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287 results for “Response to selection”
Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors
GEO Series GSE186467. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Two oppositely-chargedsf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila
GEO Series GSE171002. Drosophila melanogaster. 15 samples. Type: Expression profiling by high throughput sequencing.
Data from: Selection for brain size impairs innate, but not adaptive immune responses
The brain and the immune system are both energetically demanding organs, and when natural selection favors increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over eight days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared to large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.
Data from: Antagonistic responses to natural and sexual selection and the sex-specific evolution of cuticular hydrocarbons in Drosophila simulans
Natural and sexual selection are classically thought to oppose one another, and while there is evidence for this, direct experimental demonstrations of this antagonism are largely lacking. Here we assessed the effects of sexual and natural selection on the evolution of cuticular hydrocarbons (CHCs), a character subject to both modes of selection, in Drosophila simulans. Natural selection and sexual selection were manipulated in a fully factorial design, and after 27 generations of experimental evolution the responses of male and female CHCs were assessed. The effects of natural and sexual selection differed greatly across the sexes. The responses of female CHCs were generally small, but CHCs evolved predominantly in the direction of natural selection. For males, profiles evolved via sexual and natural selection, as well as through the interaction between the two, with some male CHC components only evolving in the direction of natural selection when sexual selection was relaxed. These results indicate sex-specific responses to selection, and that sexual and natural selection act antagonistically for at least some combinations of CHCs.
Data from: Evolution of divergent female mating preference in response to experimental sexual selection
Sexual selection is predicted to drive the coevolution of mating signals and preferences (mating traits) within populations, and could play a role in speciation if sexual isolation arises due to mating trait divergence between populations. However, few studies have demonstrated that differences in mating traits between populations result from sexual selection alone. Experimental evolution is a promising approach to directly examine the action of sexual selection on mating trait divergence among populations. We manipulated the opportunity for sexual selection (low versus high) in populations of Drosophila pseudoobscura. Previous studies on these experimental populations have shown that sexual selection manipulation resulted in the divergence between sexual selection treatments of several courtship song parameters, including IPI (inter-pulse interval) which markedly influences male mating success. Here, we measure female preference for IPI using a playback design to test for preference divergence between the sexual selection treatments after 130 generations of experimental sexual selection. The results suggest that female preference has coevolved with male signal, in opposite directions between the sexual selection treatments, providing direct evidence of the ability of sexual selection to drive the divergent coevolution of mating traits between populations. We discuss the implications in the context sexual selection and speciation.
Data from: Effectiveness of genomic selection by response to selection for winter wheat variety improvement
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Evaluation of selected serum biomarkers levels in response to infliximab reference product (Remicade®) versus it's biosimilar (Remsima®) in a sample of ulcerative colitis patients: a cross-sectional study
<p><strong>Evaluation of selected serum biomarkers levels in response to infliximab reference product (Remicade</strong><sup>®</sup><strong>) versus it's biosimilar (Remsima</strong><sup>®</sup><strong>) in a sample of ulcerative colitis patients: a cross-sectional study</strong></p>
A Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake/Serotonin-Norepinephrine Reuptake Inhibitor Antidepressant
ClinicalTrials.gov study NCT05109195. IPD Sharing: NO. Countries: 2. Publications: 0.
Serologic Response to the SARS-CoV-2 (COVID-19) MRNA-1273 Vaccine in Select Subsets of Oncology Patients
ClinicalTrials.gov study NCT04854980. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Evaluation of Selected Responsible Fatherhood and Healthy Marriage Programs: Parents and Children Together
ClinicalTrials.gov study NCT02056457. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serot
ClinicalTrials.gov study NCT05841030. IPD Sharing: NO. Countries: 11. Publications: 0.
To Test the Effect of Selected Fibres and Flours in Flat Bread on Post-Prandial Blood Glucose and Insulin Responses in Healthy Indian Population
ClinicalTrials.gov study NCT02814357. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial
ClinicalTrials.gov study NCT07288034. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)
ClinicalTrials.gov study NCT06390709. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
ClinicalTrials.gov study NCT06704594. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psych
ClinicalTrials.gov study NCT04951609. IPD Sharing: YES. Countries: 4. Publications: 0.
Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
GEO Series GSE227465. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
Data from: Antagonistic responses to natural and sexual selection and the sex-specific evolution of cuticular hydrocarbons in Drosophila simulans
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Data from: Evolution of divergent female mating preference in response to experimental sexual selection
Open the record for dataset details and reuse information.
Data from: Effectiveness of genomic selection by response to selection for winter wheat variety improvement
Open the record for dataset details and reuse information.
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International Brain Laboratory public data
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OpenNeuro
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