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opennotspecifiedFeb 2023View details →

Fig. 2 in Guide isolation of guaiane-type sesquiterpenoids from Daphne tangutica maxim. And their anti-inflammatory activities

Fig. 2. The molecular network of D. tangutica, in which chemical classification was achieved by MolNetEnhancer at the subclass level, except for the heteromonocyclic compounds classified at the molecular framework level.

Fig. 2. 1H–1H in Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells

Fig. 2. 1H–1H COSY and HMBC key correlations of 3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (3).

Fig. 1. 3 in Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells

Fig. 1. 3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)- 1,2,4-oxadiazole (3).

Fig. 10 in Benzobicyclic ketones, cycloheptenone oxide derivatives, guaiane-type sesquiterpenes, and alkaloids isolated from Taraxacum mongolicum Hand.-Mazz.

Fig. 10. NO production inhibited by compounds 3 and 11 (A) and IL-6 mRNA levels altered by compounds 3 and 11 (B) after RAW 264.7 macrophages were induced by 100 ng/mL LPS (DMSO was the blank control). The data are presented as the means ± SD (n = 3). Comparisons were made between the DMSO and LPS groups (##p <0.01) and between the LPS and different compound groups (*p <0.05; **p <0.01).

Fig. 7. Compounds 2–4, 7 in Guided isolation of daphnane-type diterpenes from Daphne genkwa by molecular network strategies

Fig. 7. Compounds 2–4, 7, and 9 induced apoptosis in A549 cells in 50 μM. (A) Annexin V-FITC/PI staining assay of A549 cells was analyzed by flow cytometry. (B) Quantification of data in (A). The percentage of apoptotic cells was calculated in the bar chart. (*, P <0.05. **, P <0.01. ***, P <0.001. ****, P <0.0001).

Fig. 1 in Guided isolation of daphnane-type diterpenes from Daphne genkwa by molecular network strategies

Fig. 1. MS/MS-based molecular network of extract fractions from Daphne genkwa with the expanded protonated cluster. Molecular ions are represented as pie charts and node sizes based on the degree of correlation between compounds.

Fig. 3 in Guided isolation of daphnane-type diterpenes from Daphne genkwa by molecular network strategies

Fig. 3. ORTEP drawing of compound 1 (displacement ellipsoids are drawn at the 30% probability level).

opennotspecifiedFeb 2022View details →

Fig. 4 in Isolation and structural elucidation of bioactive obovatol dimeric neolignans from the bark of Magnolia officinalis var. biloba

Fig. 4. Neuroprotective effects of racemate 1, (+)-1, ()-1, and 5 on glutamic acid-induced injury of SK-N-SH cells (10 μM, means ± SEM, n = 3). ***p <0.001, *p <0.05, **p <0.01. Positive controls: n-butylphthalide (NBP).

Fig. 3 in Isosteroidal alkaloids of Fritillaria taipaiensis and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity

Fig. 3. Key NOESY () correlations for compounds 1–4 [some hydrogens were removed for a clearer exhibition of their 3D structures].

opennotspecifiedOct 2022View details →

Fig. 10. Previously undescribed homogentisic acid derivatives isolated from G in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021

Fig. 10. Previously undescribed homogentisic acid derivatives isolated from G. Brevipes in the Siparunaceae family.

Fig. 5 in Two pairs of undescribed enantiomers isolated from the fungus Penicillium griseofulvum

Fig. 5. The binding modes of 4 (A) and 7 (B) with human α-glucosidase (PDB ID: 3TOP). Hydrogen bond interactions were depicted with red dotted lines in Å. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 3. Linear correlation between the experimental and calculated 13C in Two pairs of undescribed enantiomers isolated from the fungus Penicillium griseofulvum

Fig. 3. Linear correlation between the experimental and calculated 13C NMR chemical shift of 1A and 1B and their compared 13C NMR data (Δδ δ δ). = adj_calcd – expt MG857577) is 99% identical to P. griseofulvum isolate M12 (KX302025.1) and P. griseofulvum strain Yup08 (HQ262520.1).

opencc-by-4.0Aug 2023View details →

Isolation, identification, and structure elucidation of Beta-sitosterol from Iraqi Plantago major using GC-MS, HPTLC, NMR, and FTIR

Isolation, identification, and structure elucidation of Beta-sitosterol from Iraqi Plantago major using GC-MS, HPTLC, NMR, and FTIR

FIGURE 2 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 2. Maximum likelihood phylogenetic tree based on combined SSU-ITS-LSU sequence data for Sympoventuriaceae. Bootstrap support values of maximum likelihood greater than 60% and Bayesian posterior probabilities (BYPP) greater than 0.95 are indicated above the nodes. Newly added strains are in blue and ex-type strains are in bold. The tree is rooted to Venturia inaequalis (CBS 594.70 and CBS 815.69). Isolated substrates are indicated in triangles. Black: Human/ animal, green: plants, brown: soil, purple: rock/ sediments, blue: aquatic habitat. unknown: empty

FIGURE 5 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 5. Verruconis soli (MFLU22-0257, holotype) a. Colony from above (on PDA). b. Colony from below (on PDA). c. Sporulated colony. d. Melanized hyphae. e. Hyaline hyphae f–l. Conidiogenesis. m–r. Conidia. Scale bars: e = 15 μm, d, f–k = 10 μm, l–r = 5 μm.

FIGURE 6 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 6. Verruconis thailandica (MFLU22-0258, new record) a. Colony from above (on PDA). b. Colony from below (on PDA). c. Sporulated colony with conidial attachments on the mycelium. d. Immature hyphae e. Mature septate hyphae. f. Conidiogenesis synnematous. g–j. Conidiogenesis mononematous conidiophores. k–p Conidia. Scale bars: d, e = 20 μm, f–l, n = 10 μm, m, o, p = 5 μm.

FIGURE 4 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 4. Curvularia chiangmaiensis (MFLU22-0252, new record) a. Colony from above (on PDA). b. Colony from below (on PDA). c. Sporulated colony with conidial attachments on the mycelium. d. Immature hyphae e. Mature melanized hyphae. f. Hyaline chlamydospores. g. Melanized chlamydospores h. Macronematous conidiogenesis on the conidiophore. i–m. Conidiogenesis. n–s. Conidia. Scale bars: g = 25 μm, d–f, h–l = 20 μm, m–s= 10 μm

FIGURE 1 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 1. (Continued) Maximum likelihood phylogenetic tree generated of the combined ITS-GAPDH-tef1-α sequence data for Curvularia.

FIGURE 3 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 3. Curvularia chiangraiensis (MFLU22-0256, holotype). a. Colony from above (on PDA). b. Colony from below (on PDA). c. Sporulated colony with conidial attachments on the mycelium. d. Immature hyphae. e. Mature melanized hyphae. f–k. conidiogenesis. l–p. Conidia. Scale bars: g = 25 μm, d–f, h–l = 20 μm, g, m–p= 10 μm.

FIGURE 1 in Isolation and characterization of novel Dothideomycetes species from forest soils in Chiang Rai and Krabi (Thailand): additions to the diversity of Curvularia and Verruconis

FIGURE 1. Maximum likelihood phylogenetic tree generated of the combined ITS-GAPDH-tef1-α sequence data for Curvularia. Bootstrap support values of maximum likelihood greater than 60% and Bayesian posterior probabilities (BYPP) greater than 0.95 are indicated above the nodes. Newly added strains are in blue and ex-type strains are in bold. The tree is rooted to Bipolaris maydis (CBS13629P) and B. panici-miliacei (CBS 19929). Isolated substrates/ habitat is indicated in triangles. Black: Human/ animal, green: plants, brown: soil, pink: air, blue: aquatic habitat. unknown:empty