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228
datasets available to search
ShareScore release 0.9.0
Dataset results
228 results for “model therapy”
Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis
ClinicalTrials.gov study NCT06626984. IPD Sharing: NO. Countries: 0. Publications: 0.
Development and Validation of a Post-operative Risk Of Local Recurrence Model Integrating Serology and Evalution (PROMISE) in Local Advanced Rectal Cancer Receiving Neoadjuvant Therapy: a Multicenter
ClinicalTrials.gov study NCT07351708. IPD Sharing: NO. Countries: 0. Publications: 0.
Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model.
ClinicalTrials.gov study NCT06311916. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Dual AAV gene therapy in combination with rapamycin rescues muscle and liver impairment in a mouse model of GSDIII.
GEO Series GSE232166. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model
GEO Series GSE204795. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
AAV-CYP46A1 gene therapy in mouse models of Huntington’s disease
GEO Series GSE220224. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
GEO Series GSE124537. Mus musculus. 26 samples. Type: Expression profiling by array.
Gut microbiota dysbiosis affects intestinal sensitivity through epithelium-to-neuron signaling: novel insights from colon organoid-based model to improve visceral pain therapy
GEO Series GSE294757. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A phenotype-based model for rational selection of novel targeted therapies in treating aggressive breast cancer
GEO Series GSE18331. Homo sapiens. 14 samples. Type: Expression profiling by array.
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq]
GEO Series GSE240496. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy
GEO Series GSE205641. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Immunosuppressive crosstalk between tumour cells, myeloid cells and T cells in an anti-PD-1 plus anti-CTLA-4 therapy resistant mouse ccRCC model [RNA-seq]
GEO Series GSE259359. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A cell therapy to restore Trem2 function in a mouse model of Alzheimer's disease
GEO Series GSE235607. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Cancer therapy induced effects on lung organoids as suitable in vitro model [scRNA]
GEO Series GSE277088. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq2]
GEO Series GSE241936. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Long‐term combination therapy with metformin and oxymetholone in a Fanconi anemia mouse model
GEO Series GSE266448. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Intranasal therapy with miRNA-219 reduces viral load and encephalomyelitis in the TMEV model of multiple sclerosis
GEO Series GSE107091. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Recursive partitioning model-based analysis for survival of colorectal cancer patients with lung and liver oligometastases treated with stereotactic body radiation therapy"
<p>This record contains raw data related to article “Recursive partitioning model-based analysis for survival of colorectal cancer patients with lung and liver oligometastases treated with stereotactic body radiation therapy"</p> <p><strong>Introduction: </strong>Liver and lung are common sites of metastases from colorectal cancer (CRC). Stereotactic body radiation therapy (SBRT) represents a valid treatment, with high rates of local control (LC). In this study, we applied recursive partitioning model-based analysis (RPA) to define class risks for overall survival (OS) and progression free survival (PFS) in oligometastatic CRC patients.</p> <p><strong>Materials and methods: </strong>In this monocentric analysis, we included patients with lung or liver metastases. Patients were candidate to SBRT if a maximum of 5 metastases. End points of the present analysis were LC, PFS, and OS. The binary classification tree approach with RPA was applied to stratify the patients into risk groups based on OS and PFS.</p> <p><strong>Results: </strong>218 patients were treated with SBRT on 371 metastases. Majority of patients (56%) was treated on single lesion, followed by 2 (26.1%) and 3 lesions (14.7%). Median follow-up was 22.7 months. Rates of LC were 84.2% at 1 year and 73.8% at 3 years. Rates of PFS at 1 and 3 years were 42.2% and 14.9%, respectively. RPA identified 3 classes for PFS, according to age and number of metastases with 3-year PFS of 30.6%, 13.5% and 8.4%. Overall survival was 87.2% at 1 year, 51.9% at 3 years, and 36.8% at 5 years. RPA identified 3 nodes. Class 1 included patients with liver metastases (3-year OS 35.2%). Class 2 included patients with lung metastases and DFI ≤ 48 months (3-year OS 65%). Class 3 included patients with lung metastases and DFI > 48 months (3-year OS 73.5%).</p> <p><strong>Conclusions: </strong>Stereotactic body radiation therapy can be considered an effective treatment for the management of liver and lung metastases from CRC. With RPA, we identified prognostic risk class to define patients who could benefit the most from SBRT.</p>
Skeletal muscle derived stem cell implantation therapy in a rat model of erectile dysfunction
GEO Series GSE72834. Rattus norvegicus. 2 samples. Type: Expression profiling by array.
Rationalistic Modulation of Immune Mechanisms Synergizes the Anti-Tumor Effects of Targeted Radiation Therapy in Pre-clinical Models
GEO Series GSE294347. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.