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489
datasets available to search
ShareScore release 0.9.0
Dataset results
489 results for “cell plasticity”
Restriction of innate Tgd17 cell plasticity by an AP-1 regulatory axis [multiome]
GEO Series GSE271329. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dynamic plasticity of prostate cancer intermediate cells during androgen receptor targeted therapy
GEO Series GSE205765. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Loss of METTL3 potentiates transposable element expression and drives inflammation-induced cell plasticity in the mammary epithelium [scRNA-seq]
GEO Series GSE280919. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Clonotypic analysis of protective influenza M2e-specific lung resident T helper memory cells reveals extensive functional plasticity
GEO Series GSE161938. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Targeting SWI/SNF ATPases reduces cell invasiveness and plasticity in core transcription factors-addicted neuroblastoma [RNA-seq]
GEO Series GSE240590. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [inDrop]
GEO Series GSE147860. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Jmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity (RNA-Seq)
GEO Series GSE56367. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b
Metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. The pathophysiological course of metastasis is mediated by the dynamic plasticity of cancer cells, which enables them to shift between epithelial and mesenchymal phenotypes through a transcriptionally regulated program termed epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET). Using a mouse model of spontaneous metastatic breast cancer, we investigated the molecular mediators of metastatic competence within a heterogeneous primary tumor and how these cells then manipulated their epithelial-mesenchymal plasticity during the metastatic process. We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b. We found that this ability enabled H19 to modulate the expression of the microRNA targets Git2 and Cyth3, respectively, which encode regulators of the RAS superfamily member adenosine 5′-diphosphate (ADP) ribosylation factor (ARF), a guanosine triphosphatase (GTPase) that promotes cell migration associated with EMT and disseminating tumor cells. Decreasing the abundance of H19 or manipulating that of members in its axis prevented metastasis from grafts in syngeneic mice. Abundance of H19, GIT2, and CYTH3 in patient samples further suggests that H19 might be exploited as a biomarker for metastatic cells within breast tumors and perhaps as a therapeutic target to prevent metastasis.
Kupffer Cell Plasticity
<p>The study by Huang et al. delineates the phenotypic and functional transformation of Kupffer cells (KCs) within metastatic liver microenvironments, characterized by an apparent reprogramming towards an inflammatory macrophage niche prevalent in liver metastasis-associated macrophages (LMAMs). Standard lineage tracing and proliferation recording systems revealed that LMAMs are primarily derived from circulating monocytes, but paradoxically, monocyte ablation only marginally reduced LMAM numbers. Instead, KC infiltration compensated for the monocyte deficit, with KCs displaying significant phenotypic and functional shifts attributable to both increased local macrophage proliferation and epigenetic remodeling. Notably, selective co-culturing with apoptotic cells demonstrated that KC-derived LMAMs retained some original KC functions despite their reprogramming. The study has profound implications for therapeutic interventions, suggesting that targeting both peripheral monocytes and differentiated macrophages in situ may prove more efficacious in reversing immunosuppressive myelopoiesis within liver metastases.</p>
Variations of Immune Infiltrate and Cell Plasticity Markers in Treated Metastatic Melanoma Patients
ClinicalTrials.gov study NCT05029791. IPD Sharing: NO. Countries: 1. Publications: 0.
Plasticity and Regeneration of Renal Epithelial Cells
ClinicalTrials.gov study NCT02820142. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Eng
ClinicalTrials.gov study NCT03173937. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis
ClinicalTrials.gov study NCT03520647. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Functional Plasticity of Human IL-17-producing CD8+ T Cells
ClinicalTrials.gov study NCT03291639. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Functional plasticity and reversible growth behavior of patients’ acute myeloid leukemia stem cells growing in mice
GEO Series GSE141627. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium (RNA-seq III)
GEO Series GSE247252. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single-cell analysis implicates Th17 to Th2 cell plasticity in the pathogenesis of palmoplantar pustulosis [scRNA-Seq]
GEO Series GSE185857. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
EWS-FLI1 and HOXD13 control tumor cell plasticity in Ewing sarcoma [RNA-seq]
GEO Series GSE148494. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
IL6/JAK/STAT3-mediated crosstalk between cancer associated fibroblasts and epithelial cells promotes lineage plasticity and prostate cancer progression [scRNA-seq]
GEO Series GSE236041. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing [RNA-seq]
GEO Series GSE256347. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.