Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,435
datasets available to search
ShareScore release 0.9.0
Dataset results
2,435 results for “Metastasis”
Gene expression analysis of murine 4T1 breast cancer cells derived from primary tumor, lung metastasis and brain metastasis
GEO Series GSE54773. Mus musculus. 9 samples. Type: Expression profiling by array.
Pak1-ATF2 signaling axis induces miR-132 to inhibit hematogenous metastasis
GEO Series GSE84290. Rattus norvegicus; Mus musculus; Homo sapiens. 2 samples. Type: Non-coding RNA profiling by array.
p53-R172H cooperates with Brd4 to induce Csf-1 expression and lung metastasis: H3K27ac profile of mouse ESCC cells with Trp53R172/- or Trp53+/+
GEO Series GSE232757. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis [RIP-Seq]
GEO Series GSE130171. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
HOTAIR-YTHDF3 interaction in promoting breast cancer cell metastasis [RNA-seq]
GEO Series GSE215289. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Tryptophan as a miR team organizer prevents colon cancer liver metastasis [small intestine]
GEO Series GSE212607. synthetic construct; Mus musculus. 4 samples. Type: Non-coding RNA profiling by array.
Affymetrix SNP 6.0 array data from neuroendocrine primary tumor and its metastasis
GEO Series GSE39371. Homo sapiens. 4 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination
GEO Series GSE217342. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
TGF-β and RAS jointly unmask primed enhancers to drive metastasis
GEO Series GSE256020. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Ceramides drive colorectal cancer metastasis through a revival stemness program [ATAC-seq]
GEO Series GSE285872. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis [ATAC-seq]
GEO Series GSE197830. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p (miRNA)
GEO Series GSE157015. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
LINC00365 suppresses breast tumor growth and metastasis by inhibiting the HIF-1α-mediated Warburg effect
GEO Series GSE208407. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"
<p>This record contains raw data related to article "High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis"</p><p><strong>Abstract</strong></p><p>Patients with colorectal liver metastasis (CLM) present with heterogenous clinical outcomes and improved classification is needed to ameliorate the therapeutic output. Macrophages (Mϕ) hold promise as prognostic classifiers and therapeutic targets. Here, stemming from a single-cell analysis of mononuclear phagocytes infiltrating human CLM, we identified two Mϕ markers associated with distinct populations with opposite clinical relevance. The invasive margin of CLM was enriched in pro-inflammatory monocyte-derived Mϕ (MoMϕ) expressing the monocytic marker SERPINB2, and a more differentiated population, tumor-associated Mϕ (TAM), expressing glycoprotein nonmetastatic melanoma protein B (GPNMB). SERPINB2+ MoMϕ had an early inflammatory profile, whereas GPNMB+ TAMs were enriched in pathways of matrix degradation, angiogenesis, and lipid metabolism and were found closer to the tumor margin, as confirmed by spatial transcriptomics on CLM specimens. In a cohort of patients, a high infiltration of SERPINB2+ cells independently associated with longer disease-free survival (DFS; P = 0.033), whereas a high density of GPNMB+ cells correlated with shorter DFS (P = 0.012) and overall survival (P = 0.002). Cell-cell interaction analysis defined opposing roles for MoMϕ and TAMs, suggesting that SERPINB2+ and GPNMB+ cells are discrete populations of Mϕ and may be exploited for further translation to an immune-based stratification tool. This study provides evidence of how multi-omics approaches can identify nonredundant, clinically relevant markers for further translation to immune-based patient stratification tools and therapeutic targets. GPNMB has been shown to set Mϕ in an immunosuppressive mode. Our high dimensional analyses provide further evidence that GPNMB is a negative prognostic indicator and a potential player in the protumor function of Mϕ populations.</p><p> </p>
Bone Metastasis Diminishes Responsiveness to Checkpoint Blockade Immunotherapy by Fostering Osteopontin-producing Osteoclast
<p>The proteomic (Y480A_) and CyTOF (CyTOF_) data of the study.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.