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zenodo40/100

Antiviral activity of HIV-1 integrase strand-transfer inhibitors against mutants with integrase resistance-associated mutations and their frequency in treatment-naïve individuals

<p>The development of  resistance to human immunodeficiency virus 1 (HIV-1) integrase strand-transfer inhibitors (INSTI) has been documented; however, knowledge of the impact of pre-existing integrase (IN) mutations on INSTI resistance (INSTI-R) is still evolving. The frequency of HIV-1 IN mutations in 2177 treatment-na&iuml;ve subjects was investigated, along with the INSTI susceptibility of site-directed mutant viruses containing major and minor INSTI-R mutations. Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in &gt;1% of IN-treatment-na&iuml;ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E157Q led to decreased susceptibility to elvitegravir but remained sensitive to  dolutegravir and bictegravir.</p>

opencc-by-4.0Aug 2019View details →
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Fig. 3. Model B in A new device to autonomously feed individualized mantids on extended periods of time

Fig. 3. Model B autofeeder in operation. (A) Overall view; empty rearing chambers have a cardboard disk blocking the entrance of flies. (B) Four 4th and 5th instar M. aptera Giglio-Tos, 1917 in the rearing cups along with some Drosophila Fallén, 1832 flies. (C) Front view of one end of the equipment, showing the prey cup with culture medium, and Drosophila larvae and flies; note central compartment with prey freely circulating, and the rearing cup with a 4th instar M. aptera hanging in the Tulle fabric. (D) Rearing cup seen through its cover lid, with a 4th instar M. aptera and some prey. (E) Side view of the rearing cup, with a 5th instar M. aptera feeding on a freshly caught Drosophila fly.

opencc-by-4.0Jun 2019View details →
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Figs. 1 and 2. Building schemes for the autofeeders. 1 in A new device to autonomously feed individualized mantids on extended periods of time

Figs. 1 and 2. Building schemes for the autofeeders. 1. Used material, measurements and quantities.2. Assembling. Bottom panel corresponds to an exploded view drawing of the Model A, with mantises' cups on the top. The top right detail is for Model B, with mantises' cups installed laterally, thus holding twice as many cups. CI, first compartment, the rearing chamber, showing a 4th instar, 2.0 cm long Photina sp. (to scale); CII, central or circulation compartment; CIII, third compartment, the prey cup; a, square piece of Tulle fabric with mesh size of 0.3 mm; b, Lid with a square hole (5) in the center; c, translucent mantis cup, with circular hole (4) on the bottom; d, circular piece of Tulle fabric with mesh size of 2.0 mm; e, rectangular PVC pipe with circular holes on the top side (1) and bottom side (2) [serrations on the side is only an effect to show inside the pipe, and is not meant to be carved on pipe!]; f, translucent plastic sheet; g, lid with circular hole (3) on center; h, translucent prey cup; i, culture medium for Drosophila Fallén, 1832. The connections between components a+ b, c+ d+ e, e+ f and e+ g are fixed with PVC adhesive and sealed with thermoplastic adhesive (glue gun). The small orange dots represent drosophila flies, indicating that they must circulate freely between CI, CII and CIII.

opencc-by-4.0Jun 2019View details →
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Figure 4 in Population density and diet type interactively affect individual growth of an omnivorous soil-dwelling insect (Anomala cuprea, Coleoptera: Scarabaeidae)

Figure 4. (a) total carbon (%) in the diet before the experiment and (b) after the experiment, and (c) total nitrogen (%) in the diet before the experiment and (d) after the experiment in the two diets and three population densities.

opencc-by-4.0Nov 2023View details →
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Figure 2 in Population density and diet type interactively affect individual growth of an omnivorous soil-dwelling insect (Anomala cuprea, Coleoptera: Scarabaeidae)

Figure 2. Effects of diet type and population density on mean fresh weight of a larva. Error bars indicate standard error. See Tab. 2 for details of statistical results.

opencc-by-4.0Nov 2023View details →
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Figure 1 in Population density and diet type interactively affect individual growth of an omnivorous soil-dwelling insect (Anomala cuprea, Coleoptera: Scarabaeidae)

Figure 1. Effects of diet type and population density on larval mortality rate. Error bars indicate standard error. See Tab. 1 for details of statistical results.

opencc-by-4.0Nov 2023View details →
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Figure. Shell height and width of Helix pomatia snails collected by rooks, and of individual snails living in the study area. in Rooks (Corvus frugilegus) dine on snails in Poland

Figure. Shell height and width of Helix pomatia snails collected by rooks, and of individual snails living in the study area.

opencc-by-4.0Dec 2013View details →
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Figure. Mean pre-adult development time (in days) values for all strains. Vertical bars denote 0.95 confidence intervals. in Effects of artificial migration of susceptible individuals on resistance and fitness of a fenitrothion-resistant strain of Musca domestica (L.) Diptera

Figure. Mean pre-adult development time (in days) values for all strains. Vertical bars denote 0.95 confidence intervals.

opencc-by-4.0Aug 2013View details →
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Text-fig. 3. Schematic geological section of the Kristina Mine near Hrádek/N. (state in 1963–1964) – height/length ratio 3:1. Explanations: vertical hatching – lignite seam, seamlet; dotted – coarse-grained sand, pea-gravel; short lines – sandy clay; white – clay; black lines – clay ironstone concretions; black dots – individual fossiliferous horizons designated as (A) plastic clay from the upper part of the main xylitic seam (about 5 m under t of the seam, (B) clay and "Blätterkohle" from the uppermost part of the first seamlet (split off the Main Coal Seam), (C) slightly sandy brown clay under the uppermost part of the Main Coal Seam, (D) base of the sandy clay with large concretions of the clay ironstone above the Main Coal Seam, (E) sandy clay (incl. clay ironstone) supplying most of leaf material with cuticles (F) 1–2 cm thin silty lenticles or thin beds of the sandy clay with xylites and Eomastixia within peagravels and coarse-grained sands, (G) coarse-grained sands with clayish silts with Fagus, Ocotea, Pterocarya, Tectocarya, (H) brown sandy clay underlying the uppermost seamlet, (I) lignite clay, base of the uppermost seamlet (J) Glyptostrobus – "Blätterkohle", base of the uppermost seamlet (according to Holý 1975, modified). in A Review Of The Early Miocene Mastixioid Flora Of The Kristina Mine At Hrádek Nad Nisou In North Bohemia (The Czech Republic)

Text-fig. 3. Schematic geological section of the Kristina Mine near Hrádek/N. (state in 1963–1964) – height/length ratio 3:1. Explanations: vertical hatching – lignite seam, seamlet; dotted – coarse-grained sand, pea-gravel; short lines – sandy clay; white – clay; black lines – clay ironstone concretions; black dots – individual fossiliferous horizons designated as (A) plastic clay from the upper part of the main xylitic seam (about 5 m under t of the seam, (B) clay and "Blätterkohle" from the uppermost part of the first seamlet (split off the Main Coal Seam), (C) slightly sandy brown clay under the uppermost part of the Main Coal Seam, (D) base of the sandy clay with large concretions of the clay ironstone above the Main Coal Seam, (E) sandy clay (incl. clay ironstone) supplying most of leaf material with cuticles (F) 1–2 cm thin silty lenticles or thin beds of the sandy clay with xylites and Eomastixia within peagravels and coarse-grained sands, (G) coarse-grained sands with clayish silts with Fagus, Ocotea, Pterocarya, Tectocarya, (H) brown sandy clay underlying the uppermost seamlet, (I) lignite clay, base of the uppermost seamlet (J) Glyptostrobus – "Blätterkohle", base of the uppermost seamlet (according to Holý 1975, modified).

opencc-by-4.0Dec 2012View details →
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Figure 1 in The tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae): pupal key characters for sexing individuals

Figure 1. Pupal stage of the tomato leafminer Tuta absoluta: A) dorsal, B) ventral, and C) lateral views.

opencc-by-4.0Apr 2016View details →
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Figure 2 in The tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae): pupal key characters for sexing individuals

Figure 2. Ventral views of female and male pupae of the tomato leafminer. Abdominal segments indicated as 5th (A5), 6th (A6), 7th (A7), 8th (A8), 9th (A9), and 10th (A10).

opencc-by-4.0Apr 2016View details →
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Figure 4 in Estimation of individual growth of the violet oyster Chama coralloides Reeve, 1846 (Bivalvia: Venerida) using Schnute model cases

Figure 4. Fitted growth curves for the best cases of the Schnute model for a population of C. coralloides in Acapulco, Guerrero, Mexico (* indicates the best model).

opencc-by-4.0Sep 2023View details →
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Figure 2 in Estimation of individual growth of the violet oyster Chama coralloides Reeve, 1846 (Bivalvia: Venerida) using Schnute model cases

Figure 2. Monthly frequency distribution of lengths (bars) and modal groups (curves) for C. coralloides in Acapulco, Guerrero, Mexico.

opencc-by-4.0Sep 2023View details →
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Figure 7. One individual P in New ecological information on the little-known Sumatran endemics Black-and-white langur Presbytis bicolor Aimi & Bakar, 1992 (Primates: Cercopithecidae)

Figure 7. One individual P. bicolor watching in great care to the people who get closer, 5 June 2015, Talang Lakat, Bukit Tiga Puluh National Park, Jambi Province (Photo: Rhett Butler).

opencc-by-4.0Feb 2023View details →
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Fig. 3 in Ecological, parasitological and individual determinants of plasma neopterin levels in a natural mandrill population

Fig. 3. Plasma neopterin concentrations (raw values) in relation to P. Gonderi parasitaemia in adult males.

opencc-by-4.0Apr 2020View details →
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Fig. 1 in Ecological, parasitological and individual determinants of plasma neopterin levels in a natural mandrill population

Fig. 1. Plasma neopterin concentrations (raw values) in relation to individual sex. The bottom and top of the box respectively represent the 25th and 75th quartiles, and the bold horizontal line the median. Whiskers show the interquartile range. Open squares indicate the mean of the distribution. Comparisons are denoted by "*" if significant.

opencc-by-4.0Apr 2020View details →
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Fig. 5. Individual B in Description of head scalation variation, hemipenis, reproduction, and behavior of the Indian Smooth Snake, Coronella brachyura (Günther 1866)

Fig. 5. Individual B, both sides eight supralabials, fourth and fifth in contact with eye, and second and third supralabials in contact with loreal scale. (A) Left side. (B) Right side. (C) Live individual with same scalation. Photo credit Dikansh S. Parmar.

opencc-by-4.0Feb 2019View details →
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Fig. 4. Individual C in Description of head scalation variation, hemipenis, reproduction, and behavior of the Indian Smooth Snake, Coronella brachyura (Günther 1866)

Fig. 4. Individual C, both sides nine supralabials, fifth and sixth supralabials in contact with eye, and second, third, and fourth supralabials in contact with loreal scale. (A) Left side. (B) Right side. Photo credit Dikansh S. Parmar.

opencc-by-4.0Feb 2019View details →
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Fig. 3. Individual A in Description of head scalation variation, hemipenis, reproduction, and behavior of the Indian Smooth Snake, Coronella brachyura (Günther 1866)

Fig. 3. Individual A, both sides nine supralabials, fifth and sixth supralabials in contact with eye, and second, third, and fourth supralabials in contact with loreal scale. (A) Left side. (B) Right side. Photo credit Dikansh S. Parmar.

opencc-by-4.0Feb 2019View details →
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BVOC Fluxes from Individual Branches in the Mixed Mediterranean Shrubbery of Ramat Hanadiv

<p>Fluxes were derived from BVOCs sampled from individual branches in the mixed Mediterranean shrubbery of Ramat Hanadiv Nature Park. We conducted branch-enclosure sampling measurements on six selected branches of <em>Phillyrea latifolia</em>&mdash;the highest BVOC emitter in this park&mdash;during September&ndash;October 2020. These samples were then analyzed by gas chromatography-mass spectrometry to identify BVOCs and quantify their fluxes. The data was used for a publication&nbsp; -https://doi.org/10.5194/egusphere-2024-529, 2024</p>

opencc-by-4.0Aug 2024View details →

ScienceDex guides

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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.

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Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas
neuroscienceopenDocumentation, web resources, and API references are available online.
Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage
behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.
Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb
electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.
Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl
behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.
Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro
neuroscienceopenPublished datasets are available on demand over the internet.
Last verified 2026-04-29Open record

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Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.