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1,908 results for “dexamethasone”
Genotype stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative Adults: the LAST ACT trial
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Dexamethasone inhibits Mycobacterium tuberculosis-induced glycolysis but preserves antimicrobial function in primary human macrophages.
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Dexamethasone Acetate-Loaded PLGA NanospheresTargeting Liver Macrophages
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Aldosterone and dexamethasone activate African lungfish mineralocorticoid receptor: Increased activation after removal of the amino-terminal domain
<p><span><span><span><span><span><span><span><span><span><span><span>Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by vertebrates. We studied transcriptional activation of the slender African lungfish MR by aldosterone, other corticosteroids and progesterone and find that aldosterone, 11-deoxycorticosterone, 11-deoxycortisol and progesterone have half-maximal responses (EC50s) below 1 nM and are potential physiological mineralocorticoids. In contrast, EC50s for corticosterone and cortisol were 23 nM and 66 nM, respectively. Unexpectedly, truncated lungfish MR, consisting of the DNA-binding, hinge and steroid-binding domains, had a stronger response to corticosteroids and progesterone than full-length lungfish MR, indicating that the N-terminal domain represses steroid activation of lungfish MR, unlike human MR in which the N-terminal domain contains an activation function. BLAST searches of GenBank did not retrieve a GR ortholog, leading us to test dexamethasone and triamcinolone for activation of lungfish MR. At 10 nM, both synthetic glucocorticoids are about 4-fold stronger than 10 nM aldosterone in activating full-length lungfish MR, leading us to propose that lungfish MR also functions as a GR.</span></span></span></span></span></span></span></span></span></span></span></p>
Study of Daratumumab in Combination With Dexamethasone in Resistant or Refractory Multiple Myeloma
ClinicalTrials.gov study NCT02626481. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Filanesib (ARRY-520) in Combination With Pomalidomide and Dexamethasone for Relapsed/Refractory (R/R) Multiple Myeloma (MM) Patients
ClinicalTrials.gov study NCT02384083. IPD Sharing: Not stated. Countries: 1. Publications: 20.
Ranibizumab vs Dexamethasone Implant in Vitrectomized Eyes With Diabetic Macular Edema
ClinicalTrials.gov study NCT04089605. IPD Sharing: NO. Countries: 1. Publications: 3.
Oral Versus Intravenous Dexamethasone
ClinicalTrials.gov study NCT01390012. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dexmedetomidine and Dexamethasone as an Adjuvant to Ropivacaine in Thoracic Surgery
ClinicalTrials.gov study NCT03632460. IPD Sharing: NO. Countries: 1. Publications: 3.
A Study of JNJ-54767414 (Daratumumab) in Combination With Lenalidomide and Dexamethasone in Japanese Participants With Previously Untreated Multiple Myeloma Who Are Ineligible for High-dose Therapy an
ClinicalTrials.gov study NCT02918331. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants
ClinicalTrials.gov study NCT05455320. IPD Sharing: YES. Countries: 18. Publications: 0.
The Optimal Time of IV Dexamethasone Administration for Prolongation of Peripheral Nerve Block
ClinicalTrials.gov study NCT03394820. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
ClinicalTrials.gov study NCT05002361. IPD Sharing: Not stated. Countries: 1. Publications: 1.
S9628 Dexamethasone Plus Interferon Alfa in Treating Patients With Primary Systemic Amyloidosis
ClinicalTrials.gov study NCT00002849. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Adjuvant Dexamethasone on Postoperative Pain, Analgesic Consumption and Block Properties in SFIB
ClinicalTrials.gov study NCT05979597. IPD Sharing: NO. Countries: 1. Publications: 4.
The Effect of Dexamethasone in Full Pulpotomy on Postoperative Pain in Permanent Molars
ClinicalTrials.gov study NCT07233577. IPD Sharing: NO. Countries: 1. Publications: 3.
Piezo-surgery Technique and Intramuscular Dexamethasone Injection to Reduce Postoperative Pain After Impacted Mandibular Third Molar Surgery
ClinicalTrials.gov study NCT04889781. IPD Sharing: NO. Countries: 1. Publications: 1.
Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia
ClinicalTrials.gov study NCT04344730. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Pediatric Postoperative Analgesia With Quadratus Lumborum Block(QLB) And Dexamethasone As An Adjuvant To Bupivacaine.
ClinicalTrials.gov study NCT04963816. IPD Sharing: NO. Countries: 1. Publications: 1.
Block Duration After Spinal Block and iv Dexamethasone.
ClinicalTrials.gov study NCT03527576. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.