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Dataset results
34,558 results for “therapy”
Microbiome-based biomarkers to guide personalized microbiome-based therapies for Parkinson's disease
<p><strong>Abstract: </strong>We address an unmet challenge in Parkinson’s disease: the lack of biomarkers to identify the right patients for the right therapy, which is a main reason clinical trials for disease modifying treatments have all failed. The gut microbiome is a new target for treatment of neurodegenerative diseases. Our aim was to develop microbiome-based biomarkers to guide patient selection for microbiome-based clinical trials. We used microbial taxa that are robustly associated with PD across studies and at high significance as dysbiotic features of PD. Using individual-level taxonomic relative abundance data, we classified patients according to their dysbiotic features, effectively defining microbiome-based subtypes of PD. We show that not all persons with PD have a dysbiotic microbiome, and not all dysbiotic PD microbiomes have the same features. Grounded in robust and reproducible data from differential abundance studies, we propose an intuitive and easily modifiable method to identify the optimal candidates for microbiome-based clinical trials, and subsequently, for treatments that are personalized for each individual’s dysbiotic features. We demonstrate the method for PD. The concept, and the method, is generalizable for any disease with a microbiome component.</p> <p><strong>Zenodo</strong> <strong>content: </strong>In this Zenodo archive we provide (a) the method described step by step, which can be implemented in Microsoft Excel (we used v.16.84 (RRID:SCR_016137) <a href="https://www.microsoft.com/en-gb/">https://www.microsoft.com/en-gb/</a>) or in R (we used v4.3.3 (RRID:SCR_001905) <a title="https://www.r-project.org/ Cmd+Click or tap to follow the link" href="https://www.r-project.org/">https://www.r-project.org/</a>); and (b) data used to generate the results, tables and figures (except figure 2). Data for creating figure 2 can be found in source data (doi: 10.5281/zenodo.7246185) and the method is described by Wallen et al 2022 (DOI: <u><a href="https://doi.org/10.1038/s41467-022-34667-x" target="_blank" rel="noopener">10.1038/s41467-022-34667-x</a></u>). All data used here were extracted from the original source data reported by<strong> </strong>Wallen et. al. 2022 (DOI: <u><a href="https://doi.org/10.1038/s41467-022-34667-x" target="_blank" rel="noopener">10.1038/s41467-022-34667-x</a></u>) which can be found on Zenodo (DOI: 10.5281/zenodo.7246185).</p>
Isoniazid Preventive Therapy (IPT) uptake and Tuberculin Skin Test (TST) uptake among adults receiving primary HIV care in South Africa .
<p>We aimed to evaluate Isoniazid Preventive Therapy (IPT) and tuberculin skin testing (TST) uptake under primary care clinic conditions, and determine health care worker (HCW) fidelity to the 2014 South African IPT guidelines. Following training on IPT guidelines and tuberculin skin testing (TST), 3 primary care clinics identified their IPT implementation strategy in a participatory manner. Using routine register data, TST uptake was determined 3 months before and 5 months after the intervention. Records were reviewed to identify IPT/TST uptake and factors associated with IPT initiation among adults living with HIV.</p>
What evidence exists for myofunctional therapy with prefabricated appliances? A systematic review with meta-analyses of randomized trials
<p>Dataset for all analysis in the review</p>
Supplementary Materials for: A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children
<p>Supplemental Tables and Figures for the clinical research article: <strong>A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children</strong></p>
Supplementary file 23 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 22 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 21 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 19 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 17 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 18 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 16 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 15 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 2 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 10 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 3 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 5 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 14 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 4 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 13 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
Supplementary file 9 for the Cochrane review Psychological therapies for people with borderline personality disorder
<p>A Trial Sequential Analysis figure</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.