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2,435 results for “Metastasis”
Vaccine Therapy and Radiation to Liver Metastasis in Patients With CEA-Positive Solid Tumors
ClinicalTrials.gov study NCT00081848. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary
ClinicalTrials.gov study NCT02429570. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis
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Over-expression of Ki-67 as a predictor of lymph node metastasis in penile cancer patients
<p>In this study, we will look at the association of Ki-67 with lymph node metastasis in patients with penile cancer.</p>
Dataset related to article "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis."
<p>The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell-mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell-mediated resistance to metastasis.</p>
Data from: iTRAQ-based quantitative proteomic analysis on S100 calcium binding protein A2 in metastasis of laryngeal cancer
Laryngeal cancer is the most frequent neoplasm in the head and neck region, with the vast majority of tumors originating from squamous cells. The survival rate of patients with laryngeal cancer has not improved substantially over the past 25 years. To acquire further knowledge regarding the molecules responsible for laryngeal cancer oncogenesis and, in turn, to improve target therapy,iTRAQ and mass spectrometry analysis were utilized to detect differences in protein expression from 15 paired laryngeal cancer and adjacent non-cancerous tissue samples. Using mass spectrometry analysis, the expression levels of 100 proteins in laryngeal cancer samples were distinct from the non-tumor, non-cancerous samples. Further validation of the differentially expressed proteins S100A2, KRT16, FGB and HSPB1 were carried out using quantitative real-time RT-PCR, immunoblot and immunohistochemistry. Functional analysis of one of the highly expressed proteins, S100 calcium binding protein A2 (S100A2), was performed using RNA interference. As a consequence, attenuated S100A2 expression enhanced the ability of HEp-2 cell lines to migrate and invade in vitro. Our investigation complements the current understanding of laryngeal cancer progression. Furthermore, this study supports the concept that enhanced expression of S100A2 may be a promising strategy in developing novel cancer therapeutic drugs.
Prostate Cancer Metastasis Cardiometabolic Diseases Dataset, Meta-Analysis & Systematic Review
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Single-cell RNA-seq dataset and code for human colorectal cancer liver metastasis study
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Dataset related to article: "Heme catabolism by tumor-associated macrophages controls metastasis formation"
<p>This record contains raw data related to article "Heme catabolism by tumor-associated macrophages controls metastasis formation"</p> <p> </p> <p>Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct subset of TAMs (F4/80<sup>hi</sup>CD115<sup>hi</sup>C3aR<sup>hi</sup>CD88<sup>hi</sup>), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. This population originates from F4/80<sup>+</sup>HO-1<sup>+</sup> bone marrow (BM) precursors, accumulates in the blood of tumor bearers and preferentially localizes at the invasive margin through a mechanism dependent on the activation of Nrf2 and coordinated by the NF-κB1-CSF1R-C3aR axis. Inhibition of F4/80<sup>+</sup>HO-1<sup>+</sup> TAM recruitment or myeloid-specific deletion of HO-1 blocks metastasis formation and improves anticancer immunotherapy. Relative expression of HO-1 in peripheral monocyte subsets, as well as in tumor lesions, discriminates survival among metastatic melanoma patients. Overall, these results identify a distinct cancer-induced HO-1<sup>+</sup> myeloid subgroup as a new antimetastatic target and prognostic blood marker.</p>
A critical review of uterine leiomyoma with subsequent recurrence or metastasis: A multicenter study of 62 cases
<p><strong>Aim</strong>: Histopathologic diagnosis of a subset of uterine smooth muscle tumors is challenging. We report a critical review regarding the clinicopathological point of view of 62 cases of subsequently recurred or metastasized leiomyoma.</p> <p><strong>Methods</strong>: Medical records and glass slides of 62 cases of uterine smooth muscle tumor diagnosed as leiomyoma, which subsequently recurred or metastasized, were critically reviewed by pathologists specializing in gynecologic pathology and oncology. </p> <p><strong>Results</strong>: In 47 (75.8%) of 62 cases, the diagnosis of leiomyoma was confirmed, including 11 intravascular leiomyomatosis (IVL) and benign metastasizing leiomyoma (BML). In 29 cases (46.8%) laparoscopic surgery was performed, of which morcellator without a bag was employed in 23 cases. Fifteen cases (24.2%) appeared to be underestimated and were re-classified as smooth muscle tumor of uncertain malignant potential (STUMP), leiomyosarcoma, or other malignant mesenchymal tumors. Recurrences in 7 cases (11.3%) were interpreted to be a malignant transformation, and one Smooth muscle tumor of uncertain malignant potential (STUMP) recurred as STUMP. </p> <p><strong>Conclusion</strong>: The recurrence or metastasis in cases of "leiomyoma" is attributed to iatrogenic or under-evaluation of primary tumors, although a subset of cases is a rare example of biological progression.</p>
Understanding tumor heterogeneity in melanoma brain metastasis using spatial transcriptomics and multi-regional bulk sequencing
<p>Melanoma brain metastasis (MBM) exhibits extensive inter- and intra-tumor heterogeneity, driven by a complex tumor microenvironment (TME). The aim with this study was to profile the MBMs by using a multi-omics approach, integrating spatial transcriptomics with bulk exome, proteome, and transcriptome profiling. We identified significant patient-specific variations in immune cell infiltration, particularly in B/plasma cells, myeloid cells, and cancer-associated fibroblasts (CAFs). Notably, immunotherapy-treated patients showed enrichedpathways related to EMT, IFN-γ signaling, oxidative phosphorylation, T-cell signaling, inflammation and DNA damage, which aligned with distinct cellular compositions observed in the spatial analysis. We also uncovered considerable intra-tumor heterogeneity, especially at the protein level, revealing differential expression patterns of key tumor and immune-related markers. The correlation between mRNA and protein data highlighted consistent enrichment of critical pathways across multi-omics layers. These findings provide a comprehensive view of MBM's molecular and cellular landscape, emphasizing the importance of addressing tumor heterogeneity in developing effective therapeutic strategies.</p>
Association of lymph node metastasis of hepatocellular carcinoma with the gut microbiota, bile acid metabolism, and MIP-1α
<p>Supplementary figures for the manuscript.</p>
Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial Metastasis
ClinicalTrials.gov study NCT04870645. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT02480634. IPD Sharing: Not stated. Countries: 0. Publications: 31.
MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
ClinicalTrials.gov study NCT02669914. IPD Sharing: NO. Countries: 1. Publications: 0.
Short Versus Long Intramedullary Nails in the Treatment of Proximal Femur Metastasis.
ClinicalTrials.gov study NCT05969470. IPD Sharing: NO. Countries: 0. Publications: 1.
Prediction of Axillary Lymph Node Metastasis Status in Breast Cancer Based on PET/CT Radiomics
ClinicalTrials.gov study NCT05826197. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Phase II Trial of Stereotactic Radiation Therapy (SRT) Versus SRT Plus Vertebral Augmentation Procedure (VAP) for Vertebral Metastasis
ClinicalTrials.gov study NCT01527292. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Compassionate Same-Day Evaluation & Delivery of XRT for Bony Metastasis in Hospice Patients
ClinicalTrials.gov study NCT01760941. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
ClinicalTrials.gov study NCT02948751. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.