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12,871 results for “aging;”
Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates
<p>After middle age, in human bone, the resorption usually exceeds formation resulting in bone loss and increased risk of fractures in the aged population. Only few in vivo models in higher vertebrates are available for pathogenic and therapeutic studies about bone aging. Among these, male Danio rerio (zebrafish) can be successfully used as low vertebrate model to study degenerative alterations that affect the skeleton during aging, reducing the role of sex hormones.In this paper, we investigated the early bone aging mechanisms in male zebrafish (3, 6, 9 months old) scales evaluating the physiological changes and the effects of prednisolone, a pro-osteoporotic drug.The results evidentiated an age-dependent reduction of the mineralization rate in the fish scales, as highlighted by growing circle measurements. Indeed, the osteoblastic ALP activity at the matrix deposition site was found progressively downregulated.The higher TRAP activity was found in 63% of 9-month-old fish scales associated with resorption lacunae along the scale border. Gene expression analysis evidentiated that an increase of the tnfrsf1b (homolog of human rank) in aging scales may be responsible for resorption stimulation.Interestingly, prednisolone inhibited the physiological growth of the scale and induced in aged scales a more significant bone resorption compared with untreated fish (3.8% vs 1.02%). Bone markers analysis shown a significant reduction of ALP/TRAP ratio due to a prednisolone-dependent stimulation of tnfsf11 (homolog of human rankl) in scales of older fish.The results evidentiated for the first time the presence of a senile male osteoporosis in lower vertebrate. This new model could be helpful to identify the early mechanisms of bone aging and new therapeutic strategies to prevent age-related bone alterations in humans.</p>
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
<p>Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain-of-activity mouse model presents with a pre-mature aging-like phenotype and with decreased lifespan. These data suggest a causal connection between elevated activity of Cdc42, aging and reduced lifespan. Here, we demonstrate that systemic treatment of aged (75-week old) female C57BL/6 mice with a Cdc42 activity specific inhibitor (CASIN) for 4 consecutive days significantly extends average and maximum lifespan. Moreover, aged CASIN-treated animals displayed a youthful level of the aging-associated cytokines IL-1b, IL-1a and INFg in serum and a significantly younger epigenetic clock as based on DNA methylation levels in blood cells. Overall, our data show that systemic administration of CASIN to reduce Cdc42 activity in aged mice extends murine lifespan.</p>
Dynamic effects of insect herbivory and climate on tundra shrub growth: roles of browsing and ramet age
1. To predict shrub responses under climate change in tundra, we need to understand how thermal conditions and herbivory contribute to growth. We hypothesise that shrub growth increases with thermal conditions and precipitation, but that this increase is counteracted by insect herbivory, and that these climate-insect herbivory relationships are modified by both browsing and plant age. 2. We use empirical dynamic modelling (EDM) to analyse a 20-year time series on willow (Salix phylicifolia) shoot growth, growing degree days, summer precipitation and herbivory from an experiment at forest-tundra ecotone. The experiment includes manipulations of avian and mammal browsing (fences) and ramet age (pruning to rejuvenate willows). 3. Negative effects of insect herbivory on willow shoot growth were intensified during warmer years, whereas increasing precipitation led to reduced effects. Moreover, the effect of insect herbivores on shoot growth varied with ramet age and vertebrate browsing: Younger ramets generally experienced less negative insect herbivore effects, whereas Ptarmigan browsing was associated with more positive temperature effect on shoot growth, and reindeer browsing with more negative effects of insect herbivory and precipitation. 4. Synthesis. Our findings show that the negative effects of insect herbivory on shoot growth likely intensify under warmer thermal conditions, but that increasing precipitation can counteract these effects. Moreover, changing thermal conditions, precipitation and vertebrate browsers all have predictable, albeit complex and nonlinear, effects on shrub growth, highlighting the importance of long-term experimental data and flexible analytical methods such as EDM for characterizing climate and community interactions in artic systems.
Asymmetric contextual effects in age perception dataset
<p>Perception is context dependent. For example, the perceived orientation of a bar changes depending on the presence of oriented bars around it. Contextual effects have also been demonstrated for more complex judgements, such as facial attractiveness or expression, although it remains unclear how these contextual facial effects depend on the types of faces surrounding the target face.To examine this, we measured the perceived age (a quantifiable measure) of a target face in the presence of differently aged faces in the surround. Using a unique database of standardized passport photos, participants were asked to estimate the age of a target face which was viewed either on its own or surrounded by two different identity flanker faces. The flanker faces were either both younger or both older than the target face, with different age offsets between flankers and targets of ±5, ±10, ±15, ±20 years. We find that when a target face is surrounded by younger faces, it systematically appears younger than when viewed on its own, and when it is surrounded by older faces, it systematically appears older than when viewed on its own. Surprisingly, we find that the magnitude of the flanker effects on perceived age of the target is asymmetric with younger flankers having a greater influence than older flankers, a result that may reflect the participants' own-age bias, since all participants were young. This result holds irrespective of gender or race of the faces and is consistent with averaging.</p>
Song parameters, repertoire size and song sharing within and across age classes in the saffron finch
<p>Birds sing mostly to attract partners or to defend territories or resources. In relation to the first function, song can vary with age if older experienced males signal their quality through their vocal output. Regarding the second function, song can also vary with age if singing behavior helps mediate social interactions through repertoire sharing with neighbors. Here, we investigate whether song parameters change with age, and in which direction, in saffron finches Sicalis flaveola pelzelni, obligate secondary cavity nesters which produce elaborate melodious songs and show delayed plumage maturation. Cross-sectional comparisons revealed that second year (SY) males sing shorter syllables, and shorter and less versatile songs than older after second year males (ASY), as expected if the latter are more experienced singers. Longitudinal comparisons, which better depict age-related changes, showed that as birds age one year, song length and repertoire size do not change significantly, syllable duration shortens and, as expected for experienced singers, song versatility increases. Correlations between repertoire distance and nesting distance suggest that both SY and ASY males might be adjusting their repertoires to those of ASY neighbors; the former pattern conforms to the expectations if young birds try to emulate the songs of more experienced birds, while the latter is expected if song sharing helps de-escalating antagonistic social interactions amongst males. This research, which provides the first description of song parameters in young second year saffron finches, expands our knowledge of song variation across age classes in songbirds.</p>
The datasets for the paper "The long-lived and recent seismicity at the lunar Orientale basin: Evidence from morphology and formation ages of boulder avalanches, tectonics and seismic ground motion" JGR: Planets (e2020JE006553)
<p>The datasets contain supporting files for the paper:</p> <p>Mohanty, R., Kumar, P.S., Raghukanth, S.T.G., & Lakshmi, K.J.P., (2020). The long-lived and recent seismicity at the lunar Orientale basin: Evidence from morphology and formation ages of boulder avalanches, tectonics and seismic ground motion, JGR: Planets, e2020JE006553.</p>
Number of bovine animals tested by age group, reporting country and target group, 2019
<p>The tables contain the number of bovine animals tested by age group, reporting country and target group, 2019</p>
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
<p>Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is lacking a clinically effective treatment. Using the model of naturally aging mice and rats, we show direct evidence of increased proton leak in the aged heart mitochondria. Moreover, our data suggested ANT1 as the most likely site of mediating increased mitochondrial proton permeability in old cardiomyocytes. Most importantly, the tetra-peptide SS-31 prevents age-related excess proton entry, decreases the mitochondrial flash activity and mitochondrial permeability transition pore opening, rejuvenates mitochondrial function by direct association with ANT1 and the mitochondrial ATP synthasome, and leads to substantial reversal of diastolic dysfunction. Our results uncover the excessive proton leak as a novel mechanism of age-related cardiac dysfunction and elucidate how SS-31 is able to reverse this clinically important complication of cardiac aging.</p>
The Age-dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent SUPPLEMENTAL DATA
<p>Supplemental tables 1 and 2.</p>
The Immp2l mutation causes ovarian aging through ROS-wnt/β-catenin-estrogen (cyp19a1) pathway: preventive effect of melatonin
<p>Mitochondria play important roles in ovarian follicle development. Mitochondrial dysfunction, including mitochondrial gene deficiency, impairs the ovarian development. Here, we explored the role and mechanism of mitochondrial inner membrane gene <i>Immp2l</i> in ovarian follicle growth and development. Our results revealed that the female Immp2l<sup>-/-</sup> mice were infertile, while the Immp2l<sup>+/- </sup>mice were normal. Body and ovarian weights were reduced in the female Immp2l<sup>-/- </sup>mice, ovarian follicle growth and development were stunted in the secondary follicle stage. Although a few ovarian follicles were ovulated, the oocytes were not fertilized due to mitochondrial dysfunction. Increased oxidative stress, decreased estrogen levels, and altered genes expression of Wnt/β-catenin and steroid hormone synthesis pathways were observed in 28-day-old Immp2l<sup>-/-</sup> mice. The Immp2l mutation accelerated ovarian aging process, as no ovarian follicles were detected in age of 5 months in Immp2l<sup>-/- </sup>mice. All the aforementioned changes in the Immp2l<sup>-/- </sup>mice were reversed by administration of antioxidant melatonin to the Immp2l<sup>-/-</sup> mice. Furthermore, our in vitro study using Immp2l knockdown granulosa cells confirmed that the Immp2l downregulation induced granulosa cell aging by enhancing ROS levels, suppressing <i>Wnt16</i>, increasing β-catenin and decreasing steroid hormone synthesis gene <i>cyp19a1</i> and estrogen levels, accompanied by an increase in the aging phenotype of granulosa cells. Melatonin treatment delayed granulosa cell aging progression. Taken together, Immp2l causes ovarian aging through the ROS-Wnt/β-catenin-estrogen (cyp19a1) pathway, which can be reversed by melatonin treatment.Mitochondria play important roles in ovarian follicle development. Mitochondrial dysfunction, including mitochondrial gene deficiency, impairs the ovarian development. Here, we explored the role and mechanism of mitochondrial inner membrane gene <i>Immp2l</i> in ovarian follicle growth and development. Our results revealed that the female Immp2l<sup>-/-</sup> mice were infertile, while the Immp2l<sup>+/- </sup>mice were normal. Body and ovarian weights were reduced in the female Immp2l<sup>-/- </sup>mice, ovarian follicle growth and development were stunted in the secondary follicle stage. Although a few ovarian follicles were ovulated, the oocytes were not fertilized due to mitochondrial dysfunction. Increased oxidative stress, decreased estrogen levels, and altered genes expression of Wnt/β-catenin and steroid hormone synthesis pathways were observed in 28-day-old Immp2l<sup>-/-</sup> mice. The Immp2l mutation accelerated ovarian aging process, as no ovarian follicles were detected in age of 5 months in Immp2l<sup>-/- </sup>mice. All the aforementioned changes in the Immp2l<sup>-/- </sup>mice were reversed by administration of antioxidant melatonin to the Immp2l<sup>-/-</sup> mice. Furthermore, our in vitro study using Immp2l knockdown granulosa cells confirmed that the Immp2l downregulation induced granulosa cell aging by enhancing ROS levels, suppressing <i>Wnt16</i>, increasing β-catenin and decreasing steroid hormone synthesis gene <i>cyp19a1</i> and estrogen levels, accompanied by an increase in the aging phenotype of granulosa cells. Melatonin treatment delayed granulosa cell aging progression. Taken together, Immp2l causes ovarian aging through the ROS-Wnt/β-catenin-estrogen (cyp19a1) pathway, which can be reversed by melatonin treatment.</p>
Cosmogenic Ages from Alluvial Fans offset by Central Walker Lane Faults
<p>Here are a series of cosmogenic 10Be and 36Cl ages and metadata for samples related to a faulting study southeast of Reno, NV, USA. Both 10Be and 36Cl concentrations were measured at the PRIME lab at Purdue. All 10Be samples were processed in the Geochronology Laboratories at the University of Cincinnati. The 36Cl samples were processed and analyzed at the PRIME lab. Boulder sampling focused on the largest boulders (~50–150-cm-diameter) from alluvial fan surfaces. Approximately 500 g samples were taken from the upper 2–5 cm of each of these boulders. 10Be concentrations and laboratory data are listed in these tables. The 10Be boulder exposure ages were calculated using the Cosmic Ray Exposure Program (CREp). The calculator requires input describing the geographic coordinates and elevation of the samples, local shielding of the sample, density of the sample, and estimation of the boulder erosion rates resulting from processes such as boulder grussification and spalling. The age estimates are also dependent on the assumption of particular scaling models designed to estimate the long-term production rate of cosmogenic 10Be. The 10Be ages use a production rate of 4.05 ± 0.30 at/g SiO2/yr determined at Twin Lakes, which is located at a higher elevation than the fan surfaces here, but is within 100 km of all study sites, the ERA40 atmosphere model, the Lifton-VDM2016 geomagnetic database, and the LSD scaling scheme.The 36Cl boulder ages are calculated using the CRONUS calculator for 36Cl.</p>
Age-related reproductive performance of the Adélie Penguin, a long-lived seabird exhibiting similar outcomes regardless of individual life-history strategy
<p>1. Age-related variation in reproductive performance in long-lived iteroparous vertebrate species is common, with performance being influenced by within-individual processes, such as improvement and senescence, in combination with among-individual processes, such as selective appearance and disappearance. Few studies of age-related reproductive performance have compared the role of these drivers within a metapopulation, subject to varying degrees of resource competition.</p> <p>2. We accounted for within- and among-individuals changes among known-aged Adélie penguins (Pygoscelis adeliae) during 17 years (1997 to 2013), at three clustered colonies of disparate size, to understand patterns in age-related reproductive success during early and late adulthood.</p> <p>3. Age at first reproduction (AFR) was lowest, and number of breeding attempts highest, at the largest colony. Regardless of AFR, success improved with early post-recruitment experience. For both oldest and youngest recruitment groups, peak performance occurred at the end of their reproductive lifespan indicating a possible cost of reproduction. Intermediate recruitment groups reached peak performance in their mid-reproductive lifespan and with intermediate breeding experience, before decreasing. Breeding success was lowest for the initial breeding attempt regardless of AFR, but we observed subsequent variation relative to recruitment age. Gaining experience by delaying recruitment positively influenced reproductive performance early in the reproductive lifespan, and was most evident for the youngest breeders. Oldest recruits had the highest initial and peak breeding success. Differences in AFR resulted in tradeoffs in reproductive lifespan or timing of senescence but not in the overall number of breeding attempts.</p> <p>4. Patterns differed as a function of colony size, and thus competition for resources. Early life improvement in performance at the larger colonies was primarily due to within-individual factors and at the largest colony, AFR. Regardless of colony size late-life performance was positively related to the age at last reproduction, indicating selective disappearance of lower performing individuals.</p> <p>5. These results highlight that different life-history strategies were equally successful, indicating that individuals can overcome potential tradeoffs associated with early- and late-life performance. These results have important implications for understanding the evolution of life-history strategies responsible for driving population change.</p>
Social isolation induces hyperactivity and exploration in aged female mice - Raw Data
<p>Raw data for the publication Social isolation induces hyperactivity and exploration in aged female mice accepted in PLOS One. Data is public for transparency and future utilization.</p>
Effect of long-term aging on graphene oxide: structure and thermal decomposition
<p>FTIR, XRD, Raman, AFM, XPS were used to characterize graphene oxide aged for 2 years. The results showed that after aging, the C/O ratio of graphene oxide increased from 1.96 to 2.76, but the type of oxygen-containing functional groups did not change. In addition to oxygen-containing functional groups, the content of -CH3, -CH2- and physically adsorbed water also decreased. The change in the structure is manifested by the reduction of the average interlayer distance from 1.320 nm to 1.134 nm. Moreover, ID/IG increased from 0.95 to 1.03, indicating that the defect density in the carbon skeleton increased after aging. The thermal decomposition process of graphene oxide and its decomposition products were analyzed by thermogravimetric combined with Infrared spectroscopy. When the temperature exceeds 60°C, the infrared signal of CO2 produced by the decomposition of graphene oxide can be detected. After aging, the decomposition peak temperature of graphene oxide decreased from 216 to 195°C. The amount of CO2 produced in the decomposition products is almost unchanged, while the amount of CO and H2O produced decreases, and the amount of SO2 produced decreases significantly. The OH radicals and heat accumulated during the decomposition process may in turn accelerate the decomposition rate, leading to a thermal runaway process at 216°C.</p>
Ice-age persistence and genetic isolation of the disjunct distribution of larch in Alaska
<p class="CxSpFirst"><i>Larix laricina</i> (eastern larch, tamarack) is a transcontinental North American conifer with a prominent disjunction in the Yukon isolating the Alaskan distribution from the rest of its range. We investigate whether <i>in situ</i> persistence during the Last Glacial Maximum (LGM) or long-distance postglacial migration from south of the ice sheets resulted in the modern-day Alaskan distribution. We analyzed variation in three chloroplast DNA regions of 840 trees from a total of 69 populations (24 new sampling sites situated on both sides of the Yukon range disjunction pooled with 45 populations from a published source) and conducted ensemble species distribution modeling (SDM) throughout Canada and USA to hindcast the potential range of <i>Larix laricina</i> during the LGM. We uncovered the genetic signature of a long-term isolation of larch populations in Alaska, identifying three endemic chlorotypes and low levels of genetic diversity. Range-wide analysis across North America revealed the presence of a distinct Alaskan lineage. Postglacial gene flow across the Yukon divide was unidirectional, from Alaska toward previously glaciated Canadian regions, and with no evidence of immigration into Alaska. Hindcast SDM indicates one of broadest areas of past climate suitability for <i>Larix laricina</i> existed in central Alaska, suggesting possible <i>in situ</i> persistence of larch in Alaska during the LGM. Our results provide the first unambiguous evidence for the long-term isolation of <i>Larix laricina</i> in Alaska that extends beyond the last glacial period and into the present interglacial period. The lack of gene flow into Alaska along with the overall probability of larch occurrence in Alaska being currently lower than during the LGM, suggest that modern-day Alaskan larch populations are isolated climate relicts of broader glacial distributions, and so are particularly vulnerable to current warming trends.</p>
Helpers compensate for age-related declines in parental care and offspring survival in a cooperatively breeding bird
<p>Offspring from elderly parents often have lower survival due to parental senescence. In cooperatively breeding species, where offspring care is shared between breeders and helpers, the alloparental care provided by helpers is predicted to mitigate the impact of parental senescence on offspring provisioning and, subsequently, offspring survival. We test this prediction using data from a long-term study on cooperatively breeding Seychelles warblers (<i>Acrocephalus sechellensis</i>). We find that the nestling-provisioning rate of female breeders declines with their age. Further, the total brood provisioning rate and the first-year survival probability of offspring decline progressively with age of the female breeder, but these declines are mitigated when helpers are present. This effect does not arise because individual helpers provide more care in response to the lower provisioning of older dominant females, but because older female breeders have recruited more helpers, thereby receiving more overall care for their brood. We do not find such effects for male breeders. These results indicate that alloparental care can alleviate the fitness costs of senescence for breeders, which suggests an interplay between age and cooperative breeding.</p>
Clinicians' opinions on recommending aspirin to prevent colorectal cancer to Australians aged 50 to 70 years: A qualitative study
<span>Objectives</span> <p>Australian guidelines recommend all 50 to 70-year-olds without existing contraindications consider taking low-dose aspirin (100 mg – 300 mg per day) for at least 2.5 years to reduce their risk of developing colorectal cancer.</p> <p>We aimed to explore clinicians', practices, knowledge, opinions, and barriers and facilitators to the implementation of these new guidelines.</p> <span>Methods</span> <p>Semi-structured interviews were conducted with clinicians to whom the new guidelines may be applicable (familial cancer clinic staff (geneticists, oncologists and genetic counsellors), gastroenterologists, pharmacists, and general practitioners (GPs)).</p> <p>The Consolidated Framework for Implementation Research (CFIR) underpinned the development of the interview guide. Coding was inductive and themes were developed through consensus between the authors.</p> <p>Emerging themes were mapped onto the CFIR domains: characteristics of the intervention, outer setting, inner setting, individual characteristics and process.</p> <span>Results </span> <p>Sixty-four interviews were completed between March and October 2019. Aspirin was viewed as a safe and cheap option for cancer prevention. GPs were considered by all clinicians as the most important health professionals for implementation of the guidelines. Cancer Council Australia, as a trusted organisation, was an important facilitator to guideline adoption. Uncertainty about aspirin dosage and perceived strength of the evidence, the precise wording of the recommendation, previous changes to guidelines about aspirin, and conflicting findings from trials in older populations were barriers to implementation.</p> <span>Conclusion</span> <p>Widespread adoption of these new guidelines could be an important strategy to reduce the incidence of bowel cancer, but this will require more active implementation strategies focused on primary care and the wider community.</p>
Data from: The effects of aging on neuropil structure in mouse somatosensory cortex—A 3D electron microscopy analysis of layer 1
This study has used dense reconstructions from serial EM images to compare the neuropil ultrastructure and connectivity of aged and adult mice. The analysis used models of axons, dendrites, and their synaptic connections, reconstructed from volumes of neuropil imaged in layer 1 of the somatosensory cortex. This shows the changes to neuropil structure that accompany a general loss of synapses in a well-defined brain region. The loss of excitatory synapses was balanced by an increase in their size such that the total amount of synaptic surface, per unit length of axon, and per unit volume of neuropil, stayed the same. There was also a greater reduction of inhibitory synapses than excitatory, particularly those found on dendritic spines, resulting in an increase in the excitatory/inhibitory balance. The close correlations, that exist in young and adult neurons, between spine volume, bouton volume, synaptic size, and docked vesicle numbers are all preserved during aging. These comparisons display features that indicate a reduced plasticity of cortical circuits, with fewer, more transient, connections, but nevertheless an enhancement of the remaining connectivity that compensates for a generalized synapse loss.
Data from: The effects of age, sex, and habitat on body size and shape of the blackstripe topminnow, Fundulus notatus
Lake and stream habitats pose a variety of challenges to fishes due to differences in variables such as water velocity, habitat structure, prey community, and predator community. These differences can cause divergent selection on body size and/or shape. Here, we measured sex, age, length, and eight different morphological traits of the blackstripe topminnow, Fundulus notatus, from 19 lake and stream populations across four river drainages in central Illinois. Our goal was to determine whether size and shape differed consistently between lake and stream habitats across drainages. We also considered the effects of age and sex as they may affect size and morphology. We found large differences in body size of age 1 topminnows where stream fish were generally larger than lake fish. Body shape mainly varied as a function of sex. Adult male topminnows had larger morphological traits (with the exception of body width) than females, in particular longer dorsal and anal base lengths. Subtle effects of habitat were present. Stream fish had a longer dorsal fin base than lake fish. These phenotypic patterns may be the result of genetic and/or environmental variation. As these lakes are human-made, the observed differences, if genetic, would have had to occur relatively rapidly (within about 100 years).
Data from: Better stay together: pair bond duration increases individual fitness independent of age-related variation
Prolonged pair bonds have the potential to improve reproductive performance of socially monogamous animals by increasing pair familiarity and enhancing coordination and cooperation between pair members. However, this has proved very difficult to test robustly because of important confounds such as age and reproductive experience. Here, we address limitations of previous studies and provide a rigorous test of the mate familiarity effect in the socially monogamous blue-footed booby, Sula nebouxii, a long-lived marine bird with a high divorce rate. Taking advantage of a natural disassociation between age and pair bond duration in this species, and applying a novel analytical approach to a 24 year database, we found that those pairs which have been together for longer establish their clutches five weeks earlier in the season, hatch more of their eggs and produce 35% more fledglings, regardless of age and reproductive experience. Our results demonstrate that pair bond duration increases individual fitness and further suggest that synergistic effects between a male and female's behaviour are likely to be involved in generating a mate familiarity effect. These findings help to explain the age- and experience-independent benefits of remating and their role in life-history evolution.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.