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1,041 results for “targeted therapy”
An AAV Gene Therapy Computes Over Multiple Cellular Inputs to Enable Precise Targeting of Multifocal Hepatocellular Carcinoma in Mice
<p>Data underlying the figures in the publication “An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice”, published in <em>Sci. Transl. Med.</em>, <strong>2021</strong>, 13, eabh4456.</p> <p><a href="https://doi.org/10.1126/scitranslmed.abh4456">DOI: 10.1126/scitranslmed.abh4456</a></p> <p>Table of contents:</p> <p><strong>1. Supplementary Material</strong>: File containing Materials and Methods, <em>Fig S1-S8</em>, <em>Table S1</em>, Legend for <em>Table S2</em>, Legends for data files <em>S1</em> and <em>S2</em> and References (63-65).</p> <p><strong>2. Dataset 1.xlsx</strong>: Raw data points used to create the main figures of the paper (<em>1C, 1D, 2B, 2C, 2E, 2G, 2H, 2I, 2K, 3A, 3B, 3C, 4B, 4C, 51, 6A, 7A, 7B, 8B, 8C </em>and<em> 8F</em>) arranged in worksheets panel by panel. The processing steps are described in the methods section of the manuscript and in the supplementary material.</p> <p><strong>3. Dataset 2.xlsx:</strong> Raw data points used to create the supplementary figures of the paper (<em>S1A, S1B, S1C, S3D, S3E, S4A, S4B, S5B, S8A, S8B </em>and <em>S8C</em>) arranged in worksheets panel by panel. The processing steps are described in the methods section of the manuscript and in the supplementary material.</p> <p><strong>4. Table S2</strong>: Experimental data for <em>Table S2.</em></p>
Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, accepted for publication in Scientifc Reports, entitled:</strong></p> <p><strong>Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.</strong></p> <p><strong>Authored by:</strong></p> <p>Elin Sandberg <sup>1</sup>, Chinmaya V Srambickal <sup>1</sup>, Joachim Piguet <sup>1</sup>, Haichun Liu <sup>1</sup> and Jerker Widengren <sup>1,</sup>*</p> <p><sup>1</sup> Experimental Biomolecular Physics, Department of Applied Physics, Royal Institute of Technology (KTH), Stockholm, Sweden</p> <p><sup>* </sup>To whom correspondence should be addressed. Email: jwideng@kth.se. Tel: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped with respect to the figures/tables in the manuscript where the extracted results are presented. </strong></p> <p><strong>ABSTRACT</strong></p> <p>Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states. Monitoring these states <em>in situ</em> can provide important feedback but is difficult in practice. The states are strongly influenced by local oxygenation, pH and redox conditions, often varying significantly at PDT treatment sites. To overcome this problem, we followed local PDT precursor state populations of PS compounds, via their fluorescence intensity response to systematically varied excitation light modulation. Thereby, we could demonstrate local monitoring of PDT precursor states of methylene blue (MB) and IRdye700DX (IR700), and determined their transitions rates under different oxygenation, pH and redox conditions. By fiber-optics, using one fiber for both excitation and fluorescence detection, the triplet and photo-radical state kinetics of locally applied MB and IR700 could then be monitored in a tissue sample. Finally, potassium iodide and ascorbate were added as possible PDT adjuvants, enhancing intersystem crossing and photoreduction, respectively, and their effects on the PDT precursor states of MB and IR700 could be locally monitored. Taken together, the presented procedure overcomes current methodological limitations and can offer feedback, guiding both excitation and PDT adjuvant application, and thereby more efficient and targeted PDT treatments.</p>
UAB 0718 - Phase II Trial to Assess Target Oral Therapy as Adjuvant Chemoprevention in High-Risk Head and Neck Cancer
ClinicalTrials.gov study NCT00570232. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations
ClinicalTrials.gov study NCT02949843. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Abbreviated MAPK Targeted Therapy Plus Pembrolizumab in Melanoma
ClinicalTrials.gov study NCT03149029. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer
ClinicalTrials.gov study NCT06623396. IPD Sharing: YES. Countries: 1. Publications: 0.
Evaluating Anatomic Versus Targeted Lead Placement for Burst Stimulation Therapy During the Trial
ClinicalTrials.gov study NCT03277378. IPD Sharing: NO. Countries: 7. Publications: 0.
Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
ClinicalTrials.gov study NCT02795156. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Iterative Design Trial to Assess Dietary Supplements and Other Aging-targeted Therapies
ClinicalTrials.gov study NCT07202403. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Targeted Therapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia
ClinicalTrials.gov study NCT01620216. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Early and Active Nutritional and Dietary Management grade3 or More Toxicities Induced by Chemotherapy and Targeted Therapies Administered to Patients as First Intention for Non Surgical Meta
ClinicalTrials.gov study NCT01143285. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PET/CT-Guided Biological Target Volume Delineation and Dose Optimization for Radioactive Seed Implantation Therapy in Malignant Tumors
ClinicalTrials.gov study NCT07327515. IPD Sharing: YES. Countries: 1. Publications: 0.
The Role of Highly Selective Androgen Receptor (AR) Targeted Therapy in Men With Biochemically Relapsed Hormone Sensitive Prostate Cancer
ClinicalTrials.gov study NCT01790126. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Assess the Effect of Y-90 Therapy on Non-target/Background Liver
ClinicalTrials.gov study NCT02966223. IPD Sharing: NO. Countries: 1. Publications: 0.
F-18 FES PET/CT in Measuring Hormone Expression in Patients With Primary, Recurrent, or Metastatic Breast Cancer Undergoing Endocrine-Targeted Therapy
ClinicalTrials.gov study NCT02149173. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT04512716. IPD Sharing: YES. Countries: 1. Publications: 0.
Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic
ClinicalTrials.gov study NCT02094872. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Umbrella Trial of Subtype-Targeted Therapies in ER+/HER2- Breast Cancer
ClinicalTrials.gov study NCT05101564. IPD Sharing: NO. Countries: 1. Publications: 0.
BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With
ClinicalTrials.gov study NCT04214249. IPD Sharing: YES. Countries: 1. Publications: 0.
Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC
ClinicalTrials.gov study NCT06804850. IPD Sharing: NO. Countries: 0. Publications: 9.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.