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publicJul 2021View details →

Alert burden in pediatric hospitals: A cross-sectional analysis of six academic pediatric health systems using novel metrics

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publicApr 2025View details →

Relationship between c-reactive protein-albumin ratio and prognosis in pediatric patients with severe burns

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publicMar 2020View details →

Modeling the household cost of pediatric malaria treatment in a rural county in Kenya; do non-user fee payments matter? A partial cost of illness analysis

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publicJul 2020View details →

Data from: Pediatric intensive care unit admissions for COVID-19: insights using state-level data

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publicApr 2022View details →

Five year pediatric use of a digital wearable fitness device: lessons from a pilot case study

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opencc-zeroJun 2020View details →

Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses

Objective: This systematic review and meta-analyses assessed seizure outcome following pediatric epilepsy surgery. Methods: MEDLINE, Embase and Cochrane were searched for pediatric epilepsy surgery original research from 1990 to 2017. The outcome was seizure freedom at 12 months or longer follow-up. Using random effects models, the effect sizes for controlled studies, uncontrolled studies on surgery locations (temporal lobe [TL], extra-temporal lobe [ETL] or hemispheric surgery), pathologies, non-lesional epilepsy and incomplete resection were estimated. Meta-regression assessed the relationship between age at surgery, age at seizure onset and seizure outcome. Random-effects network meta-analysis was conducted for surgery locations. Results: 258 studies were included. Surgery achieved higher seizure freedom than medical therapy (OR=6.49 [95%CI: 2.87, 14.70], p<0.001). Seizure freedom declined over time after surgery, from 64.8% (95%CI: 51.2%, 76.4%; p=0.034) at 1 year, to 60.3% (95%CI: 52.9%, 67.4%; p=0.007) at 5 years, and 39.7% (95%CI: 28.4%, 52.2%, p=0.106) at 10 years. Seizure freedom was (i) highest for hemispheric surgery, followed by TL, and ETL surgery; and (ii) highest for tumor, and lower for malformations of cortical development. Seizure freedom was lower for non-lesional than lesional epilepsy (OR=0.54 [95%CI: 0.34, 0.88], p=0.013), and incomplete than complete resection (OR=0.13 [95%CI: 0.08, 0.21], p<0.001). Age at surgery and age at seizure onset were associated with seizure freedom for mixed pathologies and surgery locations, and TL surgery. Conclusion: Epilepsy surgery was more effective than medical therapy to control seizures. Understanding seizure outcomes of different surgery locations, pathologies, non-lesional epilepsy and incomplete resection will assist with pre-surgical counselling.

opencc-zeroAug 2020View details →

Data from: Comparative study of posterior and anterior circulation stroke in childhood – results from the International Pediatric Stroke Study (IPSS)

Objective: This study compares risk factors, clinical presentation, and outcomes after posterior circulation (PCAIS) and anterior circulation arterial ischemic stroke (ACAIS) in neonates and children. Methods: International multicenter observational study including neonates and children up to 18 years of age with arterial ischemic stroke (AIS), comparing clinical and radiological features according to stroke location. Results: Of 2,768 AIS cases, 507 (18%) were located in the posterior circulation, 1,931 (70%) in the anterior circulation, and 330 (12%) involved both. PCAIS was less frequent in neonates compared to children (8.8% versus 22%, p<0.001). Children with PCAIS were older than children with anterior circulation arterial ischemic stroke (ACAIS), (median age 7.8 (IQR 3.1-14) versus 5.1 (IQR 1.5-12) years, p<0.001), and more often presented with headache (54% versus 32%, p<0.001) and a lower PedNIHSS score (4 (IQR 2-8) versus 8 (IQR 3-13), p=0.001). Cervicocephalic artery dissections (CCAD) were more frequent (20% versus 8.5%, p<0.001), while cardioembolic strokes were less frequent (19% versus 32%, p<0.001) in PCAIS. Case fatality rates were equal in both groups (2.9%). PCAIS survivors had a better outcome (normal neurological examination at hospital discharge in 29% versus 21%, p=0.002) than ACAIS survivors, although this trend was only observed in children and not in neonates. Conclusion: PCAIS is less common than ACAIS in both neonates and children. Children with PCAIS are older, have a higher rate of CCAD, lower clinical stroke severity, and better outcome than children with ACAIS.

opencc-zeroDec 2018View details →

Data from: Evaluating a handheld decision support device in pediatric intensive care settings

Objective: To evaluate end-user acceptance and the effect of a commercial handheld decision support device in pediatric intensive care settings. The technology, pac2, was designed to assist nurses in calculating medication dose volumes and infusion rates at the bedside. Materials and Methods: The devices, manufactured by InformMed Inc., were deployed in the pediatric and neonatal intensive care units in two health systems. This mixed methods study assessed end-user acceptance, as well as pac2's effect on the cognitive load associated with bedside dose calculations and the rate of administration errors. Towards this end, data were collected in both pre- and post-implementation phases, including through ethnographic observations, semi-structured interviews, and surveys. Results: Although participants desired a handheld decision support tool such as pac2, their use of pac2 was limited. The nature of the critical care environment, nurses' risk perceptions, and the usability of the technology emerged as major barriers to use. Data did not reveal significant differences in cognitive load or administration errors after pac2 was deployed. Discussion and Conclusion: Despite its potential for reducing adverse medication events, the commercial standalone device evaluated in the study was not used by the nursing participants and thus had very limited effect. Our results have implications for the development and deployment of similar mobile decision support technologies. For example, they suggest that integrating the technology into hospitals' existing IT infrastructure and employing targeted implementation strategies may facilitate nurse acceptance. Ultimately, the usability of the design will be essential to reaping any potential benefits.

opencc-by-4.0Mar 2024View details →

Additional Tables for Defining Factors Important During Colonization And Invasion By The Pediatric Pathogen Kingella kingae

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opencc-by-4.0Apr 2024View details →

Figure 2 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793

Figure 2 OTC drugs containing BAS of plant origin, a derivative or and in a combined composition applied among children aged 0+ - 18 years.

opencc-by-4.0Apr 2024View details →

Figure 1 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793

Figure 1 Distribution of the OTC drugs based on the active substance, which are intended to be applied among pediatric patients.

opencc-by-4.0Apr 2024View details →

Figure 3 from: Hadzhieva BR, Mihaylova AA, Dimitrov MV, Kilova KP (2024) Changes in the list of over-the-counter drugs containing biologically active substances of plant origin which are intended to be applied among pediatric patients in Bulgaria. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e121793

Figure 3 ОТС drugs containing BAS of plant origin, a derivative or and in a combined composition applied among children with various indications.

opencc-by-4.0Oct 2024View details →

Prevalence and risk factors of Acinetobacter baumannii infection in Pediatric Intensive Care Unit at Thammasat University Hospital

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opencc-zeroFeb 2022View details →

VNS and seizure outcomes in pediatric refractory epilepsy: Systematic review and meta-analysis

This data provides supplemental information for the systematic review and Meta-analysis. Supplemental tables report the detailed serach strategy (Supplementary Table 1), details of included studies (Supplementary Table 2), list of excluded studies (Supplementary Table 3), 50% Responder Rate in children with Lennox-Gastaut syndrome after VNS insertion (Supplementary Table 4), 50% Responder Rate in children with Dravet syndrome after VNS insertion (Supplementary Table 5), VNS settings and other seizure outcomes reported in the included studies (Supplementary Table 6) and Studies reporting a formal Quality of life (QOL) assessment in children post VNS implantation (Supplementary Table 7). Supplemental figure 1 (S1) shows the PRISMA flowchart for this systematic review. Supplemental Figure 2 (S2): Determinants of Seizure Outcomes. Multivariable regression showed 50%-RR at last reported follow-up to increase with increasing age of onset of seizures and decrease with the number of ASMs tried before VNS implantation (A). Higher 50%-RR 1-year after VNS implantation was seen in patients with shorter duration of epilepsy and fewer number of ASM trials (B). Decline in 50%-RR at 1 and 2 year follow-up in studies with a higher proportion of males (C). Proportion of seizure free patients at last reported follow-up also decreases with a greater number of ASM trials before VNS implantation (D). [50%-RR: 50% Responder Rate, ASM: Anti-seizure Medication, VNS: Vagus Nerve Stimulator; Bubbles represent individual effect size for studies, lines represent ordinary least squares regression models, and<a name="_Hlk61802391"> </a>the shading represents 95% confidence regions. Supplemental figure 3 (S3): Forest plots for proportion of seizure free patients. Forest plots for proportion of patients with 50% responder rate at 6 months (B), 1 year (C) and 2 years (D) follow-up summarizing the pooled effect estimate and heterogeneity. Supplemental figure 4 (S4): Forest plots for proportion of seizure free patients. Forest plots for proportion of seizure free patients at 6 months (B), 1 year (C) and 2 years (D) follow-up summarizing the pooled effect estimate and heterogeneity.

opencc-zeroJul 2022View details →

Dates of hospitalization patients in the pediatric department of FJMUUH from 2019-2021

<div class="subsection"></div> <div> Data of electronic medical records of patients hospitalised in the paediatric department of Fujian Medical University Union Hospital(FJMUUH) from 21 January 2019 to 20 January 2021 were analysed before and during the COVID-19 pandemic. During the COVID-19 outbreak period, paediatric hospitalisation was reduced by 29.6%, from 1255 to 884. The proportions of infection-related diseases (36.3% (455 cases) vs 20.8% (184 cases)), respiratory system-related diseases (22.5% (283 cases) vs 9.4% (83 cases)); and endocrine, nutritional and metabolic diseases (17.1% (214 cases) vs 9.2% (81 cases)) decreased significantly, whereas that of musculoskeletal and connective tissue diseases increased from 11.0% (138 cases) to 20.1% (178 cases), thereby becoming the most common reason for hospitalisation. The proportions of diseases of the nervous system (12.4% (156 cases) to 18.8% (166 cases)) and mental and behavioural disorders (0.2% (3 cases) to 2.1% (19 cases)) increased significantly. The average length of hospital stay increased after the outbreak (7.57±6.53 vs 8.36±6.87). </div>

opencc-zeroJul 2022View details →

Assessment of Apple Watch Series 6 pulse oximetry and electrocardiograms in a pediatric population

Background: Recent technologic advances have resulted in increased development and utilization of direct-to-consumer cardiac wearable devices with various functionality. This study aimed to assess Apple Watch Series 6 (AW6) pulse oximetry and electrocardiography (ECG) in a cohort of pediatric patients. Results: A total of 84 patients were enrolled over a 5-week period. 68 patients (81%) were placed into the SpO2 and ECG arm, with 16 patients (19%) placed into the SpO2 only arm. Pulse oximetry data was successfully collected in 71/84 (85%) patients and ECG data in 61/68 (90%). ΔSpO2 between modalities was 2.0±2.6% (r=0.76). ΔRR was 43±44msec (r=0.96), ΔPR 19±23msec (r=0.79), ΔQRS 12±13msec (r=0.78), and ΔQT 20±19msec (r=0.9). The AW6 automated rhythm analysis yielded a 75% specificity and found: 1) 40/61 (65.6%) "accurate", 2) 6/61 (9.8%) "accurate with missed findings", 3) 14/61 (23%) "inconclusive", and 4) 1/61 (1.6%) incorrect. Conclusion: The AW6 can accurately measure oxygen saturation when compared to hospital pulse oximeters in pediatric patients and provide good quality single lead ECGs that allow for accurate measurement of RR, PR, QRS, and QT intervals with manual interpretation. The AW6-automated rhythm interpretation algorithm has limitations for smaller pediatric patients and patients with abnormal ECGs.