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Figure 3 from: Strus O, Polovko N, Yezerska O (2019) Justification of technological parameters of the cream production with sapropel extract. Pharmacia 66(1): 19-25. https://doi.org/10.3897/pharmacia.66.e35022
Figure 3 Dependence of a cream structural viscosity from stirring speed.
The role of hemostatic agents following dental extractions: a systematic review and meta-analysis
<p class="MsoNormal"><span><strong>Objective: </strong>This study critically evaluated the role of hemostatic agents following dental extractions, and the benefits they add over conventional hemostatic measures.</span></p> <p class="MsoNormal"><span><strong>Materials and methods: </strong>a literature search was conducted, including publications that fulfilled the criteria <span>developed based on the PICOS guidelines; </span><span>Population: <span>patients who receive simple or surgical tooth extractions</span>, </span><span>Intervention: the use of hemostatic agents following dental extraction, </span><span>Control: </span><span>any type of conventional hemostatic measures (i.e. suture, gauze pressure)</span><span>, </span><span>Outcome: </span><span>time to achieve hemostasis following tooth removal, postoperative pain, swelling, or bleeding events, </span><span>and Study design: randomized/controlled clinical trials.</span></span></p> <p class="MsoNormal"><span><strong>Results:</strong> Twenty-eight articles met the inclusion criteria, and 24 were meta-analyzed. Several types of hemostatic agents were used, namely <span>tissue adhesives made from cyanoacrylate or fibrin, tranexamic acid, hemocoagulase</span>, <span>collagen membrane</span>, <span>HemCon dental dressing, epsilon aminocaproic acid</span>, <span>Surgicel</span>, <span>sponges or plugs composed of gelatin</span>, <span>oxidized cellulose</span>, <span>and fibrin</span>. <span>Newer hemostatic agents were also applied, such as Ankaferd blood stopper,</span> <span>and feracrylum</span>. Hemostatic agents demonstrated significantly shorter time to achieve hemostasis and fewer bleeding events in patients on antithrombotic drugs or with bleeding disorders<span> (WMD= -2.12, 95% CI -2.63 to -1.61, P < 0.00001, and RR </span><span>0.61, 95% CI 0.43 to 0.86; P= 0.005, respectively). Furthermore, the use of these agents resulted in significantly less postoperative pain following 3<sup>rd</sup> molar surgery in healthy patients (</span><span>WMD= -</span>0.33<span>, 95% CI </span>-0.65 to -0.02<span>, P = 0.04). Conversely, they did not have any effect on postoperative swelling (WMD= </span>-0.11<span>, 95% CI </span>-0.31 to 0.08<span>, </span>P = 0.26<span>). The time needed to finish the surgical procedure when hemostatic agents were used was shorter but with no significant difference </span>(MD= -78.93, 95% CI -187.35 to 29.49, P = 0.15).</span></p> <p class="MsoNormal"><span><strong>Conclusion: </strong>Included studies differ in their methods of reporting bleeding, pain, and swelling. Thus, the results of this article should be confirmed in future research. Within these limitations, it is concluded that hemostatic agents lead to faster hemostasis and fewer postoperative bleeding incidences, compared to conventional hemostatic measures. Their use is highly recommended following dental extractions in patients on antithrombotic drugs or with bleeding disorders, who are likely to develop postoperative hemorrhage events.</span></p>
Microscopy and track data for extraction of accurate cytoskeletal actin velocity distributions
<p>This data accompanies the paper <strong>Extraction of accurate cytoskeletal actin velocity distributions from noisy measurements</strong> by C M Miller, E Korkmazhan, and A R Dunn.</p> <p>The data include actin speckle microscopy videos and corresponding track files containing coordinates and other information from tracked speckles. These data were collected in both human foreskin fibroblasts (HFFs) and human umbilical vein endothelial cells (HUVECs). Each data "set" contains one group of fixed cells, and one or more groups of live cells. </p> <p>Further information about the data structure is supplied in the README doc, and further experimental detail in the accompanying paper: https://doi.org/10.1101/2020.08.13.247304 </p>
Figure 2 from: Camacho AI, Dorda BA, Chillón BS, Rey I (2017) The collection of Bathynellacea specimens of MNCN (CSIC) Madrid: microscope slices and DNA extract. ZooKeys 678: 31-63. https://doi.org/10.3897/zookeys.678.11543
Figure 2 - Bathynellacea holotypes by families and continents in the MNCN collections.
Figure 3 from: Camacho AI, Dorda BA, Chillón BS, Rey I (2017) The collection of Bathynellacea specimens of MNCN (CSIC) Madrid: microscope slices and DNA extract. ZooKeys 678: 31-63. https://doi.org/10.3897/zookeys.678.11543
Figure 3 - Bathynellacea genera by families in the MNCN collections versus world.
Figure 13 from: Camacho AI, Dorda BA, Chillón BS, Rey I (2017) The collection of Bathynellacea specimens of MNCN (CSIC) Madrid: microscope slices and DNA extract. ZooKeys 678: 31-63. https://doi.org/10.3897/zookeys.678.11543
Figure 13 - Number of records of Bathynellacea from Europe by countries in the MNCN collections.
Figure 12 from: Camacho AI, Dorda BA, Chillón BS, Rey I (2017) The collection of Bathynellacea specimens of MNCN (CSIC) Madrid: microscope slices and DNA extract. ZooKeys 678: 31-63. https://doi.org/10.3897/zookeys.678.11543
Figure 12 - Number of records of Bathynellacea by continents in the MNCN collections.
Figure 10 from: Camacho AI, Dorda BA, Chillón BS, Rey I (2017) The collection of Bathynellacea specimens of MNCN (CSIC) Madrid: microscope slices and DNA extract. ZooKeys 678: 31-63. https://doi.org/10.3897/zookeys.678.11543
Figure 10 - Number of species of Bathynellacea by continents and families in the MNCN collections.
Figure 1 from: Camacho AI, Dorda BA, Chillón BS, Rey I (2017) The collection of Bathynellacea specimens of MNCN (CSIC) Madrid: microscope slices and DNA extract. ZooKeys 678: 31-63. https://doi.org/10.3897/zookeys.678.11543
Figure 1 - Familiy records in the MNCN collections.
Extracting Regulatory Chromatin Footprint from Cell-Free DNA
<p>Cell-free DNA (cfDNA) has emerged as a pivotal player in precision medicine, revolutionizing the diagnostic and therapeutic landscape. While its clinical applications have significantly increased in recent years, current cfDNA assays have limited ability to identify the active transcriptional programs that govern complex disease phenotypes and capture the heterogeneity of the disease. To address these limitations, we have developed a non-invasive platform to enrich and examine the active chromatin fragments (cfDNAac) in peripheral blood. The deconvolution of the cfDNAac signal from traditional nucleosomal chromatin fragments (cfDNAnuc) yields a catalog of features linking these circulating chromatin signals in blood to specific regulatory elements across the genome, including enhancers, promoters, and highly transcribed genes, mirroring the epigenetic data from the ENCODE project. Notably, these cfDNAac counts correlate strongly with RNA polymerase II activity and exhibit distinct expression patterns for known circadian genes. Additionally, cfDNAac signals across gene bodies and promoters show strong correlations with whole blood gene expression levels defined by GTEx. This study illustrates the utility of cfDNAac analysis for investigating epigenomics and gene expression, underscoring its potential for a wide range of clinical applications in precision medicine.</p>
Policosanol extraction patents in six extraction routes from IP Business Intelligence of Orbit seekers (version 1.9.8)®: World and Ibero-American countries (CSV Format).
<p>These results include tables of contents in CSV format of patents, corresponding to the substance Policosanol and its six main extraction methods, in the world and in Ibero-American countries, prospected from Advanced Search and IP Business Intelligence of Orbit seekers (version 1.9.8)<sup>® </sup>(Orbit, 2013, 2015; Orbit Intelligence, 2021, 2022; Winson, 2013).</p> <p>No results were found for the Ibero-American countries, in technological route 5 - "Molecular Distillation", until October 1, 2024, reason for the absence of their respective files in PDF and CSV.</p> <p>The prospecting reports contain the following information:</p> <ol> <li>Priority numbers</li> <li>Application number</li> <li>Publication numbers</li> <li>Family numbers</li> <li>Priority dates</li> <li>Application dates</li> <li>Publication dates</li> <li>Grant date</li> <li>Expected expiry dates</li> <li>Titles</li> <li>Abstracts</li> <li>Assignees</li> <li>Inventors</li> <li>Representatives</li> <li>Key content</li> <li>Technical concepts</li> <li>Images</li> <li>Claims</li> <li>Description</li> <li>Keywords in context</li> <li>Technology domains</li> <li>Cooperative classification</li> <li>International classification</li> <li>US patent classification</li> <li>Japanese classifications</li> <li>Citing patents (forward citations)</li> <li>Citing patents - Raw information</li> <li>Cited patents (backward citations)</li> <li>Cited patents - Raw information</li> <li>Cited non-patent literature</li> <li>Legal status</li> <li>Legal actions</li> <li>Designated states</li> <li>Protected authorities</li> <li>Farliest countries</li> <li>Assignee country</li> <li>Representative country</li> <li>Inventor country</li> <li>Cited patents (backward citations) - Counts</li> <li>Citing patents (forward citations) - Counts</li> <li>Independent claims - Counts</li> <li>Dependent claims - Counts</li> <li>All claims - Counts</li> <li>Assignees - Counts</li> <li>Inventors - Counts</li> <li>Age - Counts</li> <li>Words in document - Questel semantic count</li> <li>Words in abstract - Questel semantic count</li> <li>Words in description - Questel semantic count</li> <li>WO and EP designated states - Counts</li> <li>Drawings - Counts</li> <li>US specific - Counts</li> <li>Licensing agreements - Counts</li> <li>Number of figures</li> <li>WO parent</li> <li>Number of priorities</li> <li>Licensing interest names</li> <li>Security interest names</li> <li>Referenced drug names</li> <li>WO parent</li> <li>EP parent</li> <li>Filing notes</li> <li>Filing details</li> <li>Filing language</li> <li>Litigation</li> <li>Standards</li> <li>Licence ID</li> </ol> <p>The original format of the report generated by the database was preserved.</p> <p>In order to manage the query according to specific or joint interests, the PDF files are presented separately and also gathered in a single document (with 12,200 pages). This aggregated file is organized with the results of the world appearing in first place and those of the Ibero-American countries next, both obeying the numbering order of the prospected routes, separated by the respective summaries of contents.</p>
Databases Merged of "Cross Meta-Analysis on Policosanol Extraction": World and Ibero-American Countries
<p>These database derives from the processes of standardization, merge and removing duplication of results found in the Scopus Elsevier and Web of Science bases, in CSV format to be used with software suitable for replicating the results, new statistical, bibliometric, semantic and other treatments.</p> <p> </p> <p>Database1 (World): (Search No. - Route): 01 – PC in General</p> <p>Database3 (World): (Search No. - Route): 03 – Saponification extraction</p> <p>Database4 (World): (Search No. - Route): 04 - Solvent extraction</p> <p>Database5 (World): (Search No. - Route): 05 - Molecular distillation extraction</p> <p>Database6 (World): (Search No. - Route): 06 – Transesterification extraction</p> <p>Database7 (World): (Search No. - Route): 07 - Supercritical carbon dioxide extraction</p> <p>Database8 (World): (Search No. - Route): 08 - Ultrasonic-assisted extraction</p> <p>...</p> <p>Database1 - Ibero-American: (Search No. - Route): 01 – PC in General</p> <p>Database3 - Ibero-American: (Search No. - Route): 03 – Saponification extraction</p> <p>Database4 - Ibero-American: (Search No. - Route): 04 - Solvent extraction</p> <p>No data - Database5 - Ibero-American: (Search No. - Route): 05 - Molecular distillation extraction </p> <p>No data - Database6 - Ibero-American: (Search No. - Route): 06 – Transesterification extraction</p> <p>Database7 - Ibero-American: (Search No. - Route): 07 - Supercritical carbon dioxide extraction</p> <p>Database8 - Ibero-American: (Search No. - Route): 08 - Ultrasonic-assisted extraction</p>
Figure 1 in Anti-dermatophyte activity of the aqueous extracts of Thai medicinal plants
Figure 1. Ethanolic plant extracts in dimethyl sulfoxide solvent.
Consistent differences in tissue oxygen levels across 15 insect species reflect a balance between oxygen supply and demand and highlight a hitherto unknown adaptation for extracting sufficient oxygen from water
<p><span>Animals, including insects, need oxygen for aerobic respiration and eventually asphyxiate without it. Aerobic respiration, however, produces reactive oxygen species (ROS), which contribute to dysfunction and aging. Animals appear to balance risks of asphyxiation and ROS by regulating internal oxygen to low but sufficient levels. How much do levels vary among species, and how does variation depend on environment and life history? We predicted that lower internal oxygen levels occur in insects with either limited access to environmental oxygen (i.e., insects dependent on aquatic respiration, where low internal levels facilitate diffusive oxygen uptake, and reduce asphyxiation risks) or consistently low metabolic rates (i.e., inactive insects, requiring limited internal oxygen stores). Alternatively, we predicted insects with long life-stage durations would have internal oxygen levels > 1 kPa (preventing high ROS levels that are believed to occur under tissue hypoxia). We tested these predictions by measuring partial pressures of oxygen (PO<sub>2</sub>) in tissues from juvenile and adult stages across 15 species comprising nine insect orders. Tissue PO<sub>2</sub> varied greatly (from 0 to 18.8 kPa) and variation across species and life stages was significantly related to differences in habitat, activity level, and life stage duration. Individuals with aquatic respiration sustained remarkably low PO<sub>2</sub> (mean = 0.88 kPa) across all species from Ephemeroptera (mayflies), Plecoptera (stoneflies), Trichoptera (caddisflies), and Diptera (true flies), possibly reflecting a widespread, but hitherto unknown, adaptation for extracting sufficient oxygen from water. For Odonata (dragonflies), aquatic juveniles had higher PO<sub>2</sub> levels (mean = 6.12 kPa), but these were still lower compared to terrestrial adults (mean = 13.3 kPa). Follow-up tests in juvenile stoneflies showed that tissue PO<sub>2</sub> remained low even when exposed to hyperoxia, suggesting that levels were down-regulated. This was further corroborated since levels could be modulated by ambient oxygen levels in dead individuals. In addition, tissue PO<sub>2</sub> was positively related to activity levels of insect life stages across all species and was highest in stages with short durations. Combined, our results support the idea that internal PO<sub>2</sub> is an evolutionarily labile trait that reflects the balance between oxygen supply and demand within the context of the environment and life-history of an insect.</span></p>
Extraction and characterization of TiO2 pigments from commercial paints for environmental studies
<p>Data supporting the study entitled "Extraction and characterization of TiO2 pigments from commercial paints for environmental studies".</p>
Imagenet Features Extracted with LBP
<p>This dataset contains features extracted from the Imagenet dataset using Local Binary Patterns Histograms. The LBP algorithm is configured with params <em>p=8</em>, <em>r=1</em>, <em>gridX=8</em> and <em>gridY=8</em>. Feature extraction was performed using the Python package <a href="https://github.com/jgoodman8/py-image-features-extractor" target="_blank" rel="nofollow noopener noreferrer">Py Image Feature Extractor</a>.</p>
Improved detection of DNA Schistosoma haematobium from eggs extracted by bead beating in urine
<p>Diagnosis of Schistosoma haematobium relies primarily on microscopical analysis of urine. The method is time consuming and<br> requires some expertise. Genus-specific real-time PCRs have been developed, but we still observed low sensitivity. In the present<br> study, in order to achieve a more sensitive DNA detection of eggs of S. haematobium in urine samples, we wanted to develop a<br> novel protocol of DNA extraction using mechanic disruption of eggs by bead beating as supplementary step. We tested<br> Schistosoma spp. internal transcribed spacer 2 real-time PCR after both methods with and without bead beating. First, we<br> preliminary assessed the DNA detection after bead beating using dilution of 2, 10, 50, and 90 eggs/10 mL, and the Ct value<br> analysis showed significant improved DNA detection per each point of egg concentration using the novel supplementary step.<br> Twenty microscopy positive and five microscopy negative urine samples were used to validate the procedure. All urines came<br> from imported cases and admitted at center for tropical medicine, and were examined by microscopy. PCR results after novel<br> method with bead beating showed 100% to be positive for S. haematobium, compared with 85% positive by our standard<br> extraction procedure. Results confirmed mechanic disruption of eggs by bead beating before DNA extraction to be highly<br> effective method for the detection of S. haematobium DNA in urine.</p>
Figure 5 from: Yusuf H, Kamarlis RK, Yusni Y, Fahriani M (2021) The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus). Pharmacia 68(2): 493-499. https://doi.org/10.3897/pharmacia.68.e63956
Figure 5 The means of AgNOR point on breast cancer tissue of experimental animals.
Figure 2 from: Yusuf H, Kamarlis RK, Yusni Y, Fahriani M (2021) The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus). Pharmacia 68(2): 493-499. https://doi.org/10.3897/pharmacia.68.e63956
Figure 2 The means of nodules volume observed on T1, T6, and T1.
Figure 1 from: Yusuf H, Kamarlis RK, Yusni Y, Fahriani M (2021) The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus). Pharmacia 68(2): 493-499. https://doi.org/10.3897/pharmacia.68.e63956
Figure 1 The means of total nodules observed on T5, T6, T11, and T17.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.