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212
datasets available to search
ShareScore release 0.9.0
Dataset results
212 results for “thyroid carcinoma”
Circulating small extracellular vesicle-based miRNA classifier for follicular thyroid carcinoma: a multicenter diagnostics study
GEO Series GSE221088. Homo sapiens. 160 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Identification of long noncoding RNAs involved in clinicopathological features of papillary thyroid carcinoma complicated with Hashimoto's thyroiditis
GEO Series GSE192560. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by array; Expression profiling by array.
Prophylactic Selective Lateral Neck Dissection in Patients With Papillary Thyroid Carcinoma
ClinicalTrials.gov study NCT01103557. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Next Generation translatome Sequencing (Ribo-seq) of Papillary Thyroid Carcinoma tissue sample and adjacent normal tissue
GEO Series GSE212031. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Total transcriptome sequencing of papillary thyroid carcinoma samples
GEO Series GSE197443. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma
GEO Series GSE137698. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
A comparative analysis of tissue-based and liquid-based next-generation sequencing in patients with anaplastic thyroid carcinoma
GEO Series GSE281660. Homo sapiens. 41 samples. Type: Other.
Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma [ChIP-seq]
GEO Series GSE137696. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A two miRNA classifier differentiates follicular thyroid carcinomas from follicular thyroid adenomas
GEO Series GSE62054. Homo sapiens. 25 samples. Type: Expression profiling by array.
Gene array analysis of anaplastic thyroid carcinoma cell lines versus normal thyroid cell lines
GEO Series GSE85457. Homo sapiens. 7 samples. Type: Expression profiling by array.
Diagnostic Value and Clinical Significance of Potential BRAF-related Genes in Papillary Thyroid Carcinoma
GEO Series GSE309678. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Dataset associated with the journal publication "EXTRA-NUCLEAR TERT COUNTERACTS OXIDATIVE STRESS AND PROMOTES PROGRESSION IN PAPILLARY THYROID CARCINOMA"
<p>Abstract:</p> <p>The reactivation of TERT is associated with poor outcome in papillary thyroid cancer (PTC). Extra-telomeric functions of TERT were reported, with a protective role against oxidative stress (OS). The aim of the present study was to explore the extra-nuclear TERT localization in PTC and its role in cancer progression.</p> <p>TERT nuclear export under OS were analyzed in K1 PTC cell line. We investigated the role of different TERT localizations using specific TERT constructs that limit its localization to the nucleus or to the mitochondria. The effect of SRC kinase inhibitor PP2, which reduces TERT nuclear export, was investigated as well. Moreover, TERT localization was analyzed in 39 PTC tissues and correlated with the genetic profile and the level of OS, DNA damage and apoptosis in the tumors and with the clinical characteristics of the patients.</p> <p><a name="_Hlk150318531"></a>We demonstrated that TERT is exported from the nucleus in response to OS induced either from H2O2 or the BRAF inhibitor PLX4720. We proved that extra-nuclear TERT reduces mitochondrial OS and induces mitochondrial fragmentation. Moreover, limiting mitochondrial TERT localization reduced proliferation, migration, AKT phosphorylation and glycolysis and increased DNA damage and p21 expression. Finally, in PTC tissues the fraction of mitochondrial/nuclear TERT resulted inversely correlated with OS and p21 expression and associated with tumor persistence.</p> <p>In conclusion, our data indicate that extra-nuclear TERT is involved in reducing the effect of excessive OS, thus <a name="_Hlk150318490"></a>promoting cancer cell survival. Extra-nuclear TERT may thus represent a marker of cancer progression and a possible therapeutic target in PTC.</p> <p> </p> <p>This dataset of raw data cannot be made publicly available as it contains sensitive information, but may be made available to interested researchers on reasonable request at m.muzza@auxologico.it</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.