Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
233
datasets available to search
ShareScore release 0.9.0
Dataset results
233 results for “Diastole”
Imaging Assessment of Diastolic Function
ClinicalTrials.gov study NCT01668264. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
ClinicalTrials.gov study NCT04549298. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients
ClinicalTrials.gov study NCT00477789. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Enhancement of Physical Activity in Elderly Patients With Diastolic Heart Failure by a Motivational Intervention
ClinicalTrials.gov study NCT03402490. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Frequency of Asymptomatic Left Ventricular Diastolic Dysfunction in Diabetes Mellitus Type 2
ClinicalTrials.gov study NCT03196687. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure
ClinicalTrials.gov study NCT01411735. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Cross-sectional Study on the Impact of Shift Work on Diastolic Dysfunction in Healthcare Workers
ClinicalTrials.gov study NCT07331233. IPD Sharing: YES. Countries: 0. Publications: 0.
Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart
ClinicalTrials.gov study NCT01944384. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Genomic editing of pathogenic TNNI3 mutation in restrictive cardiomyopathy rescues diastolic dysfunction of human induced pluripotent stem cell-derived cardiomyocytes
GEO Series GSE240775. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction
GEO Series GSE209549. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
The Relation Between Serum Level of Amioterminal Propeptide of Type I Procollagen and Diastolic Dysfunction in Hypertensive Patients Without Diabetes Mellitus
ClinicalTrials.gov study NCT00172406. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Dataset related to article: "Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study"
<p>We provide the raw data used for the following article:</p> <ul> <li>Scotti C, Porta R, Olivares A, Comini L, Cinelli A, Scalvini S, Vitacca M.<br> <em>Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study.</em><br> "J Clin Med." 2020 Jan 7;9(1):162. doi: 10.3390/jcm9010162. PMID: 31936097; PMCID: PMC7019852.</li> </ul> <p> </p> <p><strong>Abstract</strong><br> Obstructive sleep apnea (OSA), although a growing healthcare problem and documented risk factor for cardiovascular diseases, is still under-diagnosed in cardiac patients. To investigate the correlation between OSA and echocardiographic parameters of right ventricle diastolic (RVD) dysfunction, in particular trans-tricuspid E-wave deceleration time (EDT), we retrospectively analyzed data of 103 pure (comorbidity-free) OSA patients with comprehensive echocardiographic examination (ETT). Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean nighttime oxyhemoglobin saturation (SpO2), time elapsed with SpO2 < 90% (T90) and mean peak desaturation of nocturnal events (Mdes, graded as mild, medium or severe) were compared with echocardiographic parameters. We found RVD dysfunction present in 58.3% of patients. Altered EDT correlated significantly with mean SpO2, T90, and Mdes (p < 0.01, all). Nocturnal desaturators had a significantly worse EDT than non-desaturators (p = 0.027) and a higher risk of prolonged EDT (odds ratio, OR = 2.86). EDT differed significantly according to Mdes severity (p = 0.005) with a higher risk of prolonged EDT in medium/severe vs. mild Mdes (OR = 3.44). EDT detected the presence of RVD dysfunction in 58.3% of our pure OSA patients. It correlated poorly with AHI severity but strongly with nocturnal desaturation severity, independently of age. This ETT marker may be useful for deciding appropriate diagnostic and therapeutic strategies.</p>
Nocturnal hypoxia indexes are associated with left ventricular remodeling and diastolic dysfunction in obstructive sleep apnea patients
<p><strong>Background and objective: </strong>Obstructive sleep apnea (OSA) is associated with heart derangements detected at echocardiography as higher left ventricular mass index (LVMI), higher left ventricular end-diastolic diameter, lower left ventricular ejection fraction (LVEF), and impaired diastolic function. However, the currently used parameter to define OSA diagnosis and severity, the apnea/hypopnea index (AHI), poorly predicts cardiovascular damage, cardiovascular events, and mortality. Our study aimed to assess if other polygraphic indices of OSA presence and severity, in addition to AHI, might better predict echocardiographic cardiac remodeling.</p> <p><strong>Methods and results: </strong>We enrolled two cohorts of individuals referred for suspected OSA to the outpatient facilities of the IRCCS Istituto Auxologico Italiano, Milano, and of the Clinica Medica 3, Padova. All patients underwent home sleep apnea testing and echocardiography. Based on the AHI the cohort was divided into no-OSA (AHI<15 events/hour) and moderate-severe OSA (AHI≥15 events/hour). We recruited 162 patients and found that compared to patients with no-OSA, those with moderate-severe OSA showed higher LV remodeling [left ventricular end-diastolic volume (LVEDV) 48.4 ± 11.5 ml/m2 vs. 54.1 ± 14.0 ml/m2, respectively, p = 0.005] and lower LVEF (65.3 ± 5.8% vs. 61.6 ± 7.8%, respectively, p = 0.002), whereas we could not find any difference in LVMI and early and late ventricular filling velocity ratio (E/A). At multivariate linear regression analysis two polygraphic hypoxic burden-related markers were independent predictors of LVEDV and E/A, i.e., the percentage of time with O2 saturation below 90% (β = 0.222) and ODI (β = -0.422), respectively.</p> <p><strong>Conclusions: </strong>Our study shows that nocturnal hypoxia-related indexes were associated with left ventricular remodeling and diastolic dysfunction in OSA patients.</p> <p><strong>Keywords: </strong>Apnea/hypopnea index; Echocardiography; Hypoxia index; Hypoxic burden; Obstructive sleep apnea.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.