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779 results for “pigment”
Fig. 5 in Characterization of the PRODUCTION of ANTHOCYANIN PIGMENT 1 Arabidopsis dominant mutant using DLEMMA dual isotope labeling approach
Fig. 5. Linear correlation between labeling efficiency and metabolite location in the phenylpropanoid pathway. The number next to each point corresponds to metabolite location shown in Table 1. 'L' stands for location, the number after 'L' indicates its location in the phenylpropanoid pathway. The number in the bracket is used to distinguish metabolites that are at the same pathway location; LE: labeling efficiency. The color scale represents different percentage of labeling efficiency.
Fig. 2. A in Characterization of the PRODUCTION of ANTHOCYANIN PIGMENT 1 Arabidopsis dominant mutant using DLEMMA dual isotope labeling approach
Fig. 2. A representative example of metabolite identification using DLEMMA. (A) An isotopologue cluster was identified. All information necessary for metabolite identification such as retention time (RT), m/z values and number of labeled atoms, was depicted in a table (B) The raw MS data was first inspected (i.e. RT and m/z values) to validate the results obtained by the Miso software. (C) Elemental composition was then determined using the Masslynx software based on accurate unlabeled m/z and natural isotope patterns. Next, elemental compositions C15H16O9 was searched in SciFinder, and 108 possible candidates were found. The structural information obtained from the labeling patterns was then used to narrow down the number of candidates. Combined with MS/MS information, this metabolite was identified as sinapoyl malate.
Fig. 1 in Characterization of the PRODUCTION of ANTHOCYANIN PIGMENT 1 Arabidopsis dominant mutant using DLEMMA dual isotope labeling approach
Fig. 1. Overview of the DLEMMA workflow employed in this study. (A) Three differently labeled forms of phenylalanine (Phe) were used as feeding precursors, i.e. unlabeled, Label I (Phe-13C), and Label II (Phe-13C2H) Phe. (B) The two Arabidopsis genotype groups, WT and pap1-D, were fed with three forms of labeling 6 6 5 precursors for 24h. (C) Following feeding, the six treatments were combined (i.e. combinations A to F), in which four combinations were designed for metabolite identification and another two for semi-quantitative differential metabolite analysis. The extracts were analyzed by high resolution LC-MS in both positive and negative ion modes. (D) The LC-MS raw data was preprocessed with the R package XCMS, and next the R package Miso was used to detect and extract all Phe-derived mass features. (E) Phe-derived metabolites were identified based on retention time, m/z, MS/MS spectra, and dual-labeling patterns obtained from LC-MS analysis. (F) A combined sample matrices and label-swap approach was used to semi-quantitatively compare phenylpropanoids content between the WT and pap1- D genotypes.
Fig. 3. A in Characterization of the PRODUCTION of ANTHOCYANIN PIGMENT 1 Arabidopsis dominant mutant using DLEMMA dual isotope labeling approach
Fig. 3. A representative example demonstrating metabolite structure elucidation by DLEMMA in cases where multiple different labeling patterns are detected. An isotopologue cluster was detected with multiple different labeling patterns being observed, i.e. m/z+6, m/z+9, m/z+10, m/z+12, m/z+15, m/z+16 and m/z+19. Two possible elemental compositions were found for this metabolite. SciFinder database search revealed that only one structure matched all the 7 observed labeling patterns and this metabolite identified as Cyanidin 3-O-[2-O-(xylosyl)-6-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside.
Fig. 4 in Characterization of the PRODUCTION of ANTHOCYANIN PIGMENT 1 Arabidopsis dominant mutant using DLEMMA dual isotope labeling approach
Fig. 4. Comparison of ion intensities of ferulic acid-hexose detected from phenylalanine fed and non-fed Arabidopsis leaves. (A) Extracted ion chromatogram (1) and mass spectrum (2) of ferulic acid-hexose from non-fed WT Arabidopsis. (B) Extracted ion chromatogram (1) and mass spectrum (2) of ferulic acid-hexose from unlabeled Phe fed WT Arabidopsis. Two isomers of ferulic acid-hexose, eluting at 6.10 and 6.66 min, were detected. The representative mass spectra are from ferulic acid-hexose isomer I (RT = 6.10 min). Peak areas of two ferulic acid-hexose isomers were used to compare their contents between non-fed and un-labeled Phe fed leaves.
Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population
<p>Interest in the genetic basis of variation in skin pigmentation in Native American populations led us to seek indigenous populations of the Western Hemisphere with African and minimal European admixture to study the effect of Native American ancestry on skin color. Admixture analysis from DNA collected from 458 individuals in the Kalinago territory of the Commonwealth of Dominica showed shared ancestry with East Asians at K=3 and 55% Native American, 32% African, and 11% European ancestry at K=6, the highest Native American ancestry of Caribbean populations. Skin pigmentation was 20 to 80 melanin units, averaging 46. Three albino individuals were homozygous for multi-nucleotide polymorphism OCA2<sup>NW273KV</sup> of African origin, whose population allele frequency was 0.03 and single allele effect size was -8 melanin units. Hypopigmenting allele frequencies for SLC24A5<sup>A111T</sup> and SLC45A2<sup>L374F</sup> were 0.14 and 0.05, whose single allele effect sizes were -6 and -3, respectively. Skin color plots of individuals lacking known hypopigmenting alleles suggests that Native American Ancestry reduced pigmentation by more than 20 melanin units (low and high estimates 21.8 and 28.5). Shared ancestry with East Asians at K=3 suggests potential sharing of one or more pigmentation alleles.</p>
Bermuda Atlantic Time-Series Study (BATS) Pigment Data Validation
<p>This dataset is published on Zenodo by the Simons CMAP curators for long-term care. All credits go to the data producers at the Bermuda Atlantic Time-series Study (BATS): https://bats.bios.asu.edu/bats-data/ </p><p>The BATS (Bermuda Atlantic Time-series Study) discrete HPLC pigment validation dataset is time-series spanning from 1996 to 2022. The dataset contains the 21 separate in-situ pigment measurements along with sampling depth and the BATS Cruise ID.</p><p>This description has been reproduced using https://www.dropbox.com/s/6ajl545hyua8ot8/bval_pigments.txt?dl=0</p>
Evaluation of Laser Treatment for Benign Pigmented Lesions by Non-invasive, Cellular Resolution Optical Coherence Tomography
ClinicalTrials.gov study NCT04861246. IPD Sharing: NO. Countries: 1. Publications: 10.
Lucentis for Age-related Macular Degeneration Pigment Epithelial Detachments
ClinicalTrials.gov study NCT00590694. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ranibizumab for Treating Submacular Vascularized Pigment Epithelial Detachments
ClinicalTrials.gov study NCT00749021. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)
ClinicalTrials.gov study NCT01261429. IPD Sharing: Not stated. Countries: 5. Publications: 9.
Effects of Antioxidants on Human Macular Pigments
ClinicalTrials.gov study NCT00718653. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of the Pigment-free Optical Zone Diameter of Decorative Tinted Soft Contact Lenses on Visual Function
ClinicalTrials.gov study NCT02537275. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC)
ClinicalTrials.gov study NCT00668291. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD)
ClinicalTrials.gov study NCT02142296. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tracing the Path of an Ingested Plant Pigment Through the Human Body
ClinicalTrials.gov study NCT01106729. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
ClinicalTrials.gov study NCT00001452. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Comparison of Picosecond and Q-switched Laser for Benign Pigmented Lesions Treatment
ClinicalTrials.gov study NCT02800525. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Vitamin E Prevention of Visible Light Pigmentation
ClinicalTrials.gov study NCT01927679. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Augmented Macular Pigment-containing Nutraceutical and Central Visual Function
ClinicalTrials.gov study NCT04676126. IPD Sharing: NO. Countries: 1. Publications: 30.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.