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Fig. 9 in Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity
Fig. 9. (A) Effects of 1–4 on RANKL-induced osteoclast differentiation of RAW 264 cells. RAW 264 cells were treated with RANKL (50 ng/mL) in the presence or absence of 1–4 at the indicated concentrations and cultured for 4 d. The cells were stained using TRAP-staining solution, and the number of TRAP-positive multinuclear (>3 nuclei) cells was counted. Experiments were performed in triplicate, error bars stand for standard deviation, and asterisks show significant differences at P <0.005 according to the Student's t-test. (B) TRAP-stained RAW 264 cells incubated with 50 ng/mL RANKL in the presence or absence of 3 and 4 (20 μM). Scale bar represents 200 nm.
Fig. 6 in Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity
Fig. 6. (A) Experimental ECD spectra of 1, 1a, and 1b and calculated ECD spectra of 3R,6S,7S,3′R,6′S-1 and its 7-epimer. (B) Experimental ECD spectra of 2, 2a, and 2a/2b (1:3) and calculated ECD spectra of 3R,6S,7S,3′R,6′R-2 and its 7-epimer.
Fig. 4 in Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity
Fig. 4. (A) Retrosynthesis of 1/2 from hemiacetal 7 and hydroperoxide 8. (B) Synthesis of 1a/2a from R-linalool and 4. (C) Synthesis of 1a/2a and 1 b/2b from RSlinalool and 4.
Fig. 7 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 7. Formation of 3-benzyl-4-hydroxy-2-thioxothiazolidine-4-carboxylic acid (12) from benzylisothiocyanate (11) in mammals.
Fig. 1 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 1. Formation of isothiocyanates (ITCs) from glucosinolates (GLCs) via Lossen type rearrangement is mediated by myrosinases in plants of the order Brassicales.
Fig. 10 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 10. Proposed pathways for transformation of rapalexin A (1) to N-acetyl-S-(8-methoxy-4H-thiazolo[5,4-b]indol-2-yl)-L-cysteine (5, tR = 7.1 min) and 4-hydroxy-3-(4-methoxy-1H-indol-3-yl)-2-thioxothiazolidine-4-carboxylic acid (9, tR = 3.4 min) mediated by Colletotrichum dematium and C. higginsianum and degradation of 9; two arrows indicate more than one step; square brackets indicate potential intermediate; Ea = electron acceptor.
Fig. 3 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 3. Selected HMBC correlations of N-acetyl-S-(8-methoxy-4H-thiazolo[5,4- b]indol-2-yl)cysteine (5, tR = 7.1 min).
Fig. 2 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 2. Detoxification of the cruciferous phytoalexin brassinin (2) to indolyl-3-methanamine (4) and indole-3-carboxaldehyde (3) by the plant fungal pathogens Alternaria brassicicola (A. b.) and Leptosphaeria maculans (L. m.), respectively.
Fig. 6 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 6. Selected HMBC correlations and rotamers of 4-hydroxy-3-(4-methoxy-1H-indol-3-yl)-2-thioxothiazolidine-4-carboxylic acid (9) (tR = 3.4 min) and proposed decomposition of 9 to 1 and β-mercaptopyruvic acid.
Fig. 9 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 9. Synthesis of 4-hydroxy-3-benzyl-2-thioxothiazolidine-4-carboxylic acid (12), ethyl 3-benzyl-4-hydroxy-2-thioxothiazolidine-4-carboxylate (17), 3-benzyl-2- thioxo-2,3-dihydrothiazole-4-carboxylic acid (16), and 4-hydroxy-3-(4-methoxy-1H-indol-3-yl)-2-thioxothiazolidine-4-carboxylic acid (9).
Fig. 5 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 5. Progress curves for formation of compounds with tR = 3.4 min (9) and tR = 7.1 min (5) in cultures of Colletotrichum higginsianum containing rapalexin A (1) (and) or rapalexin A (1) and L-Cys (and).
Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate
<p>Gaussian 16 output files for all computed structures in the article "Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate". <em>Organic & Biomolecular Chemistry</em>, <strong>2023</strong>, <em>21</em>, 9583-9590. <a title="Link to landing page via DOI" href="https://doi.org/10.1039/D3OB01710A">https://doi.org/10.1039/D3OB01710A</a></p>
The Effects of Supplementation of Conjugated Linoleic Acid on Body Fat Reduction
ClinicalTrials.gov study NCT03915808. IPD Sharing: NO. Countries: 1. Publications: 3.
A Study of Pneumococcal Conjugate Vaccine (V114) Compared to a Marketed Vaccine (V114-003)
ClinicalTrials.gov study NCT01215188. IPD Sharing: YES. Countries: 0. Publications: 1.
13 Valent Pneumococcal Conjugate Vaccine - Follow-on Study
ClinicalTrials.gov study NCT01095471. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Fmri Study on the Effects of a Conjugate Vaccine and Placebo on CNS Activation and Behavior Following a Nicotine Challenge
ClinicalTrials.gov study NCT01318668. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea
ClinicalTrials.gov study NCT00219401. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine in Indonesian Adults, Adolescents, Children and Infants
ClinicalTrials.gov study NCT03460405. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens
ClinicalTrials.gov study NCT04821141. IPD Sharing: NO. Countries: 1. Publications: 2.
Study on a MenACYW Conjugate Vaccine Administered as a Single Dose in Participants Aged 12 Months and Older in Vietnam
ClinicalTrials.gov study NCT06228586. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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