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12,346 results for “derivatives”
Docking of taxane derivatives to the ABCB1 protein.
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raw data - circNR3C2 promote chondrogenic differentiation and cartilage repair of human adipose-derived stem cells via hsa-miR-647/SOX9 pathway
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Spin-Crossover Grafted Monolayer of a Co(II) Terpyridine Derivative Functionalized with Carboxylic Acid Groups
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Semiconductor Porous Hydrogen-Bonded Organic Frameworks Based on Tetrathiafulvalene Derivatives
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Dataset: Evaluation of Physicochemical Properties of Ipsapirone Derivatives Based on Chromatographic and Chemometric Approaches
<p>Dataset for publication</p> <p> </p>
An analytically derived delineation of the West African coastal province based on Bivalves
<p>Supplementary material with distribution data of European and West African marine bivalves</p>
Unprocessed data for the "Deriving Semantics-Aware Fuzzers from Web API Schemas" paper.
<p>Unprocessed data for the "Deriving Semantics-Aware Fuzzers from Web API Schemas" paper.</p>
Geographic range estimates and environmental requirements for the harpy eagle derived from spatial models of current and past distribution
<p>Understanding species-environment relationships is key to defining the spatial structure of species distributions and develop effective conservation plans. However, for many species this baseline information does not exist. With reliable presence data, spatial models that predict geographical ranges and identify environmental processes regulating distribution are a cost-effective and rapid method to achieve this. Yet these spatial models are lacking for many rare and threatened species, particularly in tropical regions. The harpy eagle (<i>Harpia harpyja</i>) is a Neotropical forest raptor of conservation concern with a continental distribution across lowland tropical forests in Central and South America.Currently the harpy eagle faces threats from habitat loss and persecution and is categorised as Near-Threatened by the International Union for the Conservation of Nature (IUCN). Within a point process modelling (PPM) framework, we use presence-only occurrences with climatic and topographical predictors to estimate current and past distributions and define environmental requirements using Ecological Niche Factor Analysis. The current PPM prediction had high calibration accuracy (Continuous Boyce Index = 0.838) and was robust to null expectations (pROC ratio = 1.407). Three predictors contributed 96 % to the PPM prediction, with Climatic Moisture Index the most important (72.1 %), followed by minimum temperature of the warmest month (15.6 %) and Terrain Roughness Index (8.3 %). Assessing distribution in environmental space confirmed the same predictors explaining distribution, along with precipitation in the wettest month. Our reclassified binary model estimated a current range size 11 % smaller than the current IUCN range polygon. Paleoclimatic projections combined with the current model predicted stable climatic refugia in the central Amazon, Guyana, eastern Colombia, and Panama. We propose a data-driven geographical range to complement the current IUCN range estimate, and that despite its continental distribution this tropical forest raptor is highly specialized to specific environmental requirements.</p> <p> </p>
Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia (RNA-seq-P14-HYXvsNOX)
<p><strong>Rationale:</strong> Premature infants exposed to oxygen are at risk for bronchopulmonary dysplasia (BPD), which is characterized by lung growth arrest. Inflammation is important, but the mechanisms remain elusive. Here, we investigated inflammatory pathways and therapeutic targets in severe clinical and experimental BPD.</p> <p><strong>Methods and Results:</strong> First, transcriptomic analysis with in-silico cellular deconvolution identified a lung-intrinsic M1-like-driven cytokine pattern in newborn mice after hyperoxia. These findings were confirmed by gene expression of macrophage-regulating chemokines (Ccl2, Ccl7, Cxcl5) and markers (Il6, Il17A, Mmp12). Second, hyperoxia-activated IL-6/STAT3 signaling was measured in vivo and related to loss of alveolar epithelial type II cells (ATII) as well as increased mesenchymal marker. Il6 null mice exhibited preserved ATII survival, reduced myofibroblasts and improved elastic fiber assembly, thus enabling lung growth and protecting lung function. Pharmacological inhibition of global IL-6 signaling and IL-6 trans-signaling promoted alveolarization and ATII survival after hyperoxia. Third, hyperoxia triggered M1-like polarization, possibly via Klf4; hyperoxia-conditioned medium of macrophages and IL-6 impaired ATII proliferation. Finally, clinical data demonstrate elevated macrophage-related plasma cytokines as potential biomarkers that identify infants receiving oxygen at increased risk of developing BPD. Moreover, macrophage-derived IL6 and active STAT3 were related to loss of epithelial cells in BPD lungs.</p> <p><strong>Conclusion:</strong> We present a novel IL-6-mediated mechanism by which hyperoxia activates macrophages in immature lungs, impairs ATII homeostasis, and disrupts elastic fiber formation, thereby inhibiting lung growth. The data provide evidence that IL-6 trans-signaling could offer an innovative pharmacological target to enable lung growth in severe neonatal chronic lung disease.</p>
Figure 1 from: Bak PG, Belenichev IF, Kucherenko LI, Abramov AV, Khromylоva OV (2021) Morpho-functional indicators changes of rats' myocardium in experimental doxorubicin-induced chronic heart failure and its pharmacological modulation with new 4-amino-1,2,4-triazole derivative. Pharmacia 68(4): 919-925. https://doi.org/10.3897/pharmacia.68.e75298
Figure 1 Hypothetical mechanism of the compound "Hypertril" positive effect on the morpho-functional parameters of rat cardiomyocytes in experimental doxorubicin-induced CHF.
FIGURE 2 in Kalanchoe ×forbesiae (Crassulaceae subfam. Kalanchooideae) derived from K. lubangensis × K. sexangularis: towards improved horticultural material
FIGURE 2. The corolla tubes of Kalanchoe lubangensis are light green. Photograph: Gideon F. Smith.
Figures 3-9 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Figures 3-9 Trissolcus planus (female) 3 habitus, dorsal view (SEM) 4 habitus, lateral view (SEM) 5 female antenna 6 maxillolabial complex (composite drawing) 7 head, frontal view (SEM) 8 head, lateral view (SEM) 9 mesosoma, lateral view (SEM).
Supplementary material 6 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Nexus alignment of the dataset from Talamas et al. (2019) including Trissolcus planus
Supplementary material 5 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Nexus alignment of the dataset from Taekul et al. (2014) including Trissolcus planus
Supplementary material 4 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Phylogenetic reconstruction on the molecular data set of Talamas et al. (2019), Bayesian analysis
Supplementary material 2 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Phylogenetic reconstruction on the partitioned data set of Taekul et al. (2014), ML analysis
Figure 2 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Figure 2 Phylogenetic reconstruction of the molecular data set of Talamas et al. (2019), ML analysis. Posterior probabilities from the BI analysis were plotted besides Felsenstein's bootstrap support and transfer bootstrap expectation.
Figure 1 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Figure 1 Phylogenetic reconstruction of the non-partitioned data set of Taekul et al. (2014) with a degenerated COI alignment, Bayesian analysis. Felsenstein's bootstrap support and transfer bootstrap expectation from the ML analysis were plotted besides the posterior probability.
Figures 18-23 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Figures 18-23 Holotype of Latonius planus (female) 18 habitus, dorsal view 19 head, frontal view 20 habitus, lateral; holotype of Ioseppinella serena (male) 21 mesosoma and metasoma, dorsal view 22 mesosoma, lateral view 23 head, frontal view.
Figures 10-17 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533
Figures 10-17 Trissolcus planus (female) 10 habitus, dorsal view 11 habitus, lateral view 12 fore and hind wings 13 fore wings venation 14, 15 arolium 16 metasoma with exposed tergites, sternites and latero-tergites (composite image) 17 ovipositor assembly (composite image).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.