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Fig. 3 in Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Fig. 3. Effects of test compounds (from Clutia lanceoleta) on the glucose-triggered secretion of insulin from murine islets. Islets were incubated for 1 h at 37 °C in KRB buffer containing glucose (16.7 mM) in the absence (Control) or presence of test compounds and the secreted insulin was measured. Values are mean ± SD from three independent experiments. *P <0.05, **P <0.01, ***P <0.001 compared with the control value.

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Fig. 2. X-Ray crystal structures determined for 1,8,9,11,12,14–17,19,20 in Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Fig. 2. X-Ray crystal structures determined for 1,8,9,11,12,14–17,19,20. Atoms are shown as thermal ellipsoids drawn at the 50% probability level.

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Fig. 1 in Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Fig. 1. Structures of 5-methylcoumarins isolated from Clutia lanceolata. Compounds 1–13 are undescribed, whereas 14–21 are known but are isolated from this plant for the first time. Also shown is the chemical numbering scheme for the ring and its substituents.

Fig. 7 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

Fig. 7. Effect of BIAs 1 and 6 on LPS-stimulated NO (A), IL-6 (B) and TNF-α (C) production in RAW 264.7 macrophages. DXM was used as a positive control at 30 μM concentration. The values are presented as mean SD of triplicate replicates. Statically significant difference was determined by ANOVA and Tukey test (#p <0.05, ± compared with control group, *p<0.05, compared with model group).

Fig. 1 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

Fig. 1. (A) Total ion chromatogram of the extract of M. cochinchinensis. (B) UV absorption bands of compounds 1–3. (C) HRESIMS data of melokhanines KM (1–3).

Fig. 6 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

Fig. 6. Key HMBC (single arrows in red), 1 H– 1 H COSY (bold in blue) and ROESY (double-headed arrows in red) correlations of BIA 3. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 3 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

Fig. 3. Key HMBC (single arrows in red), 1H–1H COSY (bold in blue) and ROESY (double-headed arrows in red) correlations of BIA 1. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 5 in HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

Fig. 5. Key HMBC (single arrows in red), 1H–1H COSY (bold in blue) and ROESY (double-headed arrows in red) correlations of BIA 2. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 5 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines

Fig. 5. The apoptosis rate of compound 1 in HGC-27 cells. (A) The pro-apoptotic effect of compound 1 in HGC-27 cells was analyzed by flow cytometry. (B) Apoptosis rates of the control group and drug groups. Compound 1 treatment at 3.13, 6.25, 12.5, and 25 μM resulted in a significant increase in apoptosis rates in HGC-27 cells. Data are shown as mean ± SD of three independent experiments. *P <0.05 vs. untreated control.

Fig. 4 in Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines

Fig. 4. The pro-apoptotic effect of compound 1 on HGC-27 cells. The cells were treated with different concentrations of 1 for 48 h and visualized for apoptotic bodies under fluorescent microscopy after staining with Hoechst 33,258.

Fig. 4 in The racemic trimeric quinone and polycyclic quinones isolated from the aerial parts of Morinda umbellata L

Fig. 4. Experimental ECD spectra obtained in MeOH and calculated ECD spectra for isomers 1–4 (a–d, respectively).

Fig. 2 in The racemic trimeric quinone and polycyclic quinones isolated from the aerial parts of Morinda umbellata L

Fig. 2. Chiral HPLC-UV chromatogram of racemic 1–4 (a–d) using a Chiralpak AD-H column (4.6 mm × 250 mm, 5 μm); isocratic elution with n-hexane/EtOH (6:4, v/v), flow rate 1.0 mL/min, UV detection at 254 nm, temperature at 25 ◦ C.

Fig. 10 in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 10. Docking of compound 4 to the energy minimized human neutrophil collagenase (MMP-8) showing the binding of the compound within the S1 binding pocket of the active site and H-bonding with Glu219, Gln186 and Ala182.

Fig. 11. Superimposed structures for the docked compound 4 in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 11. Superimposed structures for the docked compound 4 and VLB to the α and β subunit of tubulin. Compound 4 showed a different binding pocket at the interface between α and β subunit from the reference compound VLB.

Fig. 12 in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 12. Structure of topoisomerase-1-DNA complex (top1-DNA complex) with the inhibitor camptothecin (EHD) superimposed to the docked structure with compound 4, showing the interaction of compound 4 with the amino acid residues of top1 (Lys720, Arg708, Asn711 and Arg634) and DNA base pair (DA).

Fig. 9 in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 9. Antioxidant activity of epicatechin (13S) (A) in a DPPH assay compared to the standard trolox (B).

Fig. 5 in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 5. ORTEP-like view of compound 5. Only asymmtric carbon atoms were labelled, the absolute configuration is C1 R, C8 R, C13 R, C14 R, C15 S, C22 S, C23 R, C25 S, C26 R and C27 S.

Fig. 4 in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 4. Separated ORTEP-like view of the absolute configuration of 1 (A) and 3 (B), only asymmetric carbon atoms are labelled.

Fig. 2. 1H–1H in Three phragmalin-type limonoids orthoesters and the structure of odoratone isolated from the bark of Entandrophragma candollei (Meliaceae)

Fig. 2. 1H–1H COSY, selected HMBC correlations (A) and key NOESY correlations (B) of encandollens C and E (1 and 3)

Fig. 4 in The isolation, structure and fragmentation characteristics of natural truxillic and truxinic acid derivatives in Abrus mollis leaves

Fig. 4. Plausible MS/MS fragment ion structures of truxillate forms (1, 5–7) and their precursors (9, 10) during the fragmentation process in negative and positive ion mode. It showed that the main fragmentation pattern of truxillate configurations was symmetric dissociation.