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601 results for “crossovers”
The Effect of Hyperoxia and Hypoxia on Fluorescence Lifetime Imaging Ophthalmoscopy in Healthy Subjects- a Randomized, Double Blind, Crossover Study
ClinicalTrials.gov study NCT04094285. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Crossover Comparison of Two Gadolinium Contrast Agents for Use With MRA of Carotid, Renal and Peripheral Arteries
ClinicalTrials.gov study NCT01260636. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
ClinicalTrials.gov study NCT06790875. IPD Sharing: NO. Countries: 1. Publications: 1.
A Crossover Trial of Chitosan Oligosaccharide on Post Prandial Glucose Control in Subjects With Normal, IFG and IGT
ClinicalTrials.gov study NCT03650023. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Crossover Safety Study of Ferumoxytol Versus Placebo
ClinicalTrials.gov study NCT00255450. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: BCI training to move a virtual hand reduces phantom limb pain: a randomized crossover trial
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Data from: The effect of meal frequency in a reduced-energy regimen on the gastrointestinal and appetite hormones in patients with type 2 diabetes: a randomised crossover study
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A comparison of new cardiovascular endurance test using the 2-minute marching test vs. 6-minute walk test in healthy volunteers: A crossover randomized controlled trial
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Data from: Ecological crossovers of sexual signalling in a migratory bird
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Data from: High-resolution estimates of crossover and noncrossover recombination from a captive baboon colony
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Data from: Reduced crossover interference and increased ZMM-independent recombination in the absence of Tel1/ATM
Meiotic recombination involves the repair of double-strand break (DSB) precursors as crossovers (COs) or noncrossovers (NCOs). The proper number and distribution of COs is critical for successful chromosome segregation and formation of viable gametes. In budding yeast the majority of COs occurs through a pathway dependent on the ZMM proteins (Zip2-Zip3-Zip4-Spo16, Msh4-Msh5, Mer3), which form foci at CO-committed sites. Here we show that the DNA-damage-response kinase Tel1/ATM limits ZMM-independent recombination. By whole-genome mapping of recombination products, we find that lack of Tel1 results in higher recombination and reduced CO interference. Yet the number of Zip3 foci in tel1Δ cells is similar to wild type, and these foci show normal interference. Analysis of recombination in a tel1Δ zip3Δ double mutant indicates that COs are less dependent on Zip3 in the absence of Tel1. Together these results reveal that in the absence of Tel1, a significant proportion of COs occurs through a non-ZMM-dependent pathway, contributing to a CO landscape with poor interference. We also see a significant change in the distribution of all detectable recombination products in the absence of Tel1, Sgs1, Zip3, or Msh4, providing evidence for altered DSB distribution. These results support the previous finding that DSB interference depends on Tel1, and further suggest an additional level of DSB interference created through local repression of DSBs around CO-designated sites.
The impact of cardiopulmonary resuscitation on a cannot intubate, cannot oxygenate condition – a randomised crossover simulation research study of the interaction between two algorithms
<p>This is the original data file of the publication entiteled:</p> <p>The impact of cardiopulmonary resuscitation on a cannot intubate, cannot oxygenate condition – A randomised crossover simulation research study of the interaction between two algorithms</p> <p> </p>
Data from: Meta‐analysis of chromosome‐scale crossover rate variation in eukaryotes and its significance to evolutionary genomics
Understanding the distribution of crossovers along chromosomes is crucial to evolutionary genomics because the crossover rate determines how strongly a genome region is influenced by natural selection. Nevertheless, generalities in the chromosome-scale distribution of crossovers have not been investigated formally. We fill this gap by synthesizing joint information on genetic and physical maps across 62 animal, plant, and fungal species. Our quantitative analysis reveals a strong and taxonomically wide-spread reduction of the crossover rate in the center of chromosomes relative to their peripheries. We demonstrate that this pattern is poorly explained by the position of the centromere, but find that the magnitude of the relative reduction in the crossover rate in chromosome centers increases with chromosome length. That is, long chromosomes often display a dramatically low crossover rate in their center whereas short chromosomes exhibit a relatively homogeneous crossover rate. This observation is compatible with a model in which crossovers are initiated from the chromosome tips, an idea with preliminary support from mechanistic investigations of meiotic recombination. Consequently, we show that organisms achieve a higher genome-wide crossover rate by evolving smaller chromosomes. Summarizing theory and providing empirical examples, we finally highlight that taxonomically wide-spread and systematic heterogeneity in crossover rate along chromosomes generates predictable broad-scale trends in genetic diversity and population differentiation by modifying the impact of natural selection among regions within a genome. We conclude by emphasizing that chromosome-scale heterogeneity in crossover rate should urgently be incorporated into analytical tools in evolutionary genomics, and in the interpretation of emerging patterns.
Data from: The kinetochore prevents centromere-proximal crossover recombination during meiosis
During meiosis, crossover recombination is essential to link homologous chromosomes and drive 22 faithful chromosome segregation. Crossover recombination is non-random across the genome, 23 and centromere-proximal crossovers are associated with an increased risk of aneuploidy, 24 including Trisomy 21 in humans. Here, we identify the conserved Ctf19/CCAN kinetochore sub- 25 complex as a major factor that minimizes potentially deleterious centromere-proximal crossovers 26 in budding yeast. We uncover multi-layered suppression of pericentromeric recombination by the 27 Ctf19 complex, operating across distinct chromosomal distances. The Ctf19 complex prevents 28 meiotic DNA break formation, the initiating event of recombination, proximal to the centromere. 29 The Ctf19 complex independently drives the enrichment of cohesin throughout the broader 30 pericentromere to suppress crossovers, but not DNA breaks. This non-canonical role of the 31 kinetochore in defining a chromosome domain that is refractory to crossovers adds a new layer 32 of functionality by which the kinetochore prevents the incidence of chromosome segregation 33 errors that generate aneuploid gametes.
Data from: Controlling meiotic recombinational repair: specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation
Crossovers (COs) play a critical role in ensuring proper alignment and segregation of homologous chromosomes during meiosis. How the cell balances recombination between CO vs. noncrossover (NCO) outcomes is not completely understood. Further lacking is what constrains the extent of DNA repair such that multiple events do not arise from a single double-strand break (DSB). Here, by interpreting signatures that result from recombination genome-wide, we find that synaptonemal complex proteins promote crossing over in distinct ways. Our results suggest that Zip3 (RNF212) promotes biased cutting of the double Holliday-junction (dHJ) intermediate whereas surprisingly Msh4 does not. Moreover, detailed examination of conversion tracts in sgs1 and mms4-md mutants reveal distinct aberrant recombination events involving multiple chromatid invasions. In sgs1 mutants, these multiple invasions are generally multichromatid involving 3–4 chromatids; in mms4-md mutants the multiple invasions preferentially resolve into one or two chromatids. Our analysis suggests that Mus81/Mms4 (Eme1), rather than just being a minor resolvase for COs is crucial for both COs and NCOs in preventing chromosome entanglements by removing 3′- flaps to promote second-end capture. Together our results force a reevaluation of how key recombination enzymes collaborate to specify the outcome of meiotic DNA repair.
To swim or not to swim after eating: a randomized controlled crossover feasibility trial
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Spin-Crossover Grafted Monolayer of a Co(II) Terpyridine Derivative Functionalized with Carboxylic Acid Groups
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Data Repo for "Crossover of high-energy spin fluctuations from collective triplon excitations to incoherent gapped magnetic modes in the cuprate ladders of Sr14-xCaxCu24O41"
<p>Data set for the paper "Crossover of high-energy spin fluctuations from collective triplon excitations to incoherent gapped magnetic modes in the cuprate ladders of Sr14-xCaxCu24O41"</p> <p>Preprint Available at: https://arxiv.org/abs/2201.05027</p> <p> </p>
ICF_2024: Multielectron transfer and field-induced slow magnetic relaxation in opto-electroactive spin crossover cobalt(II) complexes: structure-function correlations
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Data set for Two- to three-dimensional crossover in a dense electron liquid in silicon
<p>Data set for Two- to three-dimensional crossover in a dense electron liquid in silicon paper</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.