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FIGURE 2 in Varicosporellopsis shangrilaensis sp. nov. (Nectriaceae, Hypocreales), a new terricolous species isolated from the rhizosphere soil of Astragalus polycladus in northwestern Yunnan, China
FIGURE 2. Varicosporellopsis shangrilaensis (CGMCC 3.21000, holotype). a Colony. b Macroconidia. c, e Conidiophores and conidiogenous cells. d Microconidia. Scale bars: a = 10 mm, b, d, e = 10 μm, c = 20 μm.
FIGURE 1 in Varicosporellopsis shangrilaensis sp. nov. (Nectriaceae, Hypocreales), a new terricolous species isolated from the rhizosphere soil of Astragalus polycladus in northwestern Yunnan, China
FIGURE 1. Maximum likelihood tree based on combined ITS, LSU, TUB and ACT sequence data from 42 Nectriaceae isolates. Bootstrap support values for maximum likelihood (black) equal to or greater than 70% and Bayesian posterior probabilities values (red) equal to or greater than 0.90 are indicated near the nodes. The two new isolates are in blue and type isolates are in bold. The tree is rooted with Pseudonectria buxi (CBS 114049 and CBS 324.53).
Fig. 2 in The antioxidant potential of retrochalcones isolated from liquorice root: A comparative DFT study
Fig. 2. Optimized geometries of the retrochalcones (1–6) in the gas phase (Mittal and Kakkar, 2021).
Fig. 1 in The antioxidant potential of retrochalcones isolated from liquorice root: A comparative DFT study
Fig. 1. The basic skeleton of a retrochalcone with atomic labeling and the list of substituents for the different retrochalcones (1–6).
Fig. 3 in The antioxidant potential of retrochalcones isolated from liquorice root: A comparative DFT study
Fig. 3. Probable routes associated with different antioxidant mechanisms of a retrochalcone molecule (Ch(OH)n).
Fig. 7 in Unusual matrine-adenine hybrids isolated from Sophora davidii and their inhibitory effects on human cytomegalovirus
Fig. 7. Molecular docking model of 1 (A), 2 (B), 3 (C), and 4 (D) bound to the HCMV protease (PDB: 2WPO). Hydrogen bond interactions are depicted with red dashes, while π–π and π–cation stacking interactions are displayed with green and yellow dashes, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 8 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 8. (A) The 3D structure and hydrogen bond interaction of compound 18 with FXR at the 50th ns MD stimulation. (B) The agonistic activity of compound 18 against the wild-type, mutant R341V, or S342V FXR. Data were shown as the mean ± SD, n = 4 (*p <0.05, **p <0.01, ***p <0.001 compared to the Ctrl group; #p <0.05, ##p <0.01, ###p <0.001 compared to the WT group).
Fig. 7 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 7. The RMSD (A) and RMSF (B) of compound 18 with FXR in 50 ns MD stimulation. (C) The volume of pock for a complex of compound 18 and FXR in 50 ns MD stimulation. (D–F) The energy of the complex (D), energy of contribution (E), and hydrogen bond number (F) of compound 18 with FXR in the 50 ns MD stimulation. (G) The distance of compound 18 with amino acid residues Val325, Met328, and Phe329. (H) The distance of compound 18 with amino acid residues Ser332 and Tyr369.
Fig. 5 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 5. (A) Effects of compound 18 (2 μM) towards FXR, SHP1, and BSEP mRNA levels. (B) Effects of compound 18 (2 μM) towards FXR, SHP1, FGF, and BSEP expression levels. (C) Quantitative analysis of FXR, SHP1, FGF, and BSEP expression levels. Data were shown as the mean ± SD, n = 3 (*p <0.05, **p <0.01, ***p <0.001 compared to the Ctrl group). CDCA (80 μM) was used as the positive control.
Fig. 4 in Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR
Fig. 4. Experimental and calculated ECD spectra of 1 (A) and 5–7 (B–D) at the CAM-B3LYP/def-tzvp level.
Fig. 5 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 5. Feline calicivirus (FCV)-inactivating activities of Dracocephalum spp.-derived compounds. Compounds isolated from D. fruticulosum (A and B), D. nutans (C and D), and D. foetidum (E and F) were incubated with FCV suspensions for 48 h (A, C, and E) and 6 h (B, D, and F), respectively. Viral titer data are presented as the mean ± standard deviation (n = 3–7 per group). *p <0.05; **p <0.01 vs. the dimethyl sulfoxide (DMSO) control group (Student's t-test). TCID50, 50% tissue culture infectious dose.
Fig. 4 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 4. Key heteronuclear multiple bonds (HMBC) and nuclear Overhauser effect (NOE) correlations of compounds 19–21.
FIGURE 1 in Tolypocladium rhizomatum sp. nov.: an endophytic species isolated from the rhizome of Polygonatum cyrtonema
FIGURE 1. Phylogenetic relationships of Tolypocladium rhizomatum sp. nov. and its allies within Ophiocordycipitaceae inferred from the combined ITS, SSU, LSU, TEF1-α, and RPB1 sequences, using maximum likelihood and Bayesian analysis. The numbers on the nodes indicate the ML bootstrap values or Bayesian posterior probabilities, above 75% (MLBS) or 0.8 (BIPP), respectively. Bold lines indicate that the support for the tree analyses was 100% (MLBS) or 1.0(BIPP). *Represents the ex-type strain.
FIGURE 2 in Tolypocladium rhizomatum sp. nov.: an endophytic species isolated from the rhizome of Polygonatum cyrtonema
FIGURE 2. Morphology of Tolypocladium rhizomatum sp. nov.. A-B: Colonies on PDA. C–D: Phialides and conidia on PDA. E–F: Colonies and conidia on MEA. G–H: Phialides on MEA. I–J: Colonies on OA. K–L: Phialides and conidia on OA. Scale bars: A–B, E–F, I–J=15mm; C–D, G–H, K–L=10μm.
Data from: Patterns in antipredator armature reduction and maintenance in isolated spring populations of an amphipod crustacean
<p class="xmsonormal"><span>Organisms colonizing new habitat can undergo adaptive change due to novel selective landscapes encountered in the new environment. Examples in nature where development of the same traits has repeatedly occurred on multiple independent occasions upon colonizing a novel habitat represent instances of parallel evolution. Here we test whether the colonization of spring habitat by the principally lacustrine amphipod crustacean <em>Pallaseopsis quadrispinosa </em>has resulted in parallel evolution in armature traits using empirical data on morphology and mitochondrial DNA and through a breeding experiment. Analysis of mtDNA CO1 sequences shows that the spring populations share no common history and have evolved in isolation from each other and from their neighbouring lake populations since deglaciation approximately 12000 years ago and are now fixed for different haplogroups. Dorsal spines and lateral projections were absent or less developed in all spring populations than in lake populations. Variation in armature development also could be explained by predator presence as populations with fish predators exhibited more developed spines than those without fish. In a laboratory breeding experiment, hybrid Spring X Lake F1 offspring had intermediate development of armature when compared to offspring of Lake X Lake and Spring X Spring matings. The results support the hypothesis that armature reduction has independently evolved on multiple occasions in <em>P. quadrispinosa. </em>Recent research has questioned the degree to which parallel evolution actually explains variance in traits. Taking into account predation regime, sexual dimorphism and mineral composition of the trait, a more precise understanding of the factors influencing parallel evolution emerges.</span></p>
Learning to Isolate Muons in Data
<p>This dataset corresponds to "Learning to Isolate Muons in Data" (2306.15737) and is meant for use with the code at https://github.com/Edwit4/learning_to_isolate_muons_in_data/.</p>
Figure 3: Distribution of MDR isolates count among total isolates of ESKAPE pathogens
<p><strong>Figure 3: Distribution of MDR isolates count among total isolates of ESKAPE pathogens</strong></p>
Camponotus fellah cDNA lists for: Social isolation shortens lifespan through oxidative stress in ants
<p>Social isolation negatively affects health, induces detrimental behaviors, and shortens lifespan in social species. Little is known about the mechanisms underpinning these effects because model species are typically short-lived and non-social. Using colonies of carpenter ant <em>Camponotus</em> <em>fellah</em>, we show that social isolation induces hyperactivity, alters space-use, and reduces lifespan via changes in the expression of genes with key roles in oxidation-reduction and an associated accumulation of reactive oxygen species. These physiological effects are localized to the fat body and oenocytes, which perform liver-like functions in insects. We use pharmacological manipulations to demonstrate that the oxidation-reduction pathway causally underpins the detrimental effects of social isolation on behavior and lifespan. These findings have important implications for our understanding of how social isolation affects behavior and lifespan in general.</p>
Fig. 8 in Guide isolation of guaiane-type sesquiterpenoids from Daphne tangutica maxim. And their anti-inflammatory activities
Fig. 8. Inhibitory effects of 1–32 against LPS-induced NO production in BV-2 cells. Mean ± SD of three replicates is shown. *p <0.05, *p <0.01 with the LPS group. ###p <0.001 with the control group.
Fig. 4 in Guide isolation of guaiane-type sesquiterpenoids from Daphne tangutica maxim. And their anti-inflammatory activities
Fig. 4. Key HMBC (arrows in blue) and 1 H– 1 H COSY (bold in black) correlations of undescribed compounds 1-13. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.