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2,322
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Dataset results
2,322 results for “Circulation”
Real time quantitative PCR analysis of serum circulating miRNAs from patients with head and neck tumors.
GEO Series GSE143491. Homo sapiens. 90 samples. Type: Expression profiling by RT-PCR.
Circulating exosomal microRNA profiling of diabetic patients with and without Metabolic Dysfunction-Associated Steatohepatitis
GEO Series GSE303156. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
A combination of circulating microRNA-375-3p, and chemokines CCL-11, CXCL12, and G-CSF differentiate Crohn’s Disease and Intestinal Tuberculosis
GEO Series GSE176255. Homo sapiens. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Novel circulating transcriptomic predictors of changes in maximal aerobic capacity in response to endurance training in healthy women
GEO Series GSE206505. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing.
Genome wide analysis of circulating miRNAs in growth hormone secreting pituitary neuroendocrine tumor patients' plasma
GEO Series GSE196647. Homo sapiens. 83 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Circulating monocytes from patients promote calcific aortic valve disease development
GEO Series GSE290104. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Circulating circRNA expression profiling of Papillary thyroid cancer
GEO Series GSE247120. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Lineage-committed osteoclast precursors circulate in blood and settle down into bone
GEO Series GSE26499. Mus musculus. 2 samples. Type: Expression profiling by array.
Brain Sensing of Metabolic State Regulates Circulating Monocytes
GEO Series GSE290851. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Feasibility of Circulating 5-Hydroxymethylcytosine Profiling in Osteosarcoma
To examine the utility and performance of 5-hydroxymethycytosine (5-hmC) profiling of cell-free DNA (cfDNA) as a biomarker of disease in patients with osteosarcoma. A Discovery cohort consisting of 5 patients with primary, localized osteosarcoma and an independent Validation cohort consisting of 17 patients with osteosarcoma. Serial cfDNA samples were collected for the majority of patients. Nano-hmC-Seal libraries were constructed from 1-10 ng of cfDNA. Briefly, cfDNA 5-hmC marks were subjected to enzymatic modification with UDP-N3-glucose, followed by chemical modification with biotin. Biotin-labeled cfDNA fragments were then pulled down using streptavidin beads, and PCR amplified to construct sequencing libraries. Using genes with differential 5-hmC deposition between osteosarcoma patients at diagnosis in the Discovery cohort and well children, hierarchal clustering identified two clusters of samples in the Validation cohort that were associated with disease status. Using a semi-quantitative osteosarcoma signature scoring system, the sensitivity and specificity to identify patients with active disease were 65% and 64%, respectively. Lung/soft tissue metastases were not readily identified. Despite limitations, 5-hmC profiling of cfDNA is feasible as a technique and further investigation with larger patient cohorts is warranted.
Dataset related to the article "Immature Circulating SP-B, Bound to HDL, Represents an early sign of Smoke-Induced Pathophysiological alterations"
<p>This record contains raw data related to the article "Immature Circulating SP-B, Bound to HDL, Represents an early sign of Smoke-Induced Pathophysiological alterations"</p> <p>Abstract</p> <p>Cigarette smoking is a major independent <em>risk factor</em> for cardiovascular diseases (CVD). The underlying mechanisms, however, are not clearly understood. Lungs are the primary route of exposure to smoke, with pulmonary cells and surfactant being the first structures directly exposed, resulting in the leakage of the immature proteoform of surfactant protein B (proSP-B). Herein, we evaluated whether proSP-B joins the cargo of HDL proteins in healthy young subjects (n=106) without any CVD risk factor other than smoking, and if HDL-associated proSP-B (HDL-SPB) correlated with pulmonary function parameters, systemic inflammation, and oxidative stress. At univariable analysis, HDL-SPB resulted significantly higher in smokers (2.2-fold, p<0.001) than in non-smokers. No significant differences have been detected between smokers and non-smokers for inflammation, oxidation variables, and alveolar-capillary diffusion markers. In a multivariable model, HDL-SPB was independently associated to smoking. In conclusion, HDL-SPB is not only a precocious and sensitive index of the acute effects of smoke but it might be also a potential causal factor in the onset of the vascular damage induced by modified HDL. These findings contribute to the emerging concept that the quality of the HDL proteome, rather than the quantity of particles, plays a central role in CVD risk protection.</p>
Dataset related to article "Subpopulations of Circulating Cells with Morphological Features of Malignancy Are Preoperatively Detected and Have Differential Prognostic Significance in Non-Small Cell Lung Cancer "
<p>This record contains raw data related to article “Subpopulations of Circulating Cells with Morphological Features of Malignancy Are Preoperatively Detected and Have Differential Prognostic Significance in Non-Small Cell Lung Cancer"</p> <p><strong>Background: </strong> Non-small cell lung cancer (NSCLC) frequently presents when surgical intervention is no longer feasible. Despite local treatment with curative intent, patients might experience disease recurrence. In this context, accurate non-invasive biomarkers are urgently needed. We report the results of a pilot study on the diagnostic and prognostic role of circulating tumor cells (CTCs) in operable NSCLC.</p> <p><strong>Methods: </strong> Blood samples collected from healthy volunteers (<em>n</em> = 10), nodule-negative high-risk individuals enrolled in a screening program (<em>n</em> = 7), and NSCLC patients (<em>n</em> = 74) before surgery were analyzed (4 mL) for the presence of cells with morphological features of malignancy enriched through the ISET<sup>®</sup> technology.</p> <p><strong>Results: </strong> CTC detection was 60% in patients, while no target cells were found in lung cancer-free donors. We identified single CTCs (sCTC, 46%) and clusters of CTCs and leukocytes (heterotypic clusters, hetCLU, 31%). The prevalence of sCTC (sCTC/4 mL ≥ 2) or the presence of hetCLU predicted the risk of disease recurrence within the cohort of early-stage (I-II, <em>n</em> = 52) or advanced stage cases (III-IVA, <em>n</em> = 22), respectively, while other tumor-related factors did not inform prognosis.</p> <p><strong>Conclusions: </strong> Cancer cell hematogenous dissemination occurs frequently in patients with NSCLC without clinical evidence of distant metastases, laying the foundation for the application of cell-based tests in screening programs. CTC subpopulations are fine prognostic classifiers whose clinical validity should be further investigated in larger studies.</p>
Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation
<p>This record contains raw data related to the article “Putative Circulating MicroRNAs Are Able to Identify Patients with Mitral Valve Prolapse and Severe Regurgitation”. Mitral valve prolapse (MVP) associated with severe mitral regurgitation is a debilitating disease with no pharmacological therapies available. MicroRNAs (miRNA) represent an emerging class of circulating biomarkers that have never been evaluated in MVP human plasma. Our aim was to identify a possible miRNA signature that is able to discriminate MVP patients from healthy subjects (CTRL) and to shed light on the putative altered molecular pathways in MVP. We evaluated a plasma miRNA profile using Human MicroRNA Card A followed by real-time PCR validations. In addition, to assess the discriminative power of selected miRNAs, we implemented a machine learning analysis. MiRNA profiling and validations revealed that miR-140-3p, 150-5p, 210-3p, 451a, and 487a-3p were significantly upregulated in MVP, while miR-223-3p, 323a-3p, 340-5p, and 361-5p were significantly downregulated in MVP compared to CTRL (<em>p</em> ≤ 0.01). Functional analysis identified several biological processes possible linked to MVP. In addition, machine learning analysis correctly classified MVP patients from CTRL with high accuracy (0.93) and an area under the receiving operator characteristic curve (AUC) of 0.97. To the best of our knowledge, this is the first study performed on human plasma, showing a strong association between miRNAs and MVP. Thus, a circulating molecular signature could be used as a first-line, fast, and cheap screening tool for MVP identification.</p>
Data set related to the article: "BPIFB4 Circulating Levels and Its Prognostic Relevance in COVID-19 "
<p>This record contains raw data related to the article: "BPIFB4 Circulating Levels and Its Prognostic Relevance in COVID-19".</p> <p> </p> <p>Abstract</p> <p>Aging and comorbidities make individuals at greatest risk of COVID-19 serious illness and mortality due to senescence-related events and deleterious inflammation. Long-living individuals (LLIs) are less susceptible to inflammation and develop more resiliency to COVID-19. As demonstrated, LLIs are characterized by high circulating levels of BPIFB4, a protein involved in homeostatic response to inflammatory stimuli. Also, LLIs show enrichment of homozygous genotype for the minor alleles of a 4 missense single-nucleotide polymorphism haplotype (longevity-associated variant [LAV]) in BPIFB4, able to counteract progression of diseases in animal models. Thus, the present study was designed to assess the presence and significance of BPIFB4 level in COVID-19 patients and the potential therapeutic use of LAV-BPIFB4 in fighting COVID-19. BPIFB4 plasma concentration was found significantly higher in LLIs compared to old healthy controls while it significantly decreased in 64 COVID-19 patients. Further, the drop in BPIFB4 values correlated with disease severity. Accordingly to the LAV-BPIFB4 immunomodulatory role, while lysates of SARS-CoV-2-infected cells induced an inflammatory response in healthy peripheral blood mononuclear cells in vitro, the co-treatment with recombinant protein (rh) LAV-BPIFB4 resulted in a protective and self-limiting reaction, culminating in the downregulation of CD69 activating-marker for T cells (both TCD4+ and TCD8+) and in MCP-1 reduction. On the contrary, rhLAV-BPIFB4 induced a rapid increase in IL-18 and IL-1b levels, shown largely protective during the early stages of the virus infection. This evidence, along with the ability of rhLAV-BPIFB4 to counteract the cytotoxicity induced by SARS-CoV-2 lysate in selected target cell lines, corroborates BPIFB4 prognostic value and open new therapeutic possibilities in more vulnerable people.</p>
Dataset: Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA
<p>This dataset contains the CRAM files of the samples used for the article "Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA" published in Genome Medicine.</p>
Identification of two autoantigens recognised by circulating autoantibodies as potential biomarkers for diagnosing giant cell arteritis
<p>Dataset associated with the papaer "Identification of two autoantigens recognised by circulating autoantibodies as potential biomarkers for diagnosing giant cell arteritis".</p> <p>This set of raw data cannot be made publicly available as containing sensitive information, but might be made available to interested researchers uponr reasonable requests. Please, forward your request to: p.meroni@auxologico.it.</p>
Data used in paper: The circulation response to resolved versus parametrized orographic drag over complex mountain terrains
<p>The data deposited here is a condensed set of the data used to generate the figures in the paper 'The circulation response to resolved versus parametrized orographic drag over complex mountain terrains', by Annelize van Niekerk, Irina Sandu and Simon Vosper.</p> <p>The data was generated using the Met Office Unified Model and the European Centre for Medium Range Weather Forecasts Integrated Forecasting System.</p> <p>Please contact Annelize.vanNiekerk@MetOffice.gov.uk for information on the data.</p> <p> </p>
Dataset related to article "Intrahepatic CD69 + Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression"
<p>This record contains raw data related to article “Intrahepatic CD69 + Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression"</p> <p>Abstract</p> <p><strong>Background: </strong> More than 50% of all patients with colorectal cancer (CRC) develop liver metastases (CLM), a clinical condition characterized by poor prognosis and lack of reliable prognostic markers. Vδ1 cells are a subset of tissue-resident gamma delta (γδ) T lymphocytes endowed with a broad array of antitumor functions and showing a natural high tropism for the liver. However, little is known about their impact in the clinical outcomes of CLM.</p> <p><strong>Methods: </strong> We isolated human γδ T cells from peripheral blood (PB) and peritumoral (PT) tissue of 93 patients undergone surgical procedures to remove CLM. The phenotype of freshly purified γδ T cells was assessed by multiparametric flow cytometry, the transcriptional profiles by single cell RNA-sequencing, the functional annotations by Gene Ontology enrichment analyses and the clonotype by γδ T cell receptor (TCR)-sequencing.</p> <p><strong>Results: </strong> The microenvironment of CLM is characterized by a heterogeneous immune infiltrate comprising different subsets of γδ tumor-infiltrating lymphocytes (TILs) able to egress the liver and re-circulate in PB. Vδ1 T cells represent the largest population of γδ TILs within the PT compartment of CLM that is greatly enriched in Vδ1 T effector (T<sub>EF</sub>) cells expressing constitutive high levels of CD69. These Vδ1 CD69<sup>+</sup> TILs express a distinct phenotype and transcriptional signature, show high antitumor potential and correlate with better patient clinical outcomes in terms of lower numbers of liver metastatic lesions and longer overall survival (OS). Moreover, intrahepatic CD69<sup>+</sup> Vδ1 TILs can egress CLM tissue to re-circulate in PB, where they retain a phenotype, transcriptional signature and TCR clonal repertoires resembling their liver origin. Importantly, even the increased frequencies of the CD69<sup>+</sup> terminally differentiated (T<sub>EMRA</sub>) Vδ1 cells in PB of patients with CLM significantly correlate with longer OS. The positive prognostic score of high frequencies of CD69<sup>+</sup> T<sub>EMRA</sub> Vδ1 cells in PB is independent from the neoadjuvant chemotherapy and immunotherapy regimens administered to patients with CLM prior surgery.</p> <p><strong>Conclusions: </strong> The enrichment of tissue-resident CD69<sup>+</sup> Vδ1 T<sub>EMRA</sub> cells re-circulating at high frequencies in PB of patients with CLM limits tumor progression and represents a new important clinical tool to either predict the natural history of CLM or develop alternative therapeutic protocols of cellular therapies.</p>
Circulating CircRNA expression profiling of Graves' disease
GEO Series GSE197637. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Circulating CD34+ Fibroblast Progenitors Participate in Heart Fibrosis of Allografts in Humans and Mice
GEO Series GSE300168. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.