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274
datasets available to search
ShareScore release 0.9.0
Dataset results
274 results for “phenotypic response”
Influenza H3N2 infection of the Collaborative Cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice (blood)
GEO Series GSE74073. Mus musculus. 50 samples. Type: Expression profiling by array.
Effects of endotoxin abundance in house dust mite on the molecular phenotype of inflammation and tissue response in mouse lung
GEO Series GSE116967. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations [xenograft]
GEO Series GSE311813. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Data from: The effects of genotype × phenotype interactions on transcriptional response to silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells
The airway epithelium is critical for maintaining innate and adaptive immune responses, and occupational exposures that disrupt its immune homeostasis may initiate and amplify airway inflammation. In our previous study, we demonstrated that silver nanoparticles (AgNP), which are engineered nanomaterials used in multiple applications but primarily in the manufacturing of many antimicrobial products, induce toxicity in organotypic cultures derived from murine tracheal epithelial cells (MTEC), and those differentiated toward a "Type 2 [T2]-Skewed" phenotype experienced an increased sensitivity to AgNP toxicity, suggesting that asthmatics could be a sensitive population to AgNP exposures in occupational settings. However, the mechanistic basis for this genotype × phenotype interaction (G×P) has yet to be defined. In the present study, we conducted transcriptional profiling using RNA-sequencing (RNA-seq) to predict the enrichment of specific canonical pathways and upstream transcriptional regulators to assist in defining a mechanistic basis for G×P effects on AgNP toxicity. Organotypic cultures were derived from MTEC across two genetically inbred mouse strains (A/J and C57BL/6J mice), two phenotypes ("Normal" and "T2-Skewed"), and one AgNP exposure (an acute 24 h exposure) to characterize G×P effects on transcriptional response to AgNP toxicity. The "T2-Skewed" phenotype was marked by increased pro-inflammatory T17 responses to AgNP toxicity, which are significant predictors of neutrophilic/difficult-to-control asthma and suggests that asthmatics could be a sensitive population to AgNP exposures in occupational settings. This study highlights the importance of considering G×P effects when identifying these sensitive populations, whose underlying genetics or diseases could directly modify their response to AgNP exposures.
Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
ClinicalTrials.gov study NCT01352559. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Genes, Intermediate Phenotypes and Response to Quetiapine RX
ClinicalTrials.gov study NCT01044914. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phenotyping Response to Spinal Cord Stimulation in Chronic Low Back Pain
ClinicalTrials.gov study NCT06310226. IPD Sharing: NO. Countries: 1. Publications: 0.
Deep, Multi-omics Phenotyping to Predict Response, Resistance and Recurrence to Adjuvant Atezolizumab Plus Bevacizumab in Resected Hepatocellular Carcinoma
ClinicalTrials.gov study NCT05516628. IPD Sharing: NO. Countries: 1. Publications: 0.
Memory Phenotype and PD-1 Inhibition Response in Oral Cancer
ClinicalTrials.gov study NCT03862066. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The RepEAT Study: Individual Differences in Postprandial Glucose Responses and the Relation With Diet and Phenotype
ClinicalTrials.gov study NCT05456815. IPD Sharing: NO. Countries: 1. Publications: 0.
Multiple Environmental Stressors Induce Complex Transcriptomic Responses Indicative of Phenotypic Outcomes in Western Fence Lizard [Exposure 2: food limitation x malaria infection]
GEO Series GSE116024. Sceloporus occidentalis. 33 samples. Type: Expression profiling by array.
Small Extracellular Vesicles from Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response [bulk RNA-seq]
GEO Series GSE286945. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: The effects of genotype × phenotype interactions on transcriptional response to silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells
Open the record for dataset details and reuse information.
Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1
GEO Series GSE312686. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Integrative phenotypic and genomic analyses reveal strain-dependent responses to acute ozone exposure and their associations with airway macrophage transcriptional activity [ATAC-seq]
GEO Series GSE174206. Mus musculus. 11 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade
GEO Series GSE139047. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Monocyte and Macrophage Transcriptional Phenotypes in Systemic Juvenile Idiopathic Arthritis Reveal TRIM8 as a Mediator of IFN-γ Hyper-responsiveness and Risk for Macrophage Activation Syndrome
GEO Series GSE147795. Homo sapiens. 242 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture
GEO Series GSE103773. Halomonas sp. HL48; Halomonas sp. HL58. 22 samples. Type: Expression profiling by high throughput sequencing.
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations [8 cancer cell lines]
GEO Series GSE283141. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
A sputum gene expression signature of six biomarkers identifies asthma inflammatory phenotype and steroid responsiveness
GEO Series GSE45111. Homo sapiens. 47 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.