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220
datasets available to search
ShareScore release 0.9.0
Dataset results
220 results for “functional sequencing”
Optimisation of the self-transcribing active regulatory region sequencing massively parallel reporter assay for the functional interrogation of cis-regulatory regions
GEO Series GSE247172. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Integrative analysis of long isoform sequencing and functional data identifies distinct cortical layer neuronal subtypes derived from human iPSC
GEO Series GSE274249. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide Functional Characterization of Escherichia coli Promoters and Sequence Elements Encoding Their Regulation
GEO Series GSE144621. Escherichia coli DH5[alpha]; Escherichia coli str. K-12 substr. MG1655. 60 samples. Type: Other; Expression profiling by high throughput sequencing.
Replacement of Arabidopsis H2A.Z with human H2A.Z orthologs reveals extensive functional conservation and limited importance of the N-terminal tail sequence for Arabidopsis development (WT, h2a.z, h2a
GEO Series GSE263310. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing.
Single-cell sequencing technology demonstrates cellular and functional heterogeneity within the prostate and between the transitional and peripheral zones
GEO Series GSE166782. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis
GEO Series GSE270517. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Characterization of sequence determinants of enhancer function using natural genetic variation
GEO Series GSE193728. Mus musculus. 264 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Single cell RNA sequencing reveals a shift in cell function and maturation of endogenous and infiltrating cell types in response to acute intervertebral disc injury
GEO Series GSE277892. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Optical imaging and single-cell RNA sequencing reveal individual heterogeneity in pancreatic cells that supports global function
<p>Islets, micro-organs critical for glucose homeostasis, exhibit significant genetic diversity among their cells, which is hypothesized to underpin their functional repertoire. Our study investigated the heterogeneity in glucose-induced excitability within islet cells, providing a cellular basis for their roles in glucose-responsive hormone secretion. To comprehensively map glucose-induced excitability profiles, we developed SHIMMER, a high-throughput, multimodal data acquisition platform that integrates electrical signals, Ca2+ fluxes, and single-cell sequencing data. By quantifying the non-stationary electrical and calcium signal dynamics, we formulated a machine learning-based electro-calcium model that shows how variations in membrane conductance and Ca2+ clearance contribute to increased heterogeneity in cytosolic Ca2+ accumulation. Using SHIMMER for single-cell sequencing on representative cells, we identified genes such as <em>Cacnb2</em> and <em>Arpp19</em>, that associated with electro-calcium characteristics, and found <em>Clec4d</em> as a potential marker for a highly excitable cell subpopulation. These findings indicate that islet cells tend to exhibit a large heterogeneity in glucose-induced excitability, being essential for their normal functioning.</p>
Optical imaging and single-cell RNA sequencing reveal individual heterogeneity in pancreatic cells that supports global function
<p>Our study investigated the heterogeneity in glucose-induced excitability within islet cells, providing a cellular basis for their roles in glucose-responsive hormone secretion. To comprehensively map glucose-induced excitability profiles, we developed SHIMMER, a high-throughput, multimodal data acquisition platform that integrates electrical signals, Ca2+ fluxes, and single-cell sequencing data. By quantifying the non-stationary electrical and calcium signal dynamics, we formulated a machine learning-based electro-calcium model that shows how variations in membrane conductance and Ca2+ clearance contribute to increased heterogeneity in cytosolic Ca2+ accumulation. Using SHIMMER for single-cell sequencing on representative cells, we identified several genes that associated with electro-calcium characteristics, and found a potential marker for a highly excitable cell subpopulation. These findings indicate that islet cells tend to exhibit a large heterogeneity in glucose-induced excitability, being essential for their normal functioning.</p> <p>This dataset include all processed data we mentioned in our paper, the code were uploaded on https://github.com/CullinanLi/heterogeneity-in-pancreatic-islet-cells, with the same folder name, if we missed anything, please feel free to contact the lead contact.</p>
B. acidifaciens-derived small RNA promotes colitis development by targeting mucin 2 to impair the gut mucosal barrier function [CD45RB high-16s-DNA-sequence]
GEO Series GSE155038. Mus musculus. 10 samples. Type: Other.
Functional division of insect blood cells in immunity by single-cell RNA sequencing
GEO Series GSE308201. Spodoptera exigua. 2 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing reveals a gene expression signature in skeletal muscle of a mouse model of age-associated post-operative functional decline
GEO Series GSE184486. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Characterization and function of Tomato yellow leaf curl virus-derived small RNAs generated in the tolerant and susceptible tomato varieties using deep sequencing
GEO Series GSE50085. Solanum lycopersicum. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Single cell RNA sequencing of myeloid cell subsets in brain trauma links targeting Ccr2-dependent macrophages with both improved functional outcomes and a reduction in type I IFN responses from TBI mi
GEO Series GSE129927. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
RNA quality control by CCR4 safeguards chromatin integrity and centromere function in Arabidopsis [Oxford Nanopore Technology Direct RNA Sequencing]
GEO Series GSE274200. Arabidopsis thaliana. 4 samples. Type: Expression profiling by high throughput sequencing.
Characterization of sequence determinants of enhancer function using natural genetic variation [CUT&RUN]
GEO Series GSE193078. Mus musculus. 64 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Characterization of sequence determinants of enhancer function using natural genetic variation [ChIP-seq]
GEO Series GSE193727. Mus musculus. 119 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
AARCHIVED - Data for Defining the function of disease variants with CRISPR editing and multimodal single cell sequencing: PTEN, FBXO11, HLA-DQB1
<p>Please refer to the more recent Zenodo record here: <a href="https://zenodo.org/records/15935857">https://zenodo.org/records/15935857</a>.</p>
Characterization of sequence determinants of enhancer function using natural genetic variation [ATAC-seq]
GEO Series GSE193420. Mus musculus. 51 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.