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951 results for “places”
Data from: Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life
<p><span>Many proteins exist in the so-called "twilight zone" of sequence alignment, where low pairwise sequence identity makes it difficult to determine homology and phylogeny. As protein tertiary structure is often more conserved, recent advances in<em> ab initio </em>protein folding have made structure-based identification of putative homologs feasible. However, structural screening and phylogenetics are in their infancy, particularly for twilight zone proteins. We present a pipeline for the identification and characterization of distant homologs, and apply it to 7-transmembrane domain ion channels (7TMICs), a protein group founded by insect Odorant and Gustatory receptors. Previous sequence and limited structure-based searches identified putatively-related proteins, mainly in other animals and plants. However, very few 7TMICs have been identified in non-animal, non-plant taxa. Moreover, these proteins' remarkable sequence dissimilarity made it uncertain if disparate 7TMIC types (Gr/Or, Grl, GRL, DUF3537, PHTF and GrlHz) are homologous or convergent, leaving their evolutionary history unresolved. Our pipeline identified thousands of new 7TMICs in archaea, bacteria and unicellular eukaryotes. Using graph-based analyses and protein language models to extract family-wide signatures, we demonstrate that 7TMICs have structure and sequence similarity, supporting homology. Through sequence and structure-based phylogenetics, we classify eukaryotic 7TMICs into two families (Class-A and Class-B), which are the result of a gene duplication predating the split(s) leading to Amorphea (animals, fungi and allies) and Diaphoretickes (plants and allies). Our work reveals 7TMICs as a cryptic superfamily with origins close to the evolution of cellular life. More generally, this study serves as a methodological proof of principle for the identification of extremely distant protein homologs.</span></p>
Fig. 1 in Taxonomic Revision and Classification of Extant Holococcolithophores Previously Placed in the Genus Anthosphaera Kamptner emend. Kleijne 1991
Fig. 1. Map of the sampling locations, where Anthosphaera was observed.
John Snow Society's 210th Anniversary Map Competition Second Place award
<p>John Snow's iconic 1854 map of the clustering of cholera deaths in Soho London was one of the best and earliest uses of epidemiology and geospatial analysis to investigate an outbreak, and led to the identification of the probable infection source – a water pump in Broad Street. https://johnsnowsociety.org/broadsheets-lectures-social/#SocialMedia</p><p>The spike map shows the density of cholera deaths in the Soho area. This visualisation offers a novel birds-eye-view perspective of the deaths distribution surrounding the Broad Street pump.</p><p>#johnsnow #choleramap #gis #mapping #disease</p>
Activate For Life: mHealth Intervention To Address Pain And Fatigue In Low-income Older Adults Aging In Place
ClinicalTrials.gov study NCT03853148. IPD Sharing: NO. Countries: 1. Publications: 2.
Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy
ClinicalTrials.gov study NCT00927849. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Place of Imaging and Microbiology in the Diagnosis of Pneumonia in the Elderly
ClinicalTrials.gov study NCT02467192. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Comparison of the Levonorgestrel IUD and the Copper IUD Placed in the Immediate Postplacental Period: A Prospective Cohort Study
ClinicalTrials.gov study NCT02067663. IPD Sharing: NO. Countries: 1. Publications: 32.
The Need of Fiberoptic Bronchoscopy for Placing an Endobronchial Blocker
ClinicalTrials.gov study NCT02133235. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study Comparing Two Methods of Placing an Interscalene Nerve Catheter for Postoperative Pain Control in Patients Who Undergo Open Shoulder Surgery.
ClinicalTrials.gov study NCT01696188. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study Comparing Appearance and Function of Three Different Dental Implant Designs When Placed in Front Region of Upper Jaw
ClinicalTrials.gov study NCT00820235. IPD Sharing: Not stated. Countries: 2. Publications: 3.
PLACE Trial: Preserving Long-Acting Contraception Through Education
ClinicalTrials.gov study NCT07271836. IPD Sharing: YES. Countries: 1. Publications: 1.
Clinical Outcomes of Deep Brain Stimulator (DBS) Electrodes Placed Using Intraoperative Computed Tomography (CT) and Frameless Stereotaxis
ClinicalTrials.gov study NCT01703598. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dataset for the transcriptome analysis of hippocampal subfields identifies gene expression profiles associated with long-term active place avoidance memory
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Data from: Central place foraging and the long-term liability of selecting the ‘wrong’ central place
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Data from: A place-based participatory mapping approach for assessing cultural ecosystem services in urban green space
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Data for: MOGrip: Gripper for multi-object grasping in pick-and-place tasks using translational movements of fingers
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Data from: Siring success in kangaroos: size matters for those in the right place at the right time
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Unravelling the mystery of red flowers in the Mediterranean Basin: How to be conspicuous in a place dominated by hymenopteran pollinators
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Data from: Prey encounters and spatial memory influence use of foraging patches in a marine central place forager
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Analysis of biodiversity data suggests that mammal species are hidden in predictable places
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ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.