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Dataset results
7,518 results for “screenings”
Pooled CRISPR Screening of High-content Cellular Phenotypes by Ghost Cytometry_02
<p>Pooled CRISPR Screening of High-content Cellular Phenotypes by Ghost Cytometry (Macrophage NGS data)</p>
Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans
<p>Fungal pathogens like Candida albicans can cause devastating human disease. Treatment of candidemia is complicated by the high rate of resistance to common antifungal therapies. Additionally, there is host toxicity associated with many antifungal compounds due to the conservation between essential mammalian and fungal proteins. An attractive new approach for antimicrobial development is to target virulence factors: non-essential processes that are required for the organism to cause disease in human hosts. This approach expands the potential target space while reducing the selective pressure towards resistance, as these targets are not essential for viability. In C. albicans, a key virulence factor is the ability to transition to hyphal morphology. We developed a high-throughput image analysis pipeline to distinguish between yeast and filamentous growth in C. albicans at the single cell level. Based on this phenotypic assay, we screened the FDA drug repurposing library of 2,017 compounds for their ability to inhibit filamentation and identified 33 compounds that block the hyphal transition in C. albicans with IC50 values ranging from 0.2 to 150 µM. Multiple compounds showed a phenyl vinyl sulfone chemotype, prompting further analysis. Of these phenyl vinyl sulfones, NSC 697923 displayed the most efficacy, and by selecting for resistant mutants, we identified eIF3 as the target of NSC 697923 in C. albicans. </p>
Preliminary results from Zika virus helicase fragment screening
<p>Preliminary results from Zika virus helicase fragment screening</p>
High Performance Organic Electrochemical Transistors and Logic Circuits Manufactured via a Combination of Screen and Aerosol Jet Printing Techniques
<p>Dataset of the journal article "High Performance Organic Electrochemical Transistors and Logic Circuits Manufactured via a Combination of Screen and Aerosol Jet Printing Techniques" published in <em>Advanced Materials Technologies</em>, 31 May 2022, <a href="https://doi-org.e.bibl.liu.se/10.1002/admt.202200153">https://doi.org/10.1002/admt.202200153</a></p>
GeCKO_v2_CRISPR_drug screens in K562 cells
<p>The data contain raw DNA deep sequencing files for GeCKO-v2 genome scale transduced K562 screens with selected drugs (imatinib, dasatinib, asciminib, tivozanib, AZD1775, mepacrine). For all drug except mepacrine the drug, day 0 and day 17 control samples' files are provided. For mepacrine which was screened separately, a triplicate drug, D15 control sample files are provided. The dates are indicated in the file names. </p>
Figure 1 in Isolation of Bacillus thuricgiecsis from tce state of Amazonas, in Brazil, and screening against Aedes aegypti %Diptera, Culicidae)
Figure 1. Amplification products of gen (A) cry4Ba and (B) cry4Aa of dipteran-specific genes isolated from Bacillus thuringiensis from the state of Amazonas, Brazil.
INFLAMeR: a machine learning algorithm based on large-scale perturbation screening identified new lncRNAs regulating differentiation and survival of leukaemia cells
<p><strong>Abstract</strong></p> <p>Long non-coding RNAs (lncRNAs) are a diverse group of transcripts with poorly understood<br> functionality. To address this gap, we developed INFLAMeR, an advanced machine learning<br> model trained on CRISPRi screening data, to predict functional lncRNAs using comprehensive<br> genetic features. We experimentally validated the predictions by assessing their impact on cell<br> proliferation and anticancer drug resistance. Among the selected lncRNAs, 85% showed<br> significant effects upon knockdown, while low-scoring lncRNAs had no discernible impact.<br> Notably, our study elucidated the functional role of SNHG6 in hematopoietic differentiation.<br> INFLAMeR greatly enhances the prediction of functional lncRNAs, providing valuable insights<br> into their regulatory landscape. By integrating INFLAMeR with experimental validation, we can<br> identify and characterize functional lncRNAs in a cell-type-specific manner, contributing to a<br> deeper understanding of their involvement in cellular processes. Our findings revealed insights<br> into lncRNA biology and a framework for improving the identification of functional lncRNAs.</p>
Dataset for the Tyrosine-protein kinase SYK antibody screening study
<p>This project contains the following underlying data included in a study aiming at characterizing antibodies for Tyrosine-protein kinase SYK. The study is available on Zenodo (https://doi.org/10.5281/zenodo.6566940).</p>
Fig. 1 in Screening of in vitro and in silico α-amylase, α-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives
Fig. 1. Chemical structures of the 23 analysed pure natural and semisynthetic compounds.
Fig. 2 in Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold
Fig. 2. Key COSY, HMBC and ROESY correlations of analogue 5.
Dataset for the SPARC-related modular calcium-binding protein 1(SMOC-1) antibody screening study
<p>This project contains the following underlying data included in a study which characterized seven commercially-available antibodies for SMOC-1. The study is also available on Zenodo<strong> </strong>(https://doi.org/10.5281/zenodo.8277962).</p>
Fig. 1 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 1. Chemical structures of compounds 1–22 isolated from P. oleracea.
Fig. 3 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 3. Crystal structure of compound 2 monohydrate.
Fig. 2 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 2. Key HMBC (H→C) correlations of compounds 1, 3–6, 10, 16, and 17.
WP2T3_DataN3 Screening of tar catalysts for catalytic filter (UNIVAQ)
<p>Raw results of laboratory-scale Study of Nickel-catalyst Pellets Performance for Tar Steam Reforming Obtained from Biomass Gasification (<a href="https://doi.org/10.3303/CET2292110">https://doi.org/10.3303/CET2292110</a>)</p>
Effect of Fee on Attendance in Cervical Cancer Screening
ClinicalTrials.gov study NCT02378324. IPD Sharing: Not stated. Countries: 0. Publications: 8.
CRC Screening Using mSEPT9 (Methylated Septin 9) in Chinese Population
ClinicalTrials.gov study NCT02540850. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screening for Barrett Esophagus
ClinicalTrials.gov study NCT02451124. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Chagas Blood Screening and Confirmatory Assays
ClinicalTrials.gov study NCT00718042. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cutting-edge IMAGING Technologies to Improve the SAFEty and the Sustainability of LUNG Cancer Screening and the Accuracy of Non-invasive Lung Nodules Characterization
ClinicalTrials.gov study NCT06963515. IPD Sharing: NO. Countries: 0. Publications: 9.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.