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15,733 results for “article”
Dataset related to article "Tumor-associated macrophages and risk of recurrence in stage III colorectal cancer "
<p>This record contains raw data related to article “Tumor-associated macrophages and risk of recurrence in stage III colorectal cancer"</p> <p>Abstract</p> <p>Tumor-associated macrophages (TAMs) have a unique favorable effect on the prognosis of colorectal cancer (CRC), although their association with stage-specific outcomes remains unclear. We assessed the densities of CD68<sup>+</sup> and CD163<sup>+</sup> TAMs at the invasive front of resected CRC stage III CRC from 236 patients, 165 of whom received post-surgical FOLFOX treatment, and their relationship with disease-free survival (DFS). Associations between macrophage mRNAs and clinical outcome were investigated in silico in 59 stage III CRC and FOLFOX-treated patients from The Cancer Genome Atlas (TCGA). Biological interactions of SW480 and HT29 cells and macrophages with FOLFOX were tested in co-culture models. Low TAM densities were associated with shorter DFS among patients receiving FOLFOX (CD68<sup>+</sup> , p = 0.0001; CD163<sup>+</sup> , p = 0.0008) but not among those who were untreated. By multivariate Cox analysis, only low TAM (CD68<sup>+</sup> , p = 0.001; CD163<sup>+</sup> , p = 0.002) and nodal status (CD68<sup>+</sup> , p = 0.009; CD163<sup>+</sup> , p = 0.007) maintained an independent predictive value. In the TCGA cohort, high CD68 mRNA levels were associated with better outcome (p = 0.02). Macrophages enhanced FOLFOX cytotoxicity on CRC cells (p < 0.01), and drugs oriented macrophage polarization from M2- to M1-phenotype. Low TAM densities identify stage III CRC patients at higher risk of recurrence after adjuvant therapy, and macrophages can augment the chemo-sensitivity of micro-metastases.</p> <p><strong>Keywords: </strong></p>
Dataset related to article "DNAJB2-related Charcot-Marie-Tooth disease type 2: Pathomechanism insights and phenotypic spectrum widening"
<p>Genotype, phenotype and related pathomechanism insights of a family with a new DNAJB2 mutation;GENETICS RAW DATA OF DNAJB2 FAMILY: SANGER SEQUENCING, MLPA AND QPCR DATA </p>
Datset related to article "Pathways of follow-up care in an Italian center: retrospective study on patients with gliomas II and III"
<p>Database related to the descriptive statistics used to illustrate the characteristics of the sample and to identify the pathways of follow-up care in an Italian center.</p>
Dataset related to article "OCULAR PHENOTYPE AND ELECTRORETINOGRAM ABNORMALITIES IN LAFORA DISEASE AND CORRELATION WITH DISEASE STAGE"
<p>The dataset contains clinical data of a single Eye-Lafora patient involved in the study described at title followed at Fondazione Besta</p>
dataset related to article "Autophagy and Lysosomal Functionality in CMT2B Fibroblasts Carrying the RAB7K126R Mutation"
<p>Autophagy, lipophagy and lysosomal activity in CMT2B fibroblasts carrying the p.K126R RAB7 novel mutation, associated with predominantly motor phenotype</p>
DATASET RELATED TO ARTICLE "MONOALLELIC AND BIALLELIC MUTATIONS IN RELN UNDERLIE A GRADED SERIES OF NEURODEVELOPMENTAL DISORDERS
<p>clinical data of a single RELN case patient followed at Fondazione Besta involved in the study at title</p>
DATASET RELATED TO ARTICLE: "Multifaceted and Age-Dependent Phenotypes Associated With Biallelic PNPLA6 Gene Variants: Eight Novel Cases and Review of the Literature"
<p>Description of clinical and genetic data of eight PNPLA6 patients diagnosed at Besta Institute and summary of the literature previuos data for patients with the same disease.</p>
Dataset related to article "MESOCORTICOLIMBIC SYSTEM ABNORMALITIES IN CHRONIC CLUSTER HEADACHE PATIENTS A NEURAL SIGNATURE"
<p>Volumes of the subcortical regions expressed as a percentage of total intracranial volume (TIV). Data are obtained with Freesurfer software</p>
dataset related to article " Social Network and Environment as determinants of diability and quality of life in aging: results from an italian study"
<p>The “TAPAS in Aging” database includes data related to socio-demographic information, health condition, quality of life, social network and environment of people aged more than 50 years in Lombardy region.</p>
datset related to article "PATHOLOGICAL MITOPHAGY DISRUPTS MITOCHONDRIAL HOMEOSTASIS IN LEBER'S HEREDITARY OPTIC NEUROPATHY"
<p><strong>Raw data from Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy – experiments of</strong> <strong>mito-autophagy present in specific regions of the idNeurons (soma and axon-dendrite (Ax-De) regions) </strong></p>
Dataset related to article "Acute Blood Levels of Neurofilament Light Indicate One-Year White Matter Pathology and Functional Impairment in Repetitive Mild Traumatic Brain Injured Mice"
<p>Raw data related to the article "Acute Blood Levels of Neurofilament Light Indicate One-Year White Matter Pathology and Functional Impairment in Repetitive Mild Traumatic Brain Injured Mice"</p>
Dataset related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation"
<p>This record contains raw data related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation".</p> <p>Abstract</p> <p><strong>Background: </strong>Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response of these cells to mechanical cues through activation of the Hippo transcriptional pathway. The objective of the present study was to assess the role of cellular/nuclear straining forces acting in myofibroblast differentiation of cardiac stromal cells under the control of YAP (yes-associated protein) transcription factor and to validate this finding using a pharmacological agent that interferes with the interactions of the YAP/TAZ (transcriptional coactivator with PDZ-binding motif) complex with their cognate transcription factors TEADs (TEA domain transcription factors), under high-strain and profibrotic stimulation.</p> <p><strong>Methods: </strong>We employed high content imaging, 2-dimensional/3-dimensional culture, atomic force microscopy mapping, and molecular methods to prove the role of cell/nuclear straining in YAP-dependent fibrotic programming in a mouse model of ischemia-dependent cardiac fibrosis and in human-derived primitive cardiac stromal cells. We also tested treatment of cells with Verteporfin, a drug known to prevent the association of the YAP/TAZ complex with their cognate transcription factors TEADs.</p> <p><strong>Results: </strong>Our experiments suggested that pharmacologically targeting the YAP-dependent pathway overrides the profibrotic activation of cardiac stromal cells by mechanical cues in vitro, and that this occurs even in the presence of profibrotic signaling mediated by TGF-β1 (transforming growth factor beta-1). In vivo administration of Verteporfin in mice with permanent cardiac ischemia reduced significantly fibrosis and morphometric remodeling but did not improve cardiac performance.</p> <p><strong>Conclusions: </strong>Our study indicates that preventing molecular translation of mechanical cues in cardiac stromal cells reduces the impact of cardiac maladaptive remodeling with a positive effect on fibrosis.</p>
Dataset related to article "Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation "
<p>This record contains raw data related to article “Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation"</p> <p><strong>Background: </strong> The total marrow and lymph node irradiation (TMLI) target includes the bones, spleen, and lymph node chains, with the latter being the most challenging structures to contour. We evaluated the impact of introducing internal contour guidelines to reduce the inter- and intraobserver lymph node delineation variability in TMLI treatments.</p> <p><strong>Methods: </strong> A total of 10 patients were randomly selected from our database of 104 TMLI patients so as to evaluate the guidelines' efficacy. The lymph node clinical target volume (CTV_LN) was recontoured according to the guidelines (CTV_LN_GL_RO1) and compared to the historical guidelines (CTV_LN_Old). Both topological (i.e., Dice similarity coefficient (DSC)) and dosimetric (i.e., V95 (the volume receiving 95% of the prescription dose) metrics were calculated for all paired contours.</p> <p><strong>Results: </strong> The mean DSCs were 0.82 ± 0.09, 0.97 ± 0.01, and 0.98 ± 0.02, respectively, for CTV_LN_Old vs. CTV_LN_GL_RO1, and between the inter- and intraobserver contours following the guidelines. Correspondingly, the mean CTV_LN-V95 dose differences were 4.8 ± 4.7%, 0.03 ± 0.5%, and 0.1 ± 0.1%.</p> <p><strong>Conclusions: </strong> The guidelines reduced the CTV_LN contour variability. The high target coverage agreement revealed that historical CTV-to-planning-target-volume margins were safe, even if a relatively low DSC was observed.</p>
Datasheets of article "Dual-chamber microbial fuel cell with denitrifying biocathode for the treatment of cassava processing wastewater"
<p>Datasheets related to the article entitled "Dual-chamber microbial fuel cell with denitrifying biocathode for the treatment of cassava processing wastewater".</p>
Dataset related to article "Important functional role of the protein Osteopontin in the progression of malignant pleural mesothelioma"
<p>This record contains raw data related to article “Important functional role of the protein Osteopontin in the progression of malignant pleural mesothelioma"</p> <p>Background: Malignant Pleural Mesothelioma (MPM) is an aggressive cancer of the mesothelial lining associated with exposure to airborne non-degradable asbestos fibers. Its poor response to currently available treatments prompted us to explore the biological mechanisms involved in its progression. MPM is characterized by chronic non-resolving inflammation. in this study we investigated which inflammatory mediators are mostly expressed in biological tumour samples from MPM patients.<br> Methods: Expression and quantification of Osteopontin (OPN) was detected in tumour and plasma samples of MPM patients by mRNA, immunohistochemistry and ELISA. The functional role of OPN was investigated in mouse MPM cell lines in vivo using an orthotopic syngeneic mouse model.<br> Results: In patients with MPM, the protein OPN was significantly more expressed in tumours than in normal pleural tissues and predominantly produced by mesothelioma cells; plasma levels were elevated in patients and associated with poor prognosis. However, modulation of OPN levels was not significantly different in a series of 18 MPM patients receiving immunotherapy with durvalumab alone or with pembrolizumab in combination with chemotherapy, some of whom achieved a partial clinical response. Two established murine mesothelioma cell lines: AB1 and AB22 of sarcomatoid and epithelioid histology, respectively, spontaneously produced high levels of OPN. Silencing of the OPN gene (Spp1) dramatically inhibited tumour growth in vivo in an orthotopic model, indicating that OPN has an important promoting role in the proliferation of MPM cells. Treatment of mice with anti-CD44 mAb, blocking a major OPN receptor, significantly reduced tumour growth in vivo.<br> Conclusions: These results demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumour progression in vivo. These findings have translational potential to improve the therapeutic response of human MPM</p>
Dataset for article "Anxiety and emotional support among first-year college students during the transition from distance to face-to-face learning during COVID-19"
<p>The attached file contains de-identified data from information collected for reporting in a study pending publication in PLOS One entitled "Anxiety and emotional support among first-year college students during the transition from distance to face-to-face learning during COVID-19".</p>
code for the article "No evidence of transmitting meteorological droughts of North Atlantic Ocean to the Asian water tower"
<p>This file contains all the codes used in this study along with the data for the main figures.</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Dataset related to article "Genomic instability analysis in DNA from Papanicolaou test provides proof-of-principle early diagnosis of high-grade serous ovarian cancer"
<p>This record contains data related to the article "Genomic instability analysis in DNA from Papanicolaou test provides proof of principle early diagnosis of high-grade serous ovarian cancer".</p><p>Abstract</p><p>Late diagnosis and the lack of screening methods for early detection define high-grade serous ovarian cancer (HGSOC) as the gynecological malignancy with the highest mortality rate. In the work presented here, we investigated a retrospective and multicentric cohort of 250 archival Papanicolaou (Pap) test smears collected during routine gynecological screening. Samples were taken at different time points (from 1 month to 13.5 years before diagnosis) from 113 presymptomatic women who were subsequently diagnosed with HGSOC (pre-HGSOC) and from 77 healthy women. Genome instability was detected through low-pass whole-genome sequencing of DNA derived from Pap test samples in terms of copy number profile abnormality (CPA). CPA values of DNA extracted from Pap test samples from pre-HGSOC women were substantially higher than those in samples from healthy women. Consistently with the longitudinal analysis of clonal pathogenic <i>TP53</i> mutations, this assay could detect HGSOC presence up to 9 years before diagnosis. This finding confirms the continual shedding of tumor cells from fimbriae toward the endocervical canal, suggesting a new path for the early diagnosis of HGSOC. We integrated the CPA score into the EVA (early ovarian cancer) test, the sensitivity of which was 75% (95% CI, 64.97 to 85.79), the specificity 96% (95% CI, 88.35 to 100.00), and the accuracy 81%. This proof-of-principle study indicates that the early diagnosis of HGSOC is feasible through the analysis of genomic alterations in DNA from endocervical smears.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.