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33,754 results for “Enhancers”
Original datasets for : A computational homogenization framework with enhanced localization criterion for macroscopic cohesive failure in heterogeneous materials
<p>The original datasets from tests in the article: <strong> A computational homogenization framework with enhanced localization criterion for macroscopic cohesive failure in heterogeneous materials</strong>. The results are produced by the in-house fem codes of the Computational Mechanics group, CiTG, TU delft.</p>
Spin-mixing enhanced proximity effect in aluminum-based superconductor-semiconductor hybrids
<p>In superconducting quantum circuits, aluminum is one of the most widely used materials. It is currently also the superconductor of choice for the development of topological qubits. In this application, however, aluminum-based devices suffer from poor magnetic field compatibility. In this article, we resolve this limitation by showing that adatoms of heavy elements (e.g. platinum) increase the critical field of thin aluminum films by more than a factor of two. Using tunnel junctions, we show that the increased field resilience originates from spin-orbit scattering introduced by Pt. We exploit this property in the context of the superconducting proximity effect in semiconductor-superconductor hybrids, where we show that InSb nanowires strongly coupled to Al/Pt films can maintain superconductivity up to 7 T. The two-electron charging effect, a fundamental requirement for topo- logical quantum computation, is shown to be robust against the presence of heavy adatoms. Additionally, we use non-local spectroscopy in a three-terminal geom- etry to probe the bulk of hybrid devices, showing that it remains free of sub-gap states. Finally, we demonstrate that semiconductor states which are proximi- tized by Al/Pt films maintain their ability to Zeeman-split in an applied magnetic field. Combined with the chemical stability and well-known fabrication routes of aluminum, Al/Pt emerges as the natural successor to Al-based systems and is a compelling alternative to other superconductors, whenever high-field resilience is required. </p> <p> </p>
(VIDEOS) Glycosylation as a key for enhancing drug recognition into spike glycoprotein of SARS-CoV-2.
<ul> <li>S1_movie_1. Movie of MD1 trajectory showing the Interaction of ligand TCMDC-124223 (roto-translate phenomenon) on RBD in absence of glycosylations within 50ns of simulation.</li> <li>S2_movie_2. Movie of MD4 trajectory showing the Interaction of ligand TCMDC-133766 (induced fit phenomenon) on the cryptic pocket of NTD in presence of glycosylations within 50ns of simulation.</li> <li>S3_movie_3. Movie of MD2 trajectory showing the Interaction of ligand TCMDC-124223 on RBD in presence of glycosylations within 50ns of simulation.</li> <li>S4_movie_4. Movie of MD3 trajectory showing the Interaction of ligand TCMDC-133766 on the cryptic pocket of NTD in absence of glycosylations within 50ns of simulation.</li> <li>S1_movie_1_v2. Movie of MD1 trajectory showing the Interaction of ligand TCMDC-124223 (roto-translate phenomenon) on RBD in absence of glycosylations within 300ns of simulation.</li> <li>S2_movie_2_v2. Movie of MD4 trajectory showing the Interaction of ligand TCMDC-133766 (induced fit phenomenon) on the cryptic pocket of NTD in presence of glycosylations within 300ns of simulation.</li> <li>S3_movie_3_v2. Movie of MD2 trajectory showing the Interaction of ligand TCMDC-124223 on RBD in presence of glycosylations within 300ns of simulation.</li> <li>S4_movie_4_v2. Movie of MD3 trajectory showing the Interaction of ligand TCMDC-133766 on the cryptic pocket of NTD in absence of glycosylations within 300ns of simulation.</li> </ul>
In vivo screening for functional HIF2A enhancers in renal carcinoma.
<p>High throughput sequencing data and analysis from a CRISPRi-based in vivo functional screen for oncogenic HIF2A-bound transcriptional enhancers in renal cancer. </p>
Correlation spectroscopy with multi-qubit-enhanced phase estimation: data
<p>This directory contains the data shown in Figures 2-8 of the paper "Correlation spectroscopy with multi-qubit-enhanced phase estimation" (https://doi.org/10.48550/arXiv.2203.12656). Each data set is stored as matlab .mat file containing variables described in the accompagnying .text document</p>
Replication data for: Enhancing user awareness on inferences obtained from fitness trackers data
<p>Survey results and fitness trackers datasets used for the evaluation of PrivacyEnhAction application.</p>
Data from: Let's stick together: infection enhances preferences for social settings in a songbird species
<p>Acute infections can alter foraging and movement behaviours relevant to sociality and pathogen spread. However, few studies have examined how infection with directly-transmitted pathogens influences host social preferences. Juvenile house finches are gregarious and particularly susceptible to infection by the bacterial pathogen <em>Mycoplasma gallisepticum</em> (MG). Changes in sociality during infection are likely to have important consequences for MG transmission throughout majority-juvenile flocks, but it remains unknown how infection influences sociality in house finches. To test this, we inoculated 33 wild-caught juvenile house finches with MG or media (sham control). At peak infection, birds were given a choice assay to assess preference for associating near a flock versus an empty cage. Infected birds were significantly more likely than controls to spend time near the flock while eating, and marginally so while perching. These results indicate augmented social preferences during infection, potentially as a form of behavioural tolerance. Notably, infected birds showed strong social preferences regardless of individual variation in disease severity or pathogen loads, with 14/19 harbouring high loads (log10 5-6) at time of assay. Overall, our results show that infection with a directly-transmitted pathogen can augment social preferences, with potential implications for MG spread in natural populations.</p>
GPS Location Spoofing Attack Detection for Enhancing the Security of Autonomous Vehicles (presentation video)
<p>Video of the presentation for the publication M. Kamal, A. Barua, C. Vitale, C. Laoudias and G. Ellinas, "GPS Location Spoofing Attack Detection for Enhancing the Security of Autonomous Vehicles," 2021 IEEE 94th Vehicular Technology Conference (VTC2021-Fall), 2021, pp. 1-7, doi: 10.1109/VTC2021-Fall52928.2021.9625567.</p>
Enhancing bioreactor arrays for automated measurements and reactive control with ReacSight
<p>This dataset supports the paper <em>"</em>Enhancing bioreactor arrays for automated measurements and reactive control with ReacSight" (2021). ReacSight is a generic and flexible strategy to enhance bioreactor arrays for automated measurements and reactive experiment control. We used ReacSight to assemble a platform for cytometry-based characterization and reactive optogenetic control of parallel yeast continuous cultures. Using a dedicated bioreactor array, we showcased its capabilities on several applications. This dataset contains all the corresponding raw data. Together with code available in the <a href="https://gitlab.inria.fr/InBio/Public/reacsight">ReacSight git repository</a>, it allows to reproduce the analysis of raw data and the generation of the figures appearing in the paper.</p>
Data and analysis scripts of "Predictability awareness rather than mere predictability enhances the perceptual benefits for targets in auditory rhythms over targets following temporal cues"
<p>These are the data and the analysis scripts accompanying the publication </p> <p>"Predictability awareness rather than mere predictability enhances the perceptual benefits for targets in auditory rhythms over targets following temporal cues". </p> <p>Check the readMe for an instruction.</p>
Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate
<p>Astrocytes perform critical functions in the nervous system, many of which are dependent on neurotransmitter-sensing through G protein-coupled receptors (GPCRs). However, whether specific astrocytic outputs follow specific GPCR activity remains unclear, and exploring this question is critical for understanding how astrocytes ultimately influence brain function and behavior. Here, we investigate the outputs of astrocytic Gi-GPCRs, a family of GPCRs which we previously showed is sufficient to increase slow-wave neural activity (SWA) during sleep when activated in cortical astrocytes<sup>1</sup>. We focus on two putative outputs by astrocytes <em>in vivo</em>, the regulation of extracellular glutamate and GABA, by combining fiber photometry recordings of the extracellular indicators iGluSnFR and iGABASnFR with astrocyte-specific chemogenetic Gi-GPCR activation. We find that Gi-GPCR activation does not change spontaneous dynamics of extracellular glutamate or GABA. However, Gi-GPCR activation does specifically increase visual stimulus-evoked extracellular glutamate. Together, these data point towards a complex relationship between astrocytic inputs and outputs <em>in vivo </em>that may depend on behavioral context. Further, they suggest an extracellular glutamate-specific mechanism underlying some astrocytic Gi-GPCR-dependent behaviors, including the regulation of sleep SWA.</p>
A Database for Reasearch on Detection and Enhancement of Speech transmitted over HF links
<p>We present an open database for the development of detection and enhancement algorithms of speech transmitted over HF radio channels.<br> It consists of audio samples recorded by various receivers at different locations across Europe, all monitoring the same single-sideband modulated transmission from a base station in Paderborn, Germany. Transmitted and received speech signals are precisely time aligned to offer parallel data for supervised training of deep learning based detection and enhancement algorithms.</p>
Data for: Red foxes enhance long-term tree growth near the Arctic treeline
<p>Recent climate warming is expected to increase tree growth and productivity, substantially altering ecological function and boundaries in northern ecosystems. Temperature and precipitation largely determine the range and growth of trees in any biome, yet variations in microsite conditions can also influence tree growth on a finer scale. By altering essential resources and habitat conditions, terrestrial organisms could modify Subarctic tree growth. Red foxes (<em>Vulpes vulpes</em>) are found in most terrestrial ecosystems and are considered ecosystem engineers by enriching soil nutrients and plant composition through denning. Added soil nutrients from prey remains, feces, and urine could benefit tree growth in Subarctic regions by alleviating soil nutrient limitations. We examined growth in white spruce (<em>Picea glauca</em>) trees growing on eight red fox dens and paired control sites near Churchill, Manitoba, Canada, at the Arctic treeline. Radial growth was 55% higher for trees on dens than on control sites between 1897 and 2017, despite similarities in tree ages, densities, and regional climate across all sites. By promoting tree growth near the treeline, red foxes may influence the position of the Arctic treeline. Although the impacts on tree growth largely depend on the spatial distribution of dens and predator activity in the boreal forest, predators can create distinct microhabitats across the landscape via ecosystem engineering processes, leading to increased vegetation productivity, persisting over many decades.</p>
Carbon Nanotube Uptake in Cyanobacteria for Near-infrared Imaging and Enhancing Bioelectricity Generation in Living Photovoltaics
<p>Dataset of the work entitled "Carbon Nanotube Uptake in Cyanobacteria for Near-infrared Imaging and Enhancing Bioelectricity Generation in Living Photovoltaics".</p>
Supplement to: Enhanced surveillance of monkeypox in Bas-Uélé, Democratic Republic of Congo: the limitations of symptom-based case definitions
<p>This repository contains data and R code which are supplements to:</p> <p><em>Enhanced surveillance of monkeypox in Bas-Uélé, Democratic Republic of Congo: the limitations of symptom-based case definitions</em><br> Gaspard Mande, Innocent Akonda, Anja De Weggheleire, Isabel Brosius, Laurens Liesenborghs, Emmanuel Bottieau, Noam Ross, Guy Crispin Gembue, Robert Colebunders, Erik Verheyen Ngonda Daulya, Herwig Leirsh, and Anne Laudisoit (2022).</p> <p>A data dictionary and instructions for reproducing the analysis are provided. Details can be found in the README.md file.</p>
Low water availability enhances volatile-mediated direct defenses but disturbs indirect defenses against herbivores
<p>1. Interactions between plants and natural enemies of insect herbivores influence plant productivity and survival by reducing herbivory. Plants attract natural enemies via herbivore-induced plant volatiles (HIPVs), but how water availability (WA) influences HIPV-mediated defenses is unclear. </p> <p>2. We use tomato (<em>Solanum lycopersicum</em>), tomato fruitworm (<em>Helicoverpa zea</em>), and two natural enemies, the parasitoid wasp (<em>Microplitis croceipes</em>) and the predator spined soldier bug (<em>Podisus maculiventris</em>), to investigate the effect of WA on HIPV emission dynamics and associated plant defense. </p> <p>3. We show that low WA initially increases total HIPV emission by tomatoes on the first day of herbivore exposure and, in contrast, reduces HIPV emission on the second day. Low WA enhances HIPVs that are mostly found in tomato trichomes. Notably, some volatiles inhibited by low WA are known attractants of natural enemies. Evidence from Y-tube and in-cage behavioral assays indicates that changes in HIPV emissions by low WA compromise the ability of tomato plants to attract natural enemies. </p> <p>4. Synthesis: Based on our results, we propose a hypothesis where plants respond to low WA by enhancing repellent HIPV emissions and reducing the emission of HIPVs that attract natural enemies, which disrupts natural enemy-mediated plant indirect defenses but enhances plant direct defense against herbivores.</p>
Data from: Network-based biostratigraphy for the late Permian to mid-Triassic Beaufort Group (Karoo Supergroup) in South Africa enhances biozone applicability and stratigraphic correlation
<p>The Permo-Triassic vertebrate assemblage zones (AZs) of South Africa's Karoo Basin are a standard for local and global correlations. However, temporal, geographical, and methodological limitations challenge the AZs reliability. We analyze a unique fossil dataset comprising 1408 occurrences of 115 species grouped into 19 stratigraphic bin intervals from the <em>Cistecephalus</em>, <em>Daptocephalus</em>, <em>Lystrosaurus</em> <em>declivis</em>, and <em>Cynognathus</em> AZs. Using network science tools we compare six frameworks: Broom, Rubidge, Viglietti, Member, Formation, including a framework suggesting diachroneity of the <em>Daptocephalus</em>/<em>Lystrosaurus</em> AZ boundary (Gastaldo). Our results demonstrate that historical frameworks (Broom, Rubidge) still identify the Karoo AZs. No scheme supports the <em>Cistecephalus</em> AZ, and it likely comprises two discrete communities. The <em>Lystrosaurus</em> <em>declivis</em> AZ is traced across all frameworks, despite many shared species with the underlying <em>Daptocephalus</em> AZ, suggesting the extinction event across this interval is not a statistical artifact. A community shift at the upper Katberg to lower Burgersdorp formations may indicate a depositional hiatus, which has important implications for regional correlations and Mesozoic ecosystem evolution. The Gastaldo model still identifies a <em>Lystrosaurus</em> and <em>Daptocephalus</em> AZ community shift, does not significantly improve recent AZ models (Viglietti), and highlights important issues with some AZ studies. Localized bed-scale lithostratigraphy (sandstone datums), and singleton fossils cannot be used to reject the patterns shown by hundreds of fossils, and regional chronostratigraphic markers of the Karoo foreland basin. Meter-level occurrence data suggest that 20–50 m sampling intervals capture Karoo AZs, unifying the use of meter-level placements of singleton fossils to delineate biozone boundaries and make regional correlations.</p>
Data from: Differential gene expression during recall of behaviorally conditioned immune enhancement in rats: a pilot study
<p><strong>Background:</strong> Behaviorally conditioned immune functions are suggested to be regulated by bidirectional interactions between CNS and peripheral immune system <em>via</em> the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic nervous system (SNS), and the parasympathetic nervous system (PNS). Since the current knowledge about biochemical pathways triggering conditioned immune enhancement is limited, the aim of this pilot study was gaining more insights into that.</p> <p><strong>Methods: </strong>Rats were conditioned with camphor smell and poly I:C injection, mimicking a viral infection. Following stimulus re-exposure, animals were sacrificed at different time points, and neural tissues along the HPA axis was analyzed with a rat genome array together with plasma protein using Luminex analysis.</p> <p><strong>Results:</strong> In the hypothalamus, we observed a strong upregulation of genes related to Wnt/β-catenin signaling (Otx2, Spp1, Fzd6, Zic1), monoaminergic transporter Slc18a2 and opioid-inhibitory G-protein Gpr88 as well as downregulation of dopaminergic receptors, vasoactive intestinal peptide Vip, and pro-melanin-concentrating hormone Pmch. In the pituitary, we recognized mostly upregulation of steroid synthesis in combination with GABAergic, cholinergic and opioid related neurotransmission, in adrenal glands, altered genes showed a pattern of activated metabolism plus upregulation of adrenoceptors Adrb3 and Adra1a. Data obtained from spleen showed a strong upregulation of immunomodulatory genes, chemo-/cytokines and glutamatergic/cholinergic neurotransmission related genes, as also confirmed by increased chemokine and ACTH levels in plasma.</p> <p><strong>Conclusions:</strong> Our data indicate that in addition to the classic HPA axis, there could be additional pathways as e.g. the cholinergic anti-inflammatory pathway (CAIP), connecting brain and immune system, modulating and finetuning communication between brain and immune system.</p>
Coherent enhancement of optical remission in diffusive media
<p>Experimental data sets associated with "Coherent enhancement of optical remission in diffusive media" (https://doi.org/10.1073/pnas.2207089119).</p>
Genome of the isolates: Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities
<p>The draft genome of the isolates in Mouse Intestinal Bacteria Collection (miBC)</p> <p> </p> <p>Microbiome research is hampered by the fact that many bacteria are still unknown and by the lack of publicly available isolates. Fundamental and clinical research is in need of comprehensive and well-curated repositories of cultured bacteria from the intestine of mammalian hosts. Due to host-specific features of the gut microbiota, it is sound to establish collections of isolates from single host species. Hence, this project established a collection of bacterial strains isolated from the intestine of mice.</p> <p>The original version of the collection published in 2016 (Lagkouvardos, et. al. 2016.<em> Nat. Microbiol.</em>). was doubled by the addition of 112 strains, representing a total of 141 species across 6 phyla and 35 families for the entire collection. As we aimed to create a well-curated resource, all bacterial species within miBC have been taxonomically described and are publicly available.</p> <p> </p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.