer Visual Annotation Tools (CVAT) free software. Nine categories of labels were used: white blood cells (n=3,338), red blood cells (n=1,887,781), platelets (n=48,520), <em>Trypanosoma brucei </em>(n=2,773), and red blood cells infected by <em>P. falciparum </em>(n=43,545), <em>P. ovale </em>(n=4,651), <em>P. vivax </em>(n=4,115), <em>P. malariae </em>(n=2,849) and <em>Babesia divergens</em> (n=5,142).</p> <p>The test dataset included 4,508 pictures taken from 170 thin blood smears from the same number of patients from the Parasitology laboratories of University Hospitals of Montpellier, Toulouse, Rouen, Lille, Nantes and Saint-Louis in Paris (Table 1). Among these 170 patients, 54 were not infected, including two patients with Howell-Jolly bodies, and 116 were infected with hematozoa. For each patient, between 20 and 30 photos were taken from one thin blood smear with at least one hematozoan parasite per picture for infected patients.</p> <p>Accurate species diagnostic was made by a senior parasitologist, and for recent smears, it was confirmed by specific PCR, either performed locally (Toulouse) or at the Malaria French National Reference Center (Montpellier, Saint Louis, Rouen, Lille, Nantes).</p>
Metabolomic Profile of Cerebral Tissue After Blood-Brain Barrier Opening using Microbubble-Assisted Ultrasound: A Focus on Contralateral Side.
<p>Microbubble (MB)-assisted ultrasound (US) is an innovative modality for the non-invasive, targeted and efficient delivery of the therapeutic molecules into the brain. Previously, we reported the first metabolomic signature of blood-brain barrier opening (BBBO) induced by MB-assisted US. In the present study, the neurometabolic consequences of acoustically mediated BBBO on cerebral tissue using multimodal metabolomics approaches. Sinusoid US waves (1 MHz, peak negative pressure 0.6 MPa, burst length 10 ms, total treatment time 30 s, MB bolus dose 0.7 10<sup>5</sup> MBs/g) were applied on the right striatum (ipsilateral side). Brain was collected and both striata were then dissected 3 h, 2 days and 1 week after BBBO. After tissue preparation, the samples were analyzed using nuclear magnetic resonance spectrometry (NMRS) and high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Our findings showed a slight disruption of metabolic pathways in contralateral striata of animals. Analyses of metabolic pathways indicated change of amino acid metabolisms. In addition, tryptophan derivate dosages revealed the perturbation of a central metabolite of the kynurenin pathway (<em>i.e.</em>, 3-hydroxykynurenin). In conclusion, the acoustically mediated BBBO of the ipsilateral cerebral hemisphere induced significant change in metabolism of contralateral one.</p>
Dataset SeBluCo study: SARS-CoV-2-antibodies among German blood donors 2020 – 2022, a repetitive cross-sectional study
<p>The dataset is the result of a repetitive cross-sectional study in 28 regions in Germany on SARS-CoV-2 antibodies in residual samples of blood donors from April 2020 to April 2021, September 2021 and April/May 2022. These data were used to aide in monitoring the pandemic in Germany. Data were completely anonymised at the site of sample collection. Serological test results are accompanied by demographic data including sex, age and area of residence (assigned a level two Nomenclature des Unités Territoriales Statistiques (NUTS2)). </p><p>The file contains data (sheet "data") as well as the description of variable content and coding (sheet "variables").</p>
Data pertaining to the published article "Quantitative T1 mapping detects blood-brain barrier breakdown in apparently non-enhancing multiple sclerosis lesions" by Donatelli et al., 2023.
<p>Data pertaining to the published article "Quantitative T1 mapping detects blood-brain barrier breakdown in apparently non-enhancing multiple sclerosis lesions" by Donatelli et al., NeuroImage: Clinical (2023). </p><p>PMID: <strong>37717382; </strong>PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10514220/">PMC10514220</a>; DOI: <a href="https://doi.org/10.1016/j.nicl.2023.103509">10.1016/j.nicl.2023.103509</a></p>
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes
ClinicalTrials.gov study NCT06069206. IPD Sharing: YES. Countries: 1. Publications: 18.
Age of Blood in Sickle Cell Transfusion
ClinicalTrials.gov study NCT03704922. IPD Sharing: YES. Countries: 1. Publications: 2.
Blood Pressure Checks for Diagnosing Hypertension (BP-CHECK)
ClinicalTrials.gov study NCT03130257. IPD Sharing: YES. Countries: 1. Publications: 7.
A Study to Assess the Efficacy and Safety of BIVV009 (Sutimlimab) in Participants With Primary Cold Agglutinin Disease Without A Recent History of Blood Transfusion
ClinicalTrials.gov study NCT03347422. IPD Sharing: YES. Countries: 14. Publications: 2.
A Dose Escalation Study of a Combination Antihypertensive Drug in the Treatment of Various Groups of Patients Who do Not Respond to Single Drug Treatment of Their High Blood Pressure
ClinicalTrials.gov study NCT00791258. IPD Sharing: YES. Countries: 1. Publications: 2.
Using Romiplostim to Treat Low Platelet Counts Following Chemotherapy and Autologous Hematopoietic Cell Transplantation in People With Blood Cancer
ClinicalTrials.gov study NCT04478123. IPD Sharing: YES. Countries: 1. Publications: 1.
Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease
ClinicalTrials.gov study NCT03395639. IPD Sharing: YES. Countries: 14. Publications: 1.
Gut Butyrate and Blood Pressure in African Americans
ClinicalTrials.gov study NCT04415333. IPD Sharing: YES. Countries: 1. Publications: 5.
A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants
ClinicalTrials.gov study NCT06454630. IPD Sharing: YES. Countries: 5. Publications: 1.
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
ClinicalTrials.gov study NCT05618808. IPD Sharing: YES. Countries: 7. Publications: 1.
Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots.
ClinicalTrials.gov study NCT00986154. IPD Sharing: YES. Countries: 38. Publications: 8.
SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart i
ClinicalTrials.gov study NCT02813473. IPD Sharing: YES. Countries: 5. Publications: 2.
Whole Blood Platelet Aggregation in Chronic Kidney Disease Patients on Aspirin Study
ClinicalTrials.gov study NCT01768637. IPD Sharing: YES. Countries: 1. Publications: 2.
CARDIA-Salt Sensitivity of Blood Pressure (SSBP)
ClinicalTrials.gov study NCT04258332. IPD Sharing: YES. Countries: 1. Publications: 1.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.