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906 results for “atherosclerosis”
Figure 3 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 3 ACE administration increased the level of regulatory T cells in mice fed a high-fat, high-fructose diet for 5 months. The level of regulatory T cell A. CD4+CD25+CD62L+ subsets, B. CD4+CD25+IL-10+ subsets, and C. CD4+CD25+TGF-+subsets of mice fed with HFFD and administration of ACE from flow cytometry analysis. The percentage of regulatory T cell D. CD4+CD25+CD62L+ subsets, E. CD4+CD25+IL-10+ subsets, and F. CD4+CD25+TGF-+ subsets of mice fed with HFFD and administered ACE The data are mean SD (n = 5). N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/kg body weight; D3: HFFD mice receiving ACE 5200 mg/kg body weight. The different notation on the chart was considered significantly different for each group at p<0.05 and vice versa on the DMRT post hoc test.
Figure 5 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 5 The effect of ACE increased TGF-β production (CD4+TGF-β+) in mice fed with a high fat-fructose diet for 5 months. The expression of TGF-β (CD4+TGF-β+) of mice fed with HFFD and administration of ACE from flow cytometry analysis (Fig. 5G). The percentage of regulatory (CD4+IL-10+) of mice fed with HFFD and administration of ACE (Fig. 5H). Data are mean ± SD (n=5). N: normal fed mice (non-high fat-fructose diet), HFFD: high fat-fructose diet mice (w/o administration of ACE), D1: HFFD mice receiving ACE 104 mg/kg body weight, D2: HFFD mice receiving ACE 520 mg/kg BW, D3: HFFD mice receiving ACE 5200 mg/kg BW. The different notation on the chart was considered significantly different for each group at p < 0.05 and vice versa on DMRT post hoc test.
Figure 2 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 2 ACE administration reduced foam cells in aorta histopathology (M = 400×) in mice fed a high-fat, high-fructose diet for 5 months. The black arrow shows the accumulation of foam cells in the tunica media, and the asterisk (*) shows the lumen of the aorta. N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/kg body weight; D3: HFFD mice receiving ACE 5200 mg/kg body weight.
Figure 1 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 1 Reduction of Lp-PLA2 production after ACE treatment in mice fed a high-fat, high-fructose diet. The expression of Lp-PLA2 production in mice fed with HFFD and administered ACE was determined from flow cytometry analysis (Fig. 1A). The percentage of Lp-PLA2 production in mice fed with HFFD and administered ACE The data are mean SD (n = 5). N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/gram BW; D3: HFFD mice receiving ACE 5200 mg/kg BW. The different notation on the chart was considered significantly different for each group at p< 0.05 and vice versa on the DMRT post hoc test.
Figure 4 from: Nafisah W, Dalilati AZ, Christina YI, Atho'illah MF, Rifa'ia M, Noor TNETA, Nugraha AP (2024) Amstirdam coffee ameliorates Lp-PLA2 and the inflammatory response in an atherosclerosis rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e106817
Figure 4 Administration of ACE increased IL-10 production (CD4+IL-10+) in mice fed with a high-fat, high-fructose diet for 5 months. The expression of CD4+IL-10+ in mice fed with HFFD and administered ACE was determined by flow cytometry analysis (Fig. 4E). The percentage of regulatory cells (CD4+IL-10+) in mice fed with HFFD and administered ACE (Fig. 4F) The data are mean SD (n = 5). N: normal-fed mice (non-high-fat-fructose diet); HFFD: high-fat-fructose diet mice (w/o administration of ACE); D1: HFFD mice receiving ACE 104 mg/kg body weight; D2: HFFD mice receiving ACE 520 mg/kg body weight; D3: HFFD mice receiving ACE 5200 mg/kg body weight. The different notation on the chart was considered significantly different for each group at p < 0.05 and vice versa on the DMRT pos hoc test.
Proteome-wide Mendelian randomization study identifies potential therapeutic targets for Coronary atherosclerosis
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Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis
<p>Background CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes<br> the recruitment of T-lymphocytes and other immune cells to the inflammatory site in response to the binding of cognate<br> chemokines. Upregulation of CXCR3 and its chemokines has been found during atherosclerotic lesion formation.<br> Therefore, detection of CXCR3 by positron emission tomography (PET) radiotracer can be a useful tool for detecting the development of atherosclerosis in a noninvasive manner. Herein, we report the synthesis, radiosynthesis, and characterization of a novel fluorine-18 (F-18, <sup>18</sup>F) labeled small-molecule radiotracer for the imaging of the CXCR3 receptor in mouse models of atherosclerosis.<br> Results The reference standard <strong>1</strong> and its precursor <strong>9</strong> were synthesized over 5 steps from starting materials in good to moderate yields. The measured K<sub>i</sub> values of CXCR3A and CXCR3B were 0.81 ± 0.02 nM and 0.31 ± 0.02 nM, respectively. [<sup>18</sup>F]<strong>1</strong> was prepared by a two-step radiosynthesis with a decay-corrected radiochemical yield of 13 ± 2%, radiochemical purity > 99%, and specific activity of 44.4 ± 3.7 GBq/μmol at the end of synthesis (n = 6). The baseline studies showed that [<sup>18</sup>F]<strong>1</strong> displayed high uptake in the atherosclerotic aorta and brown adipose tissue in Apolipoprotein E (ApoE) knockout (KO) mice fed with a high-fat diet over 12 weeks. The uptake of [<sup>18</sup>F]<strong>1</strong> in these regions was reduced significantly in self-blocking studies, demonstrating CXCR3 binding specificity. Contrary to this, no significant differences in uptake of [<sup>18</sup>F]<strong>1</strong> in the abdominal aorta of C57BL/6 control mice fed with a normal diet were observed in both baseline and blocking studies, indicating increased CXCR3 expression in atherosclerotic lesions. Immunohistochemistry studies demonstrated that [<sup>18</sup>F]<strong>1</strong>-positive regions were correlated with CXCR3 expression, but some<br> atherosclerotic plaques with significant size were not detected by [<sup>18</sup>F]<strong>1</strong>, and their CXCR3 expressions were minimal.<br> Conclusion [<sup>18</sup>F]<strong>1</strong> was synthesized with good radiochemical yield and high radiochemical purity. In PET imaging<br> studies, [<sup>18</sup>F]<strong>1</strong> displayed CXCR3-specific uptake in the atherosclerotic aorta in ApoE KO mice. [<sup>18</sup>F]<strong>1</strong> visualized CXCR3<br> expression in different regions in mice aligned with the tissue histology studies. Taken together, [<sup>18</sup>F]<strong>1</strong> is a potential<br> PET radiotracer for imaging CXCR3 in atherosclerosis.</p>
Potential Role of CMV in Restenosis Following Angioplasty, in Atherosclerosis, and in Endothelial Dysfunction
ClinicalTrials.gov study NCT00001531. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Micro-RNA Profile in Patients With Different Stages of Atherosclerosis According to CTA
ClinicalTrials.gov study NCT03855891. IPD Sharing: NO. Countries: 1. Publications: 0.
CARotid Mri of Atherosclerosis
ClinicalTrials.gov study NCT04835571. IPD Sharing: NO. Countries: 0. Publications: 3.
Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis
ClinicalTrials.gov study NCT00001841. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study
ClinicalTrials.gov study NCT00041444. IPD Sharing: Not stated. Countries: 0. Publications: 30.
Does the Human Gut Microbiome Serve as a Novel Personalized Therapeutic Target for Coronary Atherosclerosis?
ClinicalTrials.gov study NCT03009565. IPD Sharing: Not stated. Countries: 0. Publications: 15.
Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis
ClinicalTrials.gov study NCT00361283. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reducing Intracranial atheroSclErosis With Repatha
ClinicalTrials.gov study NCT04573777. IPD Sharing: NO. Countries: 1. Publications: 0.
Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-On
ClinicalTrials.gov study NCT03597035. IPD Sharing: NO. Countries: 1. Publications: 0.
Homocysteine and Progression of Atherosclerosis
ClinicalTrials.gov study NCT00005338. IPD Sharing: Not stated. Countries: 0. Publications: 21.
Estrogen Replacement and Atherosclerosis (ERA) in Older Women
ClinicalTrials.gov study NCT00000549. IPD Sharing: Not stated. Countries: 0. Publications: 6.
Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)
ClinicalTrials.gov study NCT00552097. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Inturlekin L33 in Ankylosing Spondylities Patients and Its Relation to Subclinical Atherosclerosis
ClinicalTrials.gov study NCT06564155. IPD Sharing: Not stated. Countries: 0. Publications: 1.
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