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4,359 results for “Insulin”
Antigen-specific immunotherapy with a CD4 hybrid insulin peptide neoepitope arrests CD8 T cell differentiation in islet grafts
GEO Series GSE299087. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans
GEO Series GSE65221. Homo sapiens. 136 samples. Type: Expression profiling by array.
Single Cell Landscape of Left Atria Reveals Amphiregulin and Insulin-like Growth Factor 1 as Surrogate Markers in Patients with Atrial Fibrillation.
GEO Series GSE261170. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
An insulin-sensitive circular RNA that regulates lifespan in Drosophila
GEO Series GSE130158. Drosophila melanogaster. 78 samples. Type: Expression profiling by high throughput sequencing; Other.
Acyl-CoA synthetase 1 in differentiated adipocytes from small for gestational age neonates: Putative association with fetal programming of cellular insulin sensitivity and lipid content [ChIP-Seq]
GEO Series GSE64697. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on a high-fat, high-sugar diet.
GEO Series GSE50005. Macaca mulatta; Homo sapiens. 45 samples. Type: Expression profiling by array.
TCTP participate in hepatic metabolism with regulate the gene expression involved in insulin resistance
GEO Series GSE143409. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Intrauterine Botulinum Toxin A administration promotes thin endometrium regeneration in a manner dependent on regulatory effect of insulin-like growth factor-binding protein 3 on osteopontin proteolyt
GEO Series GSE207379. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
GEO Series GSE78183. Mus musculus. 338 samples. Type: Expression profiling by high throughput sequencing.
Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes
GEO Series GSE213062. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
The hepatic methylome of liver-specific insulin receptor knockout (LIRKO) mouse offspring
GEO Series GSE141379. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
Supplementary materials-Anti-Insulin Resistance Mechanism of Action of Glycyrrhizic Acid An in Vitro Investigation Based on in Silico Prediction
<p>The supplementary materials of the article "Anti-Insulin Resistance Mechanism of Action of Glycyrrhizic Acid: An <em>in Vitro</em> Investigation Based on <em>in Silico</em> Prediction"</p>
Data from: Remission of type 2 diabetes following a short-term intervention with insulin Glargine, Metformin and Dapagliflozin.
<p>This dataset contains Supplemental Tables for the manuscript.</p>
Representative Western blots showing the ratio of total expression of phosphorylated and unphosphorylated proteins involved in insulin signaling pathway in the red gastrocnemius muscle in control and HFD groups after chronic CBD treatment.
<p>Representative Western blots showing the ratio of total expression of phosphorylated and unphosphorylated proteins involved in insulin signaling pathway e.g., phosphorylated insulin receptor substrate 1/insulin receptor substrate 1 - pIRS-1/IRS-1 (A), phosphorylated protein kinase B/protein kinase B - pAkt/Akt (B), phosphorylated AS160 protein/AS160 protein – pAS160/AS160 (C) and phosphorylated glycogen synthase kinase 3/glycogen synthase kinase 3 - pGSK-3/GSK-3 (D) in the red gastrocnemius muscle in control and HFD groups after chronic CBD treatment. The total expressions of the above proteins were presented as a percentage difference compared to the control group, which was set as 100%. The data are expressed as mean values ± SD, n = 6 in each group. ap < 0.05 significant difference: control group vs. examined group; bp < 0.05 significant difference: HFD vs. HFD+CBD.</p>
Data from: Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model
Background: The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. Here, we sought to compare originator and non-originator copies of insulin glargine for innate immune activity and mechanisms leading to differences in these response profiles in an in vitro model of human immunity. Methods: An endothelial/dendritic cell-based innate immune model was used to study antigen-presenting cell activation, cytokine secretion, and insulin receptor signalling pathways induced by originator and non-originator insulin glargine products. Mechanistic studies included signalling pathway blockade with specific inhibitors, analysis of the products in a Toll-like receptor reporter cell line assay, and insulin removal from the products by immunopurification. Findings: All insulin glargine products elicited at least a minor innate immune response comparable to human insulin, but some lots of a non-originator copy product induced the elevated secretion of the cytokines, IL-8 and IL-6. In studies aimed at addressing the mechanisms leading to differential cytokine production by these products, we found (1) the inflammatory response was not mediated by bacterial contaminants, (2) the innate response was driven by the insulin receptor through the MAPK pathway, and (3) the removal of insulin significantly reduced their capacity to induce innate activity. No evidence of product aggregates was detected, though the presence of some high molecular weight proteins argues for the presence of insulin dimers or others contaminants in these products. Conclusion: The data presented here suggests some non-originator insulin glargine product lots drive heightened in vitro human innate activity and provides preliminary evidence that changes in their biochemical composition (dimers, impurities) might be responsible for their greater immunostimulatory potential.
Data from: Higher insulin resistance & adiposity in post-menopausal women with breast cancer treated with aromatase inhibitors
Context: Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy in post-menopausal breast cancer. Objective: We hypothesized that aromatase inhibitors induce obesity and insulin resistance when used in treatment of breast cancer. Design: Case-control study Setting: University teaching hospital Participants: 20 post-menopausal breast cancer patients, treated with aromatase inhibitor and 20 age-matched controls. Main outcome measures: Primary outcome measure was insulin sensitivity index – Matsuda, derived from a 75g oral glucose tolerance test. Body composition was assessed by DEXA and subcutaneous adipose tissue biopsies obtained for assessment of mRNA transcript levels. Data are mean ± SEM (inhibitor vs controls). Results: Aromatase inhibitor therapy was associated with significantly lower insulin sensitivity (5.15 ± 0.45 vs. 6.80 ± 0.64, P = 0.041), higher peak insulin concentration following OGTT (693.4 ± 78.6 vs. 527.6 ± 85.5 pmol/L, P = 0.035), greater percentage body fat (38.4 ± 1.0 vs. 34.6 ± 1.3 %, P = 0.026), and higher plasma leptin concentration (23.5 ± 2.8 vs. 15.5 ± 2.3 ng/mL, P = 0.035). Conclusions: Women who received aromatase inhibitors for post-menopausal breast cancer have greater percentage body fat and insulin resistance compared to controls with no history of breast cancer.
Insulin is expressed by enteroendocrine cells during human fetal development
<p>Codes and single cell data for "Insulin is expressed by enteroendocrine cells during human fetal development" paper.</p> <p><strong>Folder: Cell_Ranger_output</strong><br> Data produced using 10x sequencing.<br> This folder contains all the Cell Ranger output raw files from all 6 subjects used for single cell RNA sequencing (2x Neonatal- S1056, S1127, 2x fetal 21 weeks GA- S1100A, S1102, 2x fetal 23weeks GA S1130, S1143).<br> Each subject has two 10X runs- one done on CD45 negatively selected small intestinal cells and the other on non-selected small intestinal cells.</p> <p><strong>Folder: Matlab_codes_and_struct</strong><br> Done on Matlab R2019b<br> This folder contains two scripts and their input files.<br> 1. Global_transcriptome_similarity_Matlab.m - Matlab script to create the distance from adult beta cells from Extended Data Fig 2<br> 2. sturcture_for_global_similarity.mat - input file for "Global_transcriptome_similarity_Matlab.m" script<br> 3. SCENIC_analysis_matlab.m - Matlab script to create clustergram of transcription factors with the most differential activities in the different cell types from Extended Data Fig 3<br> 4. EECs_mat_file.mat - input file for "SCENIC_analysis_matlab.m" script</p> <p><strong>Folder: Seurat_pipline_and_background_subtraction</strong><br> Done with Seurat package version 3.2.2<br> This folder contains R scripts for Seurat analysis and script for background (BG) subtraction of the data.<br> 1. BG_subtraction_before_seurat.R - Script that creates a BG subtracted matrix for each Cell Ranger output before Seurat analysis.<br> 2. seurat_pipline_all_cells.R - Script for Seurat analysis for the full atlas and the Enteroendocrine subset.</p> <p><strong>Folder: Count_tables</strong><br> This folder contains three BG subtracted UMI tables and their additional metadata.<br> 1. BG_subtracted_count_table_all_cells_before_filt.txt - BG subtracted UMI table of all cells before Seurat filtration and analysis (input file for "seurat_pipline_all_cells.R" script).<br> 2. Metadata_all_cells_before_filteration.xlsx - Metadata for "BG_subtracted_count_table_all_cells_before_filt.txt " (input file for "seurat_pipline_all_cells.R" script).<br> 3. BG_subtracted_count_table_all_cells_after_filt.txt - BG subtracted UMI table of all cells after Seurat filtration and analysis.<br> 4. Metadata_all_cells_after_filteration.xlsx - Metadata for "BG_subtracted_count_table_all_cells_after_filt.txt".<br> 5. BG_sub_count_table_enteroendocrine_cells.txt - BG subtracted UMI table of enteroendocrine cells subset after Seurat filtration and analysis. <br> 6. Metadata_enteroendocrine_cells.xlsx - Metadata for "BG_sub_count_table_enteroendocrine_cells.txt".</p>
STROBE checklist for Association between Serum Insulin and Interleukin-6 levels with Breast Cancer in Post-Menopausal Iraqi Women
<p>STROBE checklist for Association between Serum Insulin and Interleukin-6 levels with Breast Cancer in Post-Menopausal Iraqi Women</p>
A Study Of Rosiglitazone Plus Insulin To Treat Type 2 Diabetes Mellitus Patients
ClinicalTrials.gov study NCT00349427. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Exercise on Insulin Resistance
ClinicalTrials.gov study NCT01941277. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.