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2,435
datasets available to search
ShareScore release 0.9.0
Dataset results
2,435 results for “Metastasis”
Hypoxia-induced phase separation of ZHX2 drives 3D chromatin remodeling and cancer metastasis (Hi-C)
GEO Series GSE260880. Homo sapiens. 6 samples. Type: Other.
Hypoxa-actived XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of DNp63 expression and promotes breast cacner metastasis independent HIF1a
GEO Series GSE253833. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Metabolic adaptation of stromal cells to fatty acid drives metastasis of oral squamous cell carcinoma
GEO Series GSE312946. Homo sapiens. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Enforced expression of miR-342 promotes an inflammatory phenotype in liver metastasis-associated macrophages [miRNAseq_1510]
GEO Series GSE274045. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis
GEO Series GSE71629. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C [ChIP-seq]
GEO Series GSE289967. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TH-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been limited due in part, to the lack of animal models harboring bone marrow disease. The widely employed transgenic model, the TH-MYCN mouse, exhibits limited metastasis to this site. Here we establish the first genetic immunocompetent mouse model for metastatic neuroblastoma with enhanced secondary tumors in the bone marrow.
Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis"
<p>Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis"</p><p><strong>Abstract</strong></p><p>Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells accumulate in CRC favoring tumor dissemination. Whether this mechanism progresses also in metastasis is unexplored. Here, we integrated spatial transcriptomics, 3D-microscopy, and multicellular transcriptomics to study the role of cellular senescence in human colorectal liver metastasis (CRLM). We discovered two distinct senescent metastatic cancer cell (SMCC) subtypes, transcriptionally located at the opposite pole of epithelial (e) to mesenchymal (m) transition. SMCCs differ in chemotherapy susceptibility, biological program, and prognostic roles. Mechanistically, epithelial (e)SMCC initiation relies on nucleolar stress, whereby c- myc dependent oncogene hyperactivation induces ribosomal RPL11 accumulation and DNA damage response. In a 2D pre-clinical model, we demonstrated that RPL11 co-localized with HDM2, a p53-specific ubiquitin ligase, leading to senescence activation in (e)SMCCs. On the contrary, mesenchymal (m)SMCCs undergo TGFβ paracrine activation of NOX4-p15 effectors. SMCCs display opposing effects also in the immune regulation of neighboring cells, establishing an immunosuppressive environment or leading to an active immune workflow. Both SMCC signatures are predictive biomarkers whose unbalanced ratio determined the clinical outcome in CRLM and CRC patients. Altogether, we provide a comprehensive new understanding of the role of SMCCs in CRLM and highlight their potential as new therapeutic targets to limit CRLM progression.</p><p> </p>
Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"
<p>This record contains raw data related to article "High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis"</p><p><strong>Abstract</strong></p><p>Patients with colorectal liver metastasis (CLM) present with heterogenous clinical outcomes and improved classification is needed to ameliorate the therapeutic output. Macrophages (Mϕ) hold promise as prognostic classifiers and therapeutic targets. Here, stemming from a single-cell analysis of mononuclear phagocytes infiltrating human CLM, we identified two Mϕ markers associated with distinct populations with opposite clinical relevance. The invasive margin of CLM was enriched in pro-inflammatory monocyte-derived Mϕ (MoMϕ) expressing the monocytic marker SERPINB2, and a more differentiated population, tumor-associated Mϕ (TAM), expressing glycoprotein nonmetastatic melanoma protein B (GPNMB). SERPINB2+ MoMϕ had an early inflammatory profile, whereas GPNMB+ TAMs were enriched in pathways of matrix degradation, angiogenesis, and lipid metabolism and were found closer to the tumor margin, as confirmed by spatial transcriptomics on CLM specimens. In a cohort of patients, a high infiltration of SERPINB2+ cells independently associated with longer disease-free survival (DFS; P = 0.033), whereas a high density of GPNMB+ cells correlated with shorter DFS (P = 0.012) and overall survival (P = 0.002). Cell-cell interaction analysis defined opposing roles for MoMϕ and TAMs, suggesting that SERPINB2+ and GPNMB+ cells are discrete populations of Mϕ and may be exploited for further translation to an immune-based stratification tool. This study provides evidence of how multi-omics approaches can identify nonredundant, clinically relevant markers for further translation to immune-based patient stratification tools and therapeutic targets. GPNMB has been shown to set Mϕ in an immunosuppressive mode. Our high dimensional analyses provide further evidence that GPNMB is a negative prognostic indicator and a potential player in the protumor function of Mϕ populations.</p>
SND1-SMARCA5 interaction strengthened by PIM promoted the proliferation, metastasis and chemoresistance of ESCC
GEO Series GSE281371. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Proteogenomic characterization and comprehensive integrative genomic analysis of human colorectal cancer liver metastasis
GEO Series GSE93286. Homo sapiens. 6 samples. Type: SNP genotyping by SNP array.
Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis
GEO Series GSE115702. Homo sapiens; Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
CircNCOR1 suppresses lymphatic metastasis in bladder cancer
GEO Series GSE191036. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Expression data from breast cancer bone metastasis [MDA-MB 231 scp1833]
GEO Series GSE66204. Mus musculus. 12 samples. Type: Expression profiling by array.
Pancreatic Stellate Cells Promote Growth and Metastasis of Pancreatic Neuroendocrine Tumor
GEO Series GSE167321. Homo sapiens. 4 samples. Type: Expression profiling by array.
Genome-wide copy number analysis for occult lymph node metastasis in oral squamous cell carcinoma
GEO Series GSE31984. Homo sapiens. 60 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
GEO Series GSE197831. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
G-Quadruplex in Long non-coding RNA 00273 acts as microRNA sponge to regulate Metastasis, Cancer Stemness, and Chemoresistance
GEO Series GSE217692. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties
GEO Series GSE277510. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells
GEO Series GSE19281. Homo sapiens. 37 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.