Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
256
datasets available to search
ShareScore release 0.9.0
Dataset results
256 results for “sporadic”
Characterization of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumors
GEO Series GSE32578. Homo sapiens. 94 samples. Type: Genome variation profiling by genome tiling array.
SETD1A Regulates Psychiatric Gene Networks Involved in Genomic Stability and Synaptic Function in Rare and Sporadic Schizophrenia [CUT&Tag]
GEO Series GSE293154. Homo sapiens. 48 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Whole transcriptome analysis of unmutated sporadic ALS patients’ peripheral blood reveals phenotype-specific gene expression signature
GEO Series GSE288704. Homo sapiens. 66 samples. Type: Expression profiling by high throughput sequencing.
Sporadic activation of an oxidative stress-dependent NRF2–p53 signaling network in breast epithelial spheroids and premalignancies
GEO Series GSE141228. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Persistent epigenome anomalies in induced pluripotent stem cells from late-onset sporadic Alzheimer’s disease cases [RNA-seq]
GEO Series GSE255982. Homo sapiens. 52 samples. Type: Expression profiling by high throughput sequencing.
Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers
GEO Series GSE61438. Homo sapiens. 69 samples. Type: Non-coding RNA profiling by array.
Copy number analysis of familial and sporadic Epithelial Ovarian Carcinomas (EOC) from FFPE tissue on high resolution Agilent platform.
GEO Series GSE41253. Homo sapiens. 68 samples. Type: Genome variation profiling by genome tiling array.
Stem cell derived spinal cord chips reproduce disease biomarkers in sporadic ALS patients [bulk RNAseq]
GEO Series GSE255602. Homo sapiens. 71 samples. Type: Expression profiling by high throughput sequencing.
The dual role of mast cells in sporadic colorectal tumorigenesis: clinical and experimental evidence
GEO Series GSE128712. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier
GEO Series GSE255606. Homo sapiens. 88 samples. Type: Expression profiling by high throughput sequencing.
Stem cell derived spinal cord chips reproduce disease biomarkers in sporadic ALS patients [snRNAseq]
GEO Series GSE255605. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Brain regional and cell type-specific chromatin changes among sporadic, GBA1 variant, and APOE E4 Parkinson’s Disease
GEO Series GSE273511. Homo sapiens. 426 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Early age of onset is an independent predictor for worse disease-free survival in sporadic rectal cancer patients. A comparative analysis of 980 consecutive patients "
<p>This record contains raw data related to article “Early age of onset is an independent predictor for worse disease-free survival in sporadic rectal cancer patients. A comparative analysis of 980 consecutive patients"</p> <p><strong>Background: </strong> while interest on early-onset colorectal cancer (age ≤49) is on the rise, studies on early-onset rectal cancer (EORC) are limited. The aim of this study was to compare predictors for disease progression/recurrence between sporadic EORC and late-onset RC patients (LORC).</p> <p><strong>Methods: </strong> 163 EORC and 830 LORC operated between January 1st<sup>,</sup> 2010 and April 30th<sup>,</sup> 2021 at a tertiary center were included. Demographics, tumor characteristics, microsatellite status, gene mutations (KRAS, BRAF, NRAS, PI3Kca) and oncologic outcomes were compared. A Cox proportional hazards regression analysis was performed to ascertain the effect of variables on recurrence/progression and death. Recurrence/Progression free survival (R/PFS) and cancer specific survival (CSS) were analyzed by the Kaplan-Meier estimator.</p> <p><strong>Results: </strong> Mean age of EORC was 42.16, (46% aged 45-49). A majority of EORC patients had a family history for CRC (p = 0.01) and underwent total neoadjuvant treatment (p = 0.01). EORC patients showed a higher rate of low-grade tumor differentiation (p < 0.0001), stage III-IV (p = 0.001), microsatellite instability (p = 0.02), locoregional nodal (p = 0.001) and distant metastases (p < 0.0001). Accordingly, more EORC patients underwent adjuvant treatment (p < 0.0001). Mutations were mostly reported among LORC cases (p = 0.04), whereas EORC patients showed a worse R/PFS (p = 0.02), even at stage I (p = 0.04). CSS did not differ (p = 0.11) across groups. Multivariate analysis indicated age of onset (p = 0.04) was an independent predictor for progression/recurrence.</p> <p><strong>Conclusions: </strong> Age of onset was shown to be an independent unfavorable predictor. Delayed diagnosis could explain this effect in the more advanced stages, while the worse outcomes in stage I may suggest a more aggressive disease behavior.</p> <p> </p>
Dataset related to article: "Different Oncologic Outcomes in Early-Onset and Late-Onset Sporadic Colorectal Cancer: A Regression Analysis on 2073 Patients"
<p>This record contains data related to article: "Different Oncologic Outcomes in Early-Onset and Late-Onset Sporadic Colorectal Cancer: A Regression Analysis on 2073 Patients"</p> <p>The incidence of colorectal cancer (CRC) is increasing in the population aged ≤ 49 (early-onset CRC-EOCRC). Recent studies highlighted the biological and clinical differences between EOCRC and late-onset CRC (LOCRC-age ≥ 50), while comparative results about long-term survival are still debated. This study aimed to investigate whether age of onset may impact on oncologic outcomes in a surgical population of sporadic CRC patients. Patients operated on for sporadic CRC from January 2010 to January 2022 were allocated to the EOCRC and LOCRC groups. The primary endpoint was the recurrence/progression-free survival (R/PFS). A total of 423 EOCRC and 1650 LOCRC was included. EOCRC had a worse R/PFS (<em>p</em> &lt; 0.0001) and cancer specific survival (<em>p</em> &lt; 0.0001) compared with LOCRC. At Cox regression analysis, age of onset, tumoral stage, signet ring cells, extramural/lymphovascular/perineural veins invasion, and neoadjuvant therapy were independent risk factors for R/P. The analysis by tumoral stage showed an increased incidence of recurrence in stage I EOCRC (<em>p</em> = 0.014), and early age of onset was an independent predictor for recurrence (<em>p</em> = 0.035). Early age of onset was an independent predictor for worse prognosis, this effect was stronger in stage I patients suggesting a potentially-and still unknown-more aggressive tumoral phenotype in EOCRC.</p>
Persistent epigenome anomalies in induced pluripotent stem cells from late-onset sporadic Alzheimer’s disease cases [BiSulfite-seq]
GEO Series GSE255983. Homo sapiens. 4 samples. Type: Methylation profiling by high throughput sequencing.
RNA-Binding Activity of PHGDH Drives Amyloid-beta Production in A Human Brain Organoid Model of Sporadic Alzheimer’s Disease
GEO Series GSE302314. Homo sapiens. 8 samples. Type: Other.
Deregulation of the Hippo pathway promotestumor cell proliferation through YAP activity in human sporadic vestibular schwannoma
GEO Series GSE108237. Homo sapiens. 14 samples. Type: Expression profiling by array.
Protective effects of two different chaperones demonstrated in a mouse model of sporadic AD
GEO Series GSE288054. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
DPYS as a potential diagnostic biomarker in hereditary and sporadic PRCC2
GEO Series GSE48352. Homo sapiens. 32 samples. Type: Expression profiling by array.
Persistent epigenome anomalies in induced pluripotent stem cells from late-onset sporadic Alzheimer’s disease cases [scRNA-seq]
GEO Series GSE255981. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.