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238
datasets available to search
ShareScore release 0.9.0
Dataset results
238 results for “functional phenotype”
Gut-derived indole propionic acid alleviates liver fibrosis by modulating pro-fibrogenic macrophage phenotype and biological function
GEO Series GSE277148. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function
GEO Series GSE302806. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Morphological profiling of chondrogencially-induced multipotent stromal cell aggregates reveals emergent morphological phenotypes predictive of functional capacity
GEO Series GSE110755. Homo sapiens. 16 samples. Type: Expression profiling by array.
WDFY3 loss-of-function leads to increased proliferation and altered differentiation of neuronal cells underlying the haploinsufficient human phenotype
GEO Series GSE271636. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Antigen-expanded CD8+ gd T cells with NK-like phenotype and function respond in persistent infection [scRNA-seq]
GEO Series GSE216654. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Functional and phenotypic characterizations of common syngeneic tumor cell lines as estrogen receptor positive breast cancer models
GEO Series GSE226910. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants
GEO Series GSE141963. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Microglia-specific loss of PU.1 function rescues neurodegenerative phenotypes in a mouse model of Alzheimer’s disease
GEO Series GSE117868. Mus musculus. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Antigen-expanded CD8+ gd T cells with NK-like phenotype and function respond in persistent infection
GEO Series GSE216658. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Loss of protein function of ZC4H2 gene causing severe phenotypes of female-restricted Wieacker Wolff Syndrome
GEO Series GSE208171. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Phenotypical and functional characterization of human skin dermal dendritic cells and Langerhans cells.
GEO Series GSE72104. Homo sapiens. 20 samples. Type: Expression profiling by array.
Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development.
GEO Series GSE276496. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic and Functional Characterization of Oncohistone Mutations in Breast Cancers
GEO Series GSE295988. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
Hepatic loss-of-function phenotype in the peripheral benzodiazepine receptor (PBR) also known as the mitochondrial translocator protein (TSPO), knockout mice (TSPO-/- mice).
GEO Series GSE228098. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Functional analyses of miR-210 involvement in the aggressive phenotype of high grade breast tumors
GEO Series GSE25162. Homo sapiens. 8 samples. Type: Expression profiling by array.
Data for publication "Transcriptional and functional profiling of Endothelial Colony Forming Cells identifies inflammation and endothelial to mesenchymal transition as drivers for phenotypic heterogeneity"
<p>Here, the data is stored for the article "Transcriptional and functional profiling of Endothelial Colony Forming Cells identifies inflammation and endothelial to mesenchymal transition as drivers for phenotypic heterogeneity" which is currently submitted but not accepted.</p><p>it was not possible to include all data in this repository. the confocal tilescan images used for WPB and Cell morphology quantification and images used for the migration assay were too many and too large in size to include. However, this data is available upon request.</p>
Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
<p>The E3 ubiquitin ligase Ube3a is biallelically expressed in mitotic cells, including neural progenitors and glial cells, raising the possibility that UBE3A gain-of-function mutations might cause neurodevelopmental disorders irrespective of parent-of-origin. To test this possibility, we engineered a mouse line that harbors an autism-linked UBE3A-T485A (T508A in mouse) gain-of-function mutation and evaluated phenotypes in animals that inherited the mutant allele paternally, maternally, or from both parents. We found that both paternally and maternally expressed UBE3A-T485A resulted in elevated UBE3A activity in neural progenitors and glial cells where Ube3a is biallelically expressed. Expression of UBE3A-T485A from the maternal allele, but not the paternal one, led to a persistent elevation of UBE3A activity in postmitotic neurons. Maternal, paternal, or biparental inheritance of the mutant allele promoted embryonic expansion of Zcchc12 lineage interneurons which mature into Sst and Calb2 expressing interneurons, and caused a spectrum of behavioral phenotypes that differed by parent-of-origin. Phenotypes were distinct from those observed in Angelman syndrome model mice that harbor a Ube3a maternal loss-of-function allele. Our study shows that the UBE3A-T485A gain-of-function mutation causes distinct neurodevelopmental phenotypes when inherited maternally or paternally. These findings have clinical implications for a growing number of disease-linked UBE3A gain-of-function mutations.</p> <p>Single-cell RNA-seq (drop-seq) of mouse cerebral cortex from Ube3a-WT, Ube3a-T485A homozygotes, assessed at two ages: E14.5 and P0</p>
Loss of function mutation in progressive ankylosis (Ank) gene causes aberrant mineralization and acquisition of osteoblast-like-phenotype by annulus fibrosus cells in the intervertebral disc
GEO Series GSE206997. Mus musculus. 20 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.