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7,920 results for “implications”
Full Implication Matrix (IM)
<p>This file contains a full Implication Matrix (IM) created during K. J. Kupilas PhD research "Digital Maturity - Applicability to Research and Development function of international organisations". The original data from the expert interviews were inserted into the LadderUX tool (https://ladderux.org/) and extracted into the Excel file.</p>
Interactions between phenanthrene exposure and historical chemical stress: Implications for fitness and ecological resilience of the sentinel species Daphnia magna
<div> <p>Polycyclic aromatic hydrocarbons (PAHs) arise from incomplete combustion of oil, coal, and gasoline, with lipophilic properties facilitating their widespread distribution and persistence. Due to their biochemical attributes, PAHs can accumulate in animal tissues, potentially causing mutagenic and carcinogenic effects. Since the industrial revolution, PAH concentrations in the environment have risen, with some areas showing levels from 0.159 to 33,090 µg/kg sediment. Despite acute toxicity studies showing adverse effects on freshwater organisms, the long-term impacts and synergistic interactions with other pollutants remain largely unexplored. </p> </div> <div> <p>This study investigates the impact of phenanthrene (PHE), a prominent PAH found in aquatic environments, on <em>Daphnia magna</em>, a species of significant ecological importance in freshwater ecosystems globally, being both a sentinel species for chemical pollution and a keystone organism in freshwater aquatic ecosystems. Leveraging the dormancy of <em>D. magna</em>, which spans decades or even centuries, we exposed strains with diverse histories of chemical contaminant exposure to environmentally relevant concentrations of PHE. Initially, acute exposure experiments were conducted in accordance with OECD guidelines across 16 <em>Daphnia</em> strains, revealing substantial variation in acute toxic responses, with strains naïve to chemical pollutants showing the lowest toxicity. Utilizing the median effect concentration EC10 derived from acute exposures, we assessed the impacts of chronic PHE exposure on the life history traits and ecological endpoints of the 16 strains. To elucidate how historical exposure to other environmental stressors may modulate the toxicity of PHE, temporal populations of <em>D. magna</em> resurrected from a lake with a well-documented century-spanning history of environmental impact were utilized. Our findings demonstrate that PHE exposure induces developmental failure, delays sexual maturation, and reduces adult size in <em>Daphnia</em>. Populations of <em>Daphnia</em> historically exposed to chemical stress exhibited significantly greater fitness impacts compared to naïve populations. This study provides crucial insights into the augmented effects of PAHs interacting with other environmental stressors. </p> </div>
Data from: Endocranial morphology of three early-diverging ceratopsians and implications for the behavior and the evolution of the endocast in ceratopsians
<p>Ceratopsians underwent great changes including the shift of the locomotion mode, enlarged horns and frills, and increased body size. These changes are along with the changes in endocranial morphology and ecology such as the decrease of the flocculus, the hearing range, the olfactory ratio, and the Reptile Encephalization Quotient. However, the endocranial structures and associated ecology of the earliest ceratopsians are still unknown. Here, we reconstructed the endocasts of three early-diverging ceratopsians including the Late Jurassic <em>Yinlong</em>, and the Early Cretaceous <em>Liaoceratops</em> and <em>Psittacosaurus</em>. These ceratopsians display prominent flocculus, large and separate olfactory bulbs, long and high anterior semicircular canal, and long endosseous cochlear duct. Unlike <em>Liaoceratops</em> and <em>Psittacosaurus</em>, <em>Yinlong</em> exhibits relatively stocky semicircular canals and small flocculus. In Ceratopsia, the evolutional patterns of the endocast include the merging and narrowing of the olfactory bulbs, the disappearing flocculus, the reduction of the anterior semicircular canal, the increasing of the angle between two vertical semicircular canals, and the shortening of the cochlear duct. The endocranial structures suggest early-diverging ceratopsians had a high olfactory acuity and were adapted to hearing high frequencies, unlike the condition of late-diverging ceratopsians with lower olfactory acuity and hearing frequency. Reptile Encephalization Quotient suggests that <em>Yinlong</em> and <em>Psittacosaurus</em> were more encephalized than most extant reptiles and late-diverging ceratopsians. The angle of the lateral semicircular canal suggests that heads in ceratopsians display a transition from an upward posture to a downward posture. The relatively upward head posture indicates that early-diverging ceratopsians could feed more selectively such as to eat some leaves.</p>
Simulations of PKA RIα Homodimer Reveal cAMP-coupled Conformational Dynamics of Each Protomer and the Dimer Interface with Functional Implications
<p>Protein kinase A (PKA) is a ubiquitous cAMP-dependent enzyme in mammalian tissues. The inactive PKA holoenzyme disassociates into a homodimer of regulatory (R) subunits and two active catalytic (C) subunits upon cAMP binding to two tandem domains (termed <span>CBD-A</span> <span>and</span> <span>CBD</span>-<span>B</span>) in R subunits. The release of cAMP facilitates reassociation of R and C subunits<span>,</span> resetting PKA to its basal state. The cAMP-mediated structural changes in the activation-termination cycle <span>remain</span> <span>partially</span> <span>understood</span>. The multimeric states of PKA complicate the issue and are particularly <span>less</span> <span>studied</span>. Therefore, we computationally investigate the conformational dynamics of PKA <span>RI</span>a homodimer in different cAMP-bound states. The absence of cAMP in two CBDs affect differently the <span>conformational</span> <span>dynamics</span> of protomers. Moreover, <span>such</span> disparate <span>responses</span> are extended to the dimer interface <span>constituted</span> <span>by</span> <span>the</span> <span>N</span>-<span>terminal</span> <span>helical</span> <span>sub-domains</span> termed N3A motifs. T<span>he removal of cAMP from CBD-A induces large-scale structure</span> changes <span>of individual </span>R subunits <span>towards the holoenzyme state,</span> consist with previous simulations of a single R subunit. <span>Meanwhile</span> <span>it</span> <span>keeps the structural heterogeneity of the </span>N3A-N3A' <span>dimer interface observed in the fully bound state.</span> By contrast, the removal of cAMP from CBD-B does not affect <span>individual </span>R subunits but alters the conformational space of the N3A-N3A' dimer interface. The cAMP-coupled s<span>tructural</span> <span>changes</span> <span>of</span> <span>each</span> <span>protomer</span> <span>and</span> conserved conformational space of <span>the</span> N3A-N3A' <span>dimer</span> <span>interface</span> are essential for t<span>he</span> <span>transition</span> <span>between</span> the fully cAMP-bound R<sub>2</sub> homodimer and the R<sub>2</sub>C<sub>2</sub> holoenzyme as suggested by their crystal structures. Our work provides structural insights into <span>the</span> regulatory mechanism of cAMP in PKA signaling. </p>
Supporting Information for the submitted manuscript by Rajič et al. The origin of tectonic mélanges and implication for the subduction interface processes
<p>Files shared here contain supporting information for the submitted manuscript by Rajič et al.</p> <p>Appendix 1 file contains Text A.1, Tables A.1-2 and Figures A.1-8.</p> <p>Appendix 2 file contains all raw Raman spectra acquired in this study, along with READ ME text file.</p>
Phenotyping data from: Genetics of phenological development and implications for seed yield in lentil
<p>Using a historic collection of Australian lentil varieties released between 1988 and 2019, we show that genetic gain in yield (29 kg ha<sup>-1</sup> yr<sup>-1</sup>) associates with faster reproductive development. A focus on five loci related to reproductive development, the lentil <em>ELF3</em> ortholog <em>Sn</em>, two loci linked to clusters of lentil <em>FT</em> orthologs and two loci without proposed candidates in chromosomes 2 and 5, revealed the potential for introducing novel early flowering alleles into current breeding material for further phenological diversity with potential implications for yield.</p>
Data from U and Th zonation in apatite observed by synchrotron X–ray fluorescence tomography and implications for the (U–Th)/He system Sousa et al 2024
<p>Data from </p> <p><span>U and Th zonation in apatite observed by synchrotron X–ray fluorescence tomography and implications for the (U–Th)/He system</span></p> <p><span>Sousa et al</span></p> <p><span>Geochronology</span></p>
Remagnetization of upper Triassic limestone from the central Lhasa terrane (Tibet): identification, mechanisms, and implications for diagnosing secondary remanent magnetization in carbonate rocks
<p>Raw data and supplementary material for manuscript titleted "Remagnetization of Upper Triassic limestone from the central Lhasa terrane (Tibet): identification, mechanisms, and implications for diagnosing secondary remanent magnetization in carbonate rocks".</p>
Crystallographic Preferred Orientation of Phase D at High Pressure and Temperature: Implications for Seismic Anisotropy in the Mid-mantle
<p> The dataset includes the data of Crystallographic Preferred Orientation of phase D aggregates in this study. It include electron backscatter diffraction (EBSD) mapping data in .cpr and .crc file and transmission two-dimensional X-ray diffraction (2D-XRD) patterns acquired at BL04B1 beamline of synchrotron facility of SPring-8, Hyogo, Japan. </p>
Fig. 4 in The early fossil record of Caturoidea (Halecomorphi: Amiiformes): biogeographic implications
Fig. 4 Stratigraphic distribution of the nannotaxa identified in MPCA 632. Plots von Nannotax 3
Fig. 1 in Multi-Criteria Decision Analysis as a tool to extract fishing footprints: application to small scale fisheries and implications for management in the context of the Maritime Spatial Planning Directive
Fig. 1: Map of the study area.
Figure 3 in Distribution of tick species parasitizing livestock in Sirumalai, The Eastern Ghats of Tamil Nadu, South India and its implications for public health
Figure 3. Images of ticks collected from Sirumalai foot hill villages.
Figure 2 in Distribution of tick species parasitizing livestock in Sirumalai, The Eastern Ghats of Tamil Nadu, South India and its implications for public health
Figure 2. Tick infestation rate in cattle, dogs and sheep.
Figure 1. A in Distribution of tick species parasitizing livestock in Sirumalai, The Eastern Ghats of Tamil Nadu, South India and its implications for public health
Figure 1. A map of the Sirumalai ticks collected areas.
Addressing Observational Gaps in Aerosol Parameters using Machine Learning: Implications to Aerosol Radiative Forcing
<p>This dataset represents Aerosol Optical Depth (AOD), Single Scattering Albedo (SSA), and Absorption Parameter (AP) data over Kanpur, India, sourced from AERONET with initial data gaps of approximately 37%, 62%, and 58% respectively. To reduce these gaps, XGBoost, a machine learning model trained with reanalysis and satellite datasets, was employed with optimized hyperparameter tuning. Using AERONET data for training, XGBoost effectively addressed gaps, improving AOD by 10%, SSA by 23%, and AP by 21%.</p>
Supplementary Dataset for "Grain Size Measurements of the Eolian Stimson Formation, Gale Crater, Mars and Implications for Sand Provenance and Paleoatmospheric Conditions"
<p>Grain size measurements and results in support of "Grain Size Measurements of the Eolian Stimson Formation, Gale Crater, Mars and Implications for Sand Provenance and Paleoatmospheric Conditions".</p> <p>The subfolder "MAHLI images" consists of images taken by the Mars Science Laboratory <em>Curiosity</em> Mars Hand Lens Imager; these images are accesible via the MSL Analyst's Notebook at an.rsl.wustl.edu.</p> <p>The subfolder "ImageJ ROIs" contains .zip files that can be opened with the ImageJ software, available at imagej.nih.gov/ij.</p> <p>The subfolder "GRADISTAT results" contains PDFs with grain size statistics that were created from the data in "Grain size measurements" using the GRADISTAT software, available at https://doi.org/10.1002/esp.261. </p>
Fig. 6 in Multi-Criteria Decision Analysis as a tool to extract fishing footprints: application to small scale fisheries and implications for management in the context of the Maritime Spatial Planning Directive
Fig. 6: Scatterplot matrices for Large (A) and Linear (B) FM functions.
Fig. 8 in Multi-Criteria Decision Analysis as a tool to extract fishing footprints: application to small scale fisheries and implications for management in the context of the Maritime Spatial Planning Directive
Fig. 8: High values of the FP c index as estimated by Local Moran's I test.
Fig. 5 in Multi-Criteria Decision Analysis as a tool to extract fishing footprints: application to small scale fisheries and implications for management in the context of the Maritime Spatial Planning Directive
Fig. 5: Spatial representation of coastal vessels activity indexes (Ac).
Fig. 4 in Multi-Criteria Decision Analysis as a tool to extract fishing footprints: application to small scale fisheries and implications for management in the context of the Maritime Spatial Planning Directive
Fig. 4: Spatial representation of the Coastal fishery suitability index (Sc).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.