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509 results for “Hepatitis C Virus”
PERVASIVE ADAPTATION OF HEPATITIS C VIRUS TO INTERFERON LAMBDA POLYMORPHISM ACROSS MULTIPLE GENOTYPES
<p>Genetic polymorphism in the interferon lambda (IFN-λ) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and with response to interferon-based antiviral treatment. Here, we evaluate the associations between IFN-λ polymorphism and HCV variation by performing a genome-to-genome analysis in 8,729 patients from diverse ancestral backgrounds infected with various HCV genotypes. We searched for associations between human rs12979860 genotype, a tag for IFN-λ haplotypes, and amino acid variants in the NS3, NS4A, NS5A and NS5B proteins of HCV. We report multiple associations between host and pathogen variants in the full cohort as well as in subgroups defined by viral genotype and human ancestry. We also assess the combined impact of human and HCV variation on pre-treatment viral load. By demonstrating that IFN-λ genetic variation leaves a large footprint in the viral genome, this study provides strong evidence of pervasive viral adaptation to host innate immune pressure during chronic HCV infection.</p>
A Single Ascending Dose Study of Daclatasvir (BMS-790052) in Hepatitis C Virus Infected Subjects
ClinicalTrials.gov study NCT00546715. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune Response to Hepatitis C Virus
ClinicalTrials.gov study NCT00165919. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Elimination of Hepatitis C Virus Among Users of Substances
ClinicalTrials.gov study NCT05503979. IPD Sharing: YES. Countries: 0. Publications: 5.
Determining the Sustained Virologic Response of Declatasvir in Egyptian Patients With Hepatitis C Virus Genotype 4
ClinicalTrials.gov study NCT02772744. IPD Sharing: UNDECIDED. Countries: 0. Publications: 3.
Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) Infection
ClinicalTrials.gov study NCT03074331. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Oral Doses of BI 201335 as Softgel Capsule in Naive Hepatitis C Virus (HCV) Patients
ClinicalTrials.gov study NCT00947349. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Erythropoietic Response in Hepatitis C Virus (HCV) Patients Receiving Combination Ribavirin (RBV)/Interferon (IFN) Therapy or RBV/PEG IFN (NATURAL HISTORY-HCV)
ClinicalTrials.gov study NCT00328549. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Sofosbuvir/Velpatasvir Fixed-Dose Combination and Ribavirin for 12 or 24 Weeks in Participants With Chronic Genotype 1 or 2 Hepatitis C Virus Infection Who Have Previously Failed a Direct-Acting Antiv
ClinicalTrials.gov study NCT02822794. IPD Sharing: YES. Countries: 1. Publications: 0.
Improving Response to Immunotherapy in Patients With Advanced Hepatocellular Carcinoma and Chronic Hepatitis C Virus Infection With Direct-Acting Antiviral Therapy
ClinicalTrials.gov study NCT05717400. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety Study of Simeprevir in Combination With Sofosbuvir in Participants With Genotype 1 Chronic Hepatitis C Virus Infection and Cirrhosis
ClinicalTrials.gov study NCT02114151. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study to Treat Subjects With Telaprevir, Ribavirin, and Peginterferon Who Are Coinfected With HIV and Hepatitis C Virus (HCV)
ClinicalTrials.gov study NCT01467479. IPD Sharing: Not stated. Countries: 5. Publications: 0.
NATURAL HISTORY-Hepatitis C Virus/ Human Immunodeficiency Virus Coinfection
ClinicalTrials.gov study NCT00315432. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Study of TMC435 in Participants With Genotype 1 Hepatitis C Virus (HCV) Infection
ClinicalTrials.gov study NCT01366638. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Armodafinil for Patients Starting Hepatitis C Virus Treatment
ClinicalTrials.gov study NCT01470651. IPD Sharing: NO. Countries: 1. Publications: 0.
Study Comparing Daclatasvir (BMS-790052) With Telaprevir Combined With Peginterferon Alfa-2a and Ribavirin in Patients With Chronic Hepatitis C Virus Infection
ClinicalTrials.gov study NCT01492426. IPD Sharing: Not stated. Countries: 16. Publications: 0.
Chronic Hepatitis C Virus Related Thrombocytopenia to Evaluate the Effects of E5501
ClinicalTrials.gov study NCT01355289. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of CTS-1027 in Combination With Pegylated Interferon and Ribavirin in Hepatitis C Virus (HCV) Null-Responders
ClinicalTrials.gov study NCT01051921. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Study of Hepatitis C Virus (HCV) Viral Kinetics in HIV/HCV and HCV Patients
ClinicalTrials.gov study NCT00703560. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Pegylated Interferon, Ribavirin, Telaprevir in Hepatitis C Virus Infection in Orthotopic Liver Transplant Recipients
ClinicalTrials.gov study NCT01592006. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.