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ShareScore release 0.9.0
Dataset results
243 results for “mitochondrial dysfunction”
NMR based clinical metabolomics study revealed aberrant proline biosynthesis and mitochondrial dysfunction in patients of mild cognitive impairment
<p>The prevalence of type-2 diabetes mellitus (T2DM) is tremendously increasing in older population because of several reasons and studies have shown that such old-age T2DM patients have 50-65% higher risk of developing cognitive impairment and its progression towards mild cognitive impairment (MCI). The studies claim that in the majority of MCI patients, the diabetes selectively involves the brain and the condition is now considered as a neuroendocrine disorder, even referred to as type 3 diabetes (T3D). Impaired glucose metabolism and mitochondrial dysfunction in neurodegenerative diseases, particularly in MCI, is compelling. Therefore, clinical interest is emerging to understand the role of mitochondria in T2DM and T3D which may provide important insights into pathogenesis of such chronic diseases and may indeed provide a target for improved patient care. The present study, therefore, aims to compare the serum metabolic profiles of MCI patients with age and sex matched T2DM patients with respect to normal control (NC) subjects. The results revealed that abnormal glutamate-to-glutamine cycling and proline metabolism in MCI patients. Compared to T2DM patients, the elevated circulatory proline levels in MCI patients hinted towards abnormal mitochondrial functioning underlying cognitive impairment.</p>
Use of Muscle Spectroscopy to Evaluate Mitochondrial Dysfunction in HIV-Infected Patients
ClinicalTrials.gov study NCT00036478. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MYC plus class IIa HDAC inhibiton potentiates mitochondrial dysfunction in non-small cell lung cancer [I]
GEO Series GSE281767. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Enhanced Myocardial Glucose Delivery Accelerates Development of Mitochondrial Dysfunction in the Diabetic Heart
GEO Series GSE123975. Mus musculus. 24 samples. Type: Expression profiling by array.
Glycogen stress granules cause astrocytic mitochondrial dysfunction to aggravate ischemic damage and delay recovery after stroke
GEO Series GSE295882. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Mutant p53 binds RNA to drive mitochondrial dysfunction [RNA-seq]
GEO Series GSE310614. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
GEO Series GSE154050. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial translation drives activated CD8+ T cell dysfunction
GEO Series GSE282220. Mus musculus. 4 samples. Type: Other.
A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F1_Liv_eWAT_RNAseq]
GEO Series GSE282189. Mus musculus. 31 samples. Type: Expression profiling by high throughput sequencing.
SFXN2 contributes mitochondrial dysfunction‑induced apoptosis as a substrate of Parkin
GEO Series GSE294872. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Differential Gene Expression and Mitochondrial Dysfunction in Imprinting center deletion (PWS- IC del) Mouse model of Prader-Willi Syndrome
GEO Series GSE41759. Mus musculus. 14 samples. Type: Expression profiling by array.
MYC plus class IIa HDAC inhibiton potentiates mitochondrial dysfunction in non-small cell lung cancer [ATAC-seq]
GEO Series GSE279134. Homo sapiens. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Pharmacologic targeting of SUMOylation drives mitochondrial dysfunction and metabolic alterations in B cell Malignancies
GEO Series GSE254913. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis
GEO Series GSE261940. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Cross-Species Single-Cell Analysis Reveals Sex Differences in Mitochondrial Dysfunction as a Conserved Feature of Tau Pathology
GEO Series GSE310345. Danio rerio. 8 samples. Type: Expression profiling by high throughput sequencing.
HO-1 modulates ferroptosis via ROS-mediated mitochondrial dysfunction in cyclophosphamide -induced ovarian granulosa cells
GEO Series GSE243720. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast
GEO Series GSE252348. Saccharomyces cerevisiae. 21 samples. Type: Expression profiling by high throughput sequencing.
Oral Vutiglabridin mitigates retinal degeneration by targeting mitochondrial dysfunction and retinal pigment epithelium senescence in mouse models
GEO Series GSE307930. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of cytosolic translation mitigates mitochondrial dysfunction in C. elegans
GEO Series GSE290561. Caenorhabditis elegans. 11 samples. Type: Expression profiling by high throughput sequencing.
A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline
GEO Series GSE280278. Mus musculus. 279 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.