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311 results for “function dataset”
Dataset #2 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
<p><span>CD8<sup>+</sup> T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8<sup>+</sup> T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8<sup>+</sup> T-cell culture induced potent effector differentiation, IFN-</span><span>g</span><span> production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8<sup>+</sup> T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8<sup>+</sup> T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8<sup>+</sup> T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8<sup>+</sup> T-cell effector function, with potential translation in cancer immunotherapy.</span></p>
Dataset for the article "Structural and Functional Insights into Oxidized and Hydrogenated HPHT Nanodiamonds for Cortisol Immunosensor Applications".
<p>Dataset for the article "Structural and Functional Insights into Oxidized and Hydrogenated HPHT Nanodiamonds for Cortisol Immunosensor Applications</p> <p>Chakavak Esmaeili1, Štěpán Stehlík2, Martin Krejci3, Bohuslav Rezek1</p> <p>1 Faculty of Electrical Engineering, CTU in Prague, Technicka 2, 16627 Prague, Czech Republic</p> <p>2 Institute of Physics of the Czech Academy of Sciences, Cukrovarnická 10, 162 00 Prague, Czech Republic</p> <p>3 FHNW University of Applied Sciences and Arts Northwestern Switzerland School of Engineering Klosterzelgstrasse 2<br>CH-5210 Windisch</p> <p> </p> <p>Fig 1A. SEM images of (a) the carbon bare electrode (b) before and (c) after rinsing of 3 µg HPHT-O<br>Fig 1B. SEM image of (a) the carbon bare electrode (b) before and (c) after rinsing of 3 µg HPHT-H<br>Fig 1C. SEM micrographs of (a) bare carbon electrode, (b) SPE/HPHT-O, (c) SPE/HPHT-O/APTES, (d) SPE/HPHT-O/APTES/EDC NHS, (e) SPE/HPHT-O/APTES/EDC NHS/Ab, (f) SPE/HPHT-O/APTES/EDC NHS/Ab/BSA, (g) SPE/HPHT-O/APTES/EDC NHS/Ab/BSA/Ag (with original magnification 2.00KX (up) and 15.00KX (down) at 5 kV)<br>Fig 2. The preparation and immobilization step of the cortisol fabrication based on electrochemical immunosensor <br>Fig 3. Functionalization step. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/APTES, (4) electrode/HPHT-O/APTES/EDC NHS, at pH 7.0, containing 250 mM KCl and 5 mM K3[Fe(CN)6] and 5 mM K4[Fe(CN)6], Scan rate 0.1Vs−1<br>Fig 4. Sensing steps. a) CV and b) DPV results for (4) electrode/HPHT-O/APTES/EDC NHS, (5) electrode/HPHT-O/APTES/EDC NHS/Ab, (6) electrode/HPHT-O/APTES/EDC NHS/Ab/BSA, and (7) electrode/HPHT-O/APTES/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 5. a) CV and b) DPV results for (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/APTES, (4) electrode/HPHT-O/APTES/Ab, (5) electrode/HPHT-O/APTES/Ab/BSA, and (6) electrode/HPHT-O/APTES /Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 6. a) CV and b) DPV results for (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/EDC NHS, (4) electrode/HPHT-O/ EDC NHS /Ab, (5) electrode/HPHT-O/ EDC NHS /Ab/BSA, and (6) electrode/HPHT-O/ EDC NHS /Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 7. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/APTES, (4) electrode/HPHT-H/APTES/EDC NHS, (5) electrode/HPHT-H/APTES/EDC NHS/Ab, (6) electrode/HPHT-H/APTES/EDC NHS/Ab/BSA, and (7) electrode/HPHT-H/APTES/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 8. Variation of the immunosensor response against the cortisol concentrations in the range of 1.0 ng to 0.5 ng/mL at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 9. Interference study involving progesterone (2430 pg/ml), β-oestradiol (32 pg/ml), cortisone (28.6 nM), and corticosterone (3.94 nM) with respect to cortisol (1 ng/mL)</p> <p><br>Fig S1. Optical images obtained for (a) before and (b) after rinsing of 3.0µg HPHT-H<br>Fig S2. Optical images obtained for (a) bare carbon electrode, (b) HPHT-O, (c) HPHT-O/APTES, (d) HPHT-O/APTES/EDC NHS, (e) HPHT-O/APTES/EDC NHS /Ab, (f) HPHT-O/APTES/EDC NHS /Ab/BSA, (g) HPHT-O/APTES/EDC NHS /Ab/BSA/Ag<br>Fig S3. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/APTES, (4) electrode/HPHT-H/APTES/Ab, (5) electrode/HPHT-H/APTES/ Ab/BSA, and (6) electrode/HPHT-H/APTES/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S<br>Fig S4. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/EDC NHS, (4) electrode/HPHT-H/EDC NHS/Ab, (5) electrode/HPHT-H/EDC NHS/ Ab/BSA, and (6) electrode/HPHT-H/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S<br>Fig S5. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/APTES, (3) electrode/APTES/EDC NHS, (4) electrode/APTES/EDC NHS/Ab, (5) electrode/APTES/EDC NHS/Ab /BSA, and (6) electrode/APTES/EDC NHS/Ab/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S</p> <p> </p> <p><br>Table 1. Summary of the DPV electrochemical performance of the HPHT-O modified electrode using APTES and EDC-NHS as crosslinkers in cortisol immunosensor detection<br>Table 2. Summary of the DPV electrochemical performance of the HPHT-O modified electrode utilizing APTES without EDC-NHS as a crosslinker in cortisol immunosensor detection.<br>Table 3. Summary of the DPV electrochemical performance of the HPHT-O modified electrode utilizing EDC-NHS without APTES as a crosslinker in cortisol immunosensor detection<br>Table 4. Determination of cortisol in artificial human saliva.</p>
Dataset related to the poster entitled "Vitamin D3 deficiency disturbed immune response and respiratory function in the murine model of hypersensitivity pneumonitis"
<p><strong>The dataset contains the results presented on a poster presented at the European Academy of Allergy and Clinical Immunology Hybrid Congress, 31 May – 3 June 2024, Valencia, Spain<br><br></strong></p> <p><em>Project title</em><strong>:</strong> "Assessment of the possibility of using vitamin D3 in the prevention and treatment of pulmonary fibrosis in the course of hypersensitivity pneumonitis - <em>in vivo</em> studies"</p> <p><em>Founder</em><strong>: </strong>National Scientific Center, Poland</p> <p><em>Project number</em><strong>:</strong> UMO-2020/38/E/NZ7/00366</p> <p><em>Principal Investigator</em>: Marta Kinga Lemieszek</p> <p><em>Main investigators:</em><strong> </strong>Michał Chojnacki, Ilona Leśniowska, Jakub Anisiewicz</p> <p><em>Place of project implementation</em><strong>:</strong> Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland</p>
Dataset associated to: Controlling the Carbon-Bio Interface via Glycan Functional Adlayers for Applications in Microbial Fuel Cell Bioanodes
<p>This file contains the dataset associated to the published research article "Controlling the Carbon-Bio Interface via Glycan Functional Adlayers for Applications in Microbial Fuel Cell Bioanodes". The dataset contains Atomic Force Microscopy, electrochemistry, Microbial Fuel Cells power output, water contact angle and quartz crystal microbalance raw data from their relative instruments. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 799175 (HiBriCarbon). This publication has also emanated from research conducted with the financial support of Science Foundation Ireland under Grant No. 13/CDA/2213 and 19/FFP/6761. The authors thank the France-Ireland PHC ULYSSES programme for support, project 36028UB. F.B. thanks Rennes Métropole for the co-funding of a Quartz Crystal Microbalance. T.P. thanks Région Bretagne for the co-funding of his PhD.</p>
A long-term monthly dataset of cloud fraction over the Arctic based on multiple satellite products using cumulative distribution function matching and Bayesian maximum entropy
<p>The low accuracy of satellite Cloud fraction (CF) over the Arctic seriously restricts accurate assessment of regional and global radiant energy balance under the changing climate. Previous studies have reported that not a single satellite CF product could satisfy the needs of accuracy and spatio-temporal coverage simultaneously for long-term applications over the Arctic. Merging multiple CF products with complementary properties is an effective way to produce more spatiotemporally complete and accurate CF data record. This study proposed a spatiotemporal statistical data fusion framework based on cumulative distribution function (CDF) matching and Bayesian maximum entropy (BME) method to produce a syncretic 1°×1° CF dataset in the Arctic during 2000-2020. The original datasets contain CF from MOD08/MYD08, CERES-SSF Terra/Aqua, CLARA-A2 AM/PM, PATMOS-x AM/PM, ISCCP-H AM/PM. The fused CF product is more consistent with the active satellite data GEWEX-CALIPSO and the ground-based observation data CRU TS4.05.</p>
Modeling hydraulic heads with impulse response functions in different environmental settings (dataset and code supplement)
<p>These folders contain the input data, the scripts, and the output to reproduce the results and figures of Jemeljanova et al. "Modeling hydraulic heads with impulse response functions in different environmental settings".<br> </p> <p>This research is funded by the Latvian Council of Science, project “Spatial and temporal prediction of groundwater drought with mixed models for multilayer sedimentary basin under climate change”, project No. lzp-2019/1-0165 and PostDoc research project agreement No. 1.1.1.2/VIAA/3/19/524.</p>
Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
<p><span>CD8<sup>+</sup> T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8<sup>+</sup> T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8<sup>+</sup> T-cell culture induced potent effector differentiation, IFN-</span><span>g</span><span> production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8<sup>+</sup> T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8<sup>+</sup> T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8<sup>+</sup> T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8<sup>+</sup> T-cell effector function, with potential translation in cancer immunotherapy.</span></p>
Data from: Assessing among-lineage variability in phylogenetic imputation of functional trait datasets
Open the record for dataset details and reuse information.
Dataset from: Functional divergence of mammalian TFAP2a and TFAP2b transcription factors for bidirectional sleep control
Open the record for dataset details and reuse information.
Conserved functional antagonism between CELF and MBNL proteins regulates stem cell-specific alternative splicing and regeneration in planarians (dataset 1)
GEO Series GSE75296. Schmidtea mediterranea. 11 samples. Type: Expression profiling by high throughput sequencing.
Systematic Discovery and Characterization of Chromatin States and Butyrate-induced Variations for Cattle Genome Functional Annotation [dataset 6]
GEO Series GSE129421. Bos taurus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dopaplex RNA-seq dataset for "A dopamine-induced coordinated gene expression program regulates neuronal function and cocaine response"
GEO Series GSE137658. Rattus norvegicus. 11 samples. Type: Expression profiling by high throughput sequencing.
Systematic Discovery and Characterization of Chromatin States and Butyrate-induced Variations for Cattle Genome Functional Annotation [dataset 5]
GEO Series GSE129420. Bos taurus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Age-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 4)
GEO Series GSE62374. Homo sapiens. 32 samples. Type: Expression profiling by array.
Striatal cultured neurons single-nucleus RNA-seq dataset for "A dopamine-induced coordinated gene expression program regulates neuronal function and cocaine response"
GEO Series GSE137759. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Unraveling the dataset transcriptomic response of Hydrangea macrophylla stem to mechanical stimulation: de novo assembly and functional annotation
GEO Series GSE238196. Hydrangea macrophylla. 27 samples. Type: Expression profiling by high throughput sequencing.
ATAC-seq datasets for chromatin accessibility quantification in "Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems"
GEO Series GSE150589. Rattus norvegicus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Systematic Discovery and Characterization of Chromatin States and Butyrate-induced Variations for Cattle Genome Functional Annotation [dataset 1]
GEO Series GSE129416. Bos taurus. 6 samples. Type: Expression profiling by high throughput sequencing.
Human Endogenous Retrovirus-K in Stem Cell Function and Neuronal Differentiation [dataset 2]
GEO Series GSE110497. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Targeted experimentation to increase functional coverage in omics dataset
GEO Series GSE73672. Escherichia coli BW25113. 87 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.