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1,986 results for “valve”
Ranibizumab in Preventing Failure of Ahmed Valve Glaucoma Surgery
ClinicalTrials.gov study NCT00644280. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - Nested Registry 3/Valve-in-Valve
ClinicalTrials.gov study NCT03225001. IPD Sharing: NO. Countries: 2. Publications: 2.
Safety of the Nocturnal Passy Muir Valve and Impact on Sleep Quality at an LTACH Setting
ClinicalTrials.gov study NCT06229639. IPD Sharing: NO. Countries: 1. Publications: 11.
Dabigatran Etexilate in Patients With Mechanical Heart Valves
ClinicalTrials.gov study NCT01452347. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement
ClinicalTrials.gov study NCT03950440. IPD Sharing: NO. Countries: 1. Publications: 1.
Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)
ClinicalTrials.gov study NCT01796392. IPD Sharing: UNDECIDED. Countries: 4. Publications: 3.
Data from: Separate and combined effects of boat noise and a live crab predator on mussel valve gape behaviour
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Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
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Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis
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Defining the role of the miR-145 – KLF4 – αSMA axis in mitral valvular interstitial cell activation in myxomatous mitral valve prolapse using the canine model
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Data from: Effect of valve opening on starting performance of pump as turbine
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S1PR1 regulates lymphatic valve development and prevents ileitis-independent tertiary lymphoid organ formation
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YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
<p>Lymphatic vasculature is an integral part of digestive, immune and circulatory systems. The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and Vascular Endothelial Growth Factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs). In turn, VEGF-C signaling maintains PROX1 expression in LECs. However, the mechanisms of PROX1/VEGF-C feedback loop remain poorly understood. Whether VEGF-C signaling is necessary for LV and LVV development is also unknown. Here, we report for the first time that VEGF-C signaling is necessary for valve morphogenesis. We have also discovered that the transcriptional co-activators YAP and TAZ are required to maintain PROX1 expression in LVs and LVVs in response to VEGF-C signaling. Deletion of <i>Yap</i> and <i>Taz</i> in the lymphatic vasculature of mouse embryos did not affect the formation of LVs or LVVs, but resulted in the degeneration of these structures. Our results have identified VEGF-C/YAP/TAZ as a critical molecular pathway in valve development.</p>
Data from: Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation
<p>Leaflet thrombosis has been suggested as the reason for the reduced leaflet motion in cases of hypoattenuated leaflet thickening of bioprosthetic aortic valves. This work aimed to estimate the risk of leaflet thrombosis in two post-ViV configurations, using five different numerical approaches. Realistic ViV configurations were calculated by modeling the deployments of the latest version of transcatheter aortic valve devices (Medtronic Evolut PRO, Edwards SAPIEN 3) in the surgical Sorin Mitroflow. Computational fluid dynamics simulations of blood flow followed the dry models. Lagrangian and Eulerian measures of near-wall stagnation were implemented by particle and concentration tracking, respectively, to estimate the thrombogenicity and to predict the risk locations. Most of the numerical approaches indicate on a higher leaflet thrombosis risk in the Edwards SAPIEN 3 device because of its intra-annular implantation. The Eulerian approaches estimated high-risk locations in agreement with the WSS separation points. On the other hand, the Lagrangian approaches predicted high-risk locations at the proximal regions of the leaflets matching the low WSS magnitude regions of both TAVI models and reported clinical and experimental data. The proposed methods can help optimizing future designs of transcatheter aortic valves with minimal thrombotic risks.</p>
FIGURE 16 in Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico
FIGURE 16. Neonesidea schulzi (Hartmann). A–G, specimen 013M; images scanned from contact paper print from over-exposed negative film of over-stained preparation, taken in 1967; magnifications were not recorded. H–I, specimen 767W; J–K, specimen 768F; L, specimen 3080F. A, lateral view of compressed head capsule with EV, showing forehead, atrium, labrum, esophagus, chitinous struts, and EV with ring, plate, and braces; B, A2 claw; C, lateral view of both hemipenes, folded; D–E, DV of both hemipenes and zygum; F–G, EV and plate; H–K, RV and LV exteriors in TL; L, posterior spine of LV and fan-shaped plumose sensilla, by SEM. Scale bar = 50 µm.
FIGURE 14. Neonesidea manningi Maddocks. A–F, holotype male 896M in Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico
FIGURE 14. Neonesidea manningi Maddocks. A–F, holotype male 896M; G–J, specimen 902F; K, specimen 956M; L, unnumbered male specimen; M, specimen 957M. A, A2 claw; B, lateral view of compressed head capsule, with EV and chitinous struts; C, both hemipenes; D–E, RV and LV exteriors in TL; F, AMS of RV; G–H, RV and LV exteriors in TL; I, lateral view of compressed anterior body, with head capsule, labrum, EV, and two food balls; J, genital lobe; K, dorsal view of carapace in RL; L, left lateral view of entire animal in TL; M, plate. Scale bar = 50 µm.
FIGURE 13. A–F in Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico
FIGURE 13. A–F, Neonesidea manningi Maddocks; A, specimen 895M; B–C, specimen 903F; D–E, specimen 900M; F, specimen 906J; all from Ascension Island. G–I, Neonesidea plumulosa Maddocks, holotype specimen 3960M, from French Frigate Shoal, the Hawaiian Islands. J–M, Neonesidea tenera (Brady); J, specimen 3906M; K, specimen 3892F; L, specimen 3905F; M, specimen 3957J; all from French Frigate Shoal, the Hawaiian Islands. A–B, antennal claws; C–G, I, L, EV with ring, plate, bracket, braces, and details of posterior teeth of plate; H, right lateral view of carapace in RL; M, left lateral view of soft body within decalcified RV. Scale bar = 50 µm.
FIGURE 15. Neonesidea omnivaga Maddocks. A–E, specimen 2444F in Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico
FIGURE 15. Neonesidea omnivaga Maddocks. A–E, specimen 2444F; F–L, specimen 2447W. A–B, RV and LV exteriors in TL; C, AMS of LV; D, A2 claw; E, genital lobe; F–G, AMS of RV and LV; H–I, RV and LV exteriors in TL with food ball (f) and unidentifiable fragments of appendages.
FIGURE 12 in Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico
FIGURE 12. Neonesidea longisetosa (Brady). A–O, subfossil specimen 4045M from Belize; P–Q, specimen 1652M from the Bahamas; S, subfossil specimen 4053W from Jamaica. A. A–D, hemipenis, with distal details; E, corner tooth of plate; F–G, VV of plate at high and low focus; H, interior of posteroventral region of RV, showing dry fragments of plate and ring; I–L, diagonal view of plate standing upright within RV interior, from high focus to low focus; M–N, edge view of posterior margin of same plate after removal from valve, showing pyramidal teeth and row of ventral setules, the dorsal surface is up (concave); P–R, hemipenis, with distal details; S, VV of EV with ring and plate. Scale bar = 50 µm.
FIGURE 11 in Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico
FIGURE 11. Neonesidea gerda (Benson and Coleman); A–D, specimen 2397F, from SW Florida; E–G, 4041W; H, specimen 4043W; both from Florida Keys. Neonesidea longisetosa (Brady); I, specimen 4046W; J–P, specimen 4045M; both from Belize. A–B, fragmentary RV and LV exteriors in TL; C, posteroventral flange and sensilla of RV; D, posteroventral marginal denticles and sensilla of LV, but no terminal spine is visible; E–F, RV exterior in TL; G, interior of RV in RL, with fragments of dry appendages and two food balls (f) in domicilium; H–I, DV in RL; J–K, interiors of LV and RV in RL, with fragments of appendages (brown) and two food balls (f); L–M, RV and LV exteriors in TL with fragments of appendages (brown) and two food balls (f); N, posteroventral fringe and terminal spine of RV in TL, with dry food ball (f), hemipenis (h), plate of EV (p), and limb fragments; O, posteroventral region of LV, with marginal denticles, opaque spot, and food ball (f), but no terminal spine is visible; P, interior of posterior region of RV in TL, after removing food ball, showing terminal spine, hemipenis (h), and a limb fragment. Scale bar = 50 µm.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.