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12,346 results for “derivatives”
Measured and derived parameters on dissolved thorium and iron in the northern Gulf of Mexico
<p>The raw seawater thorium isotope data used in this study were reported at BCO-DMO (<a href="https://www.bco-dmo.org/dataset/819622">https://www.bco-dmo.org/dataset/819622</a>; <a href="https://www.bco-dmo.org/dataset/819674">https://www.bco-dmo.org/dataset/819674</a>). This supplement was provided for data users to easily access parameters derived from measured parameters. For instance, dissolved Th-232 and Th-230 are measured directly but they are combined to calculate further parameters such as Th-232 flux and Th residence time, as described in our manuscripts. This data is associated with a manuscript under consideration of publication, entitled "Towards Constraining Sources of Lithogenic Metals in the Northern Gulf of Mexico" at the time of publishing this dataset.</p> <p> </p>
The cGPS-derived postseismic displacements related to the 2021 Maduo earthquake in Qinghai province, China
<p>The dataset includes the cGPS-derived postseismic displacements related to the 2021 Maduo earthquake in Qinghai province, China. The tectonic deformations and the seasonal-like deformations are removed from the original GPS time series. Pre-earthquake observations are contained in some of the cGPS data.</p>
Figure 3 from: Drapak І, Zimenkovsky B, Perekhoda L, Yeromina H, Lipakova K, Demchuk I, Rakhimova M (2019) QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants. Pharmacia 66(1): 33-40. https://doi.org/10.3897/pharmacia.66.e35083
Figure 3 The dependence of the observed and predicted antioxidant activity for QSAR-models 5(a) and 15(b) for compounds of the training sample.
Figure 1 from: Drapak І, Zimenkovsky B, Perekhoda L, Yeromina H, Lipakova K, Demchuk I, Rakhimova M (2019) QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants. Pharmacia 66(1): 33-40. https://doi.org/10.3897/pharmacia.66.e35083
Figure 1 Structure of investigated compounds. R= a) H, b) 2-CH3, c) 2,3-(CH3)2, d) 2,4-(CH3)2, e) 2,6-(CH3)2, f) 3,4-(CH3)2, g) 3,5-(CH3)2, h) 2-OCH3, i) 3-OCH3, j) 4-OCH3, k) 2-Cl, l) 3-Cl, m) 4-Cl.
Figure 2 from: Drapak І, Zimenkovsky B, Perekhoda L, Yeromina H, Lipakova K, Demchuk I, Rakhimova M (2019) QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants. Pharmacia 66(1): 33-40. https://doi.org/10.3897/pharmacia.66.e35083
Figure 2 The dependence of observed and predicted antioxidant activities for QSAR-models 2(a) and 3(b) for compounds of the training sample.
Scheme 1 from: Mitkov J, Kondeva-Burdina M, Zlatkov A (2019) Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives. Pharmacia 66(3): 99-106. https://doi.org/10.3897/pharmacia.66.e37263
Scheme 1 General pathway for synthesis of a new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives 6a–i.
Identification of an arthropod molecular target for plant-derived natural repellents
<p><span>Arthropods maintain ecosystem balance, while also contribute to disease spreading. Plant-derived natural repellents represent an ecological way of pest control, but their direct molecular targets in arthropods remain to be further elucidated. Occupying a critical phylogenetic niche in arthropod evolution, scorpions retain an ancestral genetic </span><span>profile</span><span>. Here, using a behavior-guided screening of the <em>Mesobuthus martensii</em> genome, we identif</span><span>ied</span><span> a scorpion transient receptor potential (sTRP1) channel </span><span>that</span><span> senses <em>Cymbopogon</em>-derived natural repellents, while insensitive to the synthetic chemical pesticide DEET. Scrutinizing orthologs of sTRP1 in <em>Drosophila melanogaster</em>, we further demonstrated dTRP</span>ϒ <span>ion channel also as a chemosensory receptor of natural repellents to mediate avoidance behavior. This study sheds light on arthropod molecular targets of natural repellents, exemplifying the arthropod-plant adaptation. It should also help the rational design of insect control strategy and conserve biodiversity.</span></p>
Terrestrial and aerial photos, GCPs and derived point clouds of a sinkhole in Northern Thuringia
<p>Aiming at comparing the results of using either terrestrial or aerial photos for structure from motion photogrammetry of a sinkhole in Northern Thuringia we took these photos in 2017, 2018 and 2019 and surveyed ground control points. Therefore, the data allows both, the comparison of the results of using terrestrial or aerial photos for the 3D reconstruction, and the mulit-year monitoring of geomorphic changes within the sinkhole.</p>
Supplementary material 2 from: Alsaad H, Kubba A, Tahtamouni LH, Hamzah AH (2022) Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3- dimethyl aminobenzoic acid) moiety. Pharmacia 69(2): 415-428. https://doi.org/10.3897/pharmacia.69.e83158
Figure S2
Supplementary material 1 from: Alsaad H, Kubba A, Tahtamouni LH, Hamzah AH (2022) Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3- dimethyl aminobenzoic acid) moiety. Pharmacia 69(2): 415-428. https://doi.org/10.3897/pharmacia.69.e83158
Figure S1
Data from: In vitro cytotoxic, antioxidant, hemolytic and cytoprotective potential of promising ethacrynic acid derivatives
<p><span>Female breast cancer is one of the leading causes of death among patients with cancer and requires a proactive strategy for a cure. Triple-negative breast cancer (</span><span>TNBC) is the most aggressive cancer with a high risk of developing metastases. The purpose of the present study was to screen the pharmacological activities of three promising ethacrynic acid (<strong>EA</strong>) derivatives containing a piperazine moiety (<strong>P3</strong>, <strong>P4</strong>, and <strong>P5</strong>). The <strong>EA</strong> derivatives were tested against MDA-MB-468 cancer cell line as a model for TNBC and MCF7 cancer cell line as a model subtype of luminal breast cancer using the methyl tetrazolium test (MTT). Additionally, the modulation of the glutathione and thioredoxin systems, as well as the antioxidant and cytoprotective potential of each compound, were investigated. Moreover, initial in vitro safety screening was conducted using human blood cells. As a result, <strong>EA</strong> derivatives showed clear dose-dependent antiproliferative activity with high selectivity to cancer cells by orchestrating oxidative stress. Derivative <strong>P3</strong> has the most promising potential for further preclinical investigation, owing to its safety profile and significant cytoprotective and antitumor properties</span><span>.</span></p>
Plant-derived catechols are substrates of TonB-dependent transporters and sensitize Pseudomonas aeruginosa to siderophore-drug conjugates
<p>The dataset contains raw data used to generate the figures of the associated mansucript</p>
Supplementary material 1 from: Yaseen Y, Kubba A, Shihab W, Tahtamouni L (2022) Synthesis, docking study, and structure-activity relationship of novel niflumic acid derivatives acting as anticancer agents by inhibiting VEGFR or EGFR tyrosine kinase activities. Pharmacia 69(3): 595-614. https://doi.org/10.3897/pharmacia.69.e86504
Figures S1, S2, Tables S1, S2
Application of adipose-derived Mesenchymal Stem Cells in an in vivo model of peripheral nerve damage
<p>The aim of this study is to address this issue by performing a detailed analysis of the therapeutic 29 benefits of two treatment options: adipose tissue derived-mesenchymal stem cells (ASCs) and ASC-30 conditioned medium (CM).</p>
Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade
<p class="MsoNormal"><span><strong>Aims/hypothesis</strong></span></p> <p class="MsoNormal"><span> Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have improved the treatment of a broad spectrum of cancers. These immune checkpoint inhibitors (ICIs) reactivate the immune system against tumour cells but can also trigger autoimmune side effects, including type 1 diabetes. Mesenchymal stem cell (MSC) therapy is the most prevalent cell therapy, with tissue-regenerating, anti-fibrosis and immunomodulatory functions provided by the secretome of the cells. Here, we examined whether systemic MSC treatment could prevent the development of type 1 diabetes in a NOD mouse model.</span></p> <p class="MsoNormal"><span><strong>Methods</strong> </span></p> <p class="MsoNormal"><span>The purified PD-L1 monoclonal antibody was administered to induce diabetes in male NOD mice which normally do not develop diabetes. Human adipose-derived MSCs were administered by tail vein injections. T cells, macrophages and monocyte-derived macrophages expressing C-X-C motif chemokine ligand 9 (CXCL9) in pancreatic sections of NOD mice and a cancer patient who developed diabetes following the ICI treatments were analysed by immunofluorescence. Tissue localisation of the injected MSCs, plasma exosome levels and plasma cytokine profiles were also investigated.</span></p> <p class="MsoNormal"><span><strong>Results</strong> </span></p> <p class="MsoNormal"><span>PD-1/PD-L1 blockade induced diabetes in 16 of 25 (64%) NOD mice which received anti-PD-L1 mAb without hMSCs [MSC(−)], whereas MSC administration decreased the incidence to four of 21 (19%) NOD mice which received anti-PD-L1 mAb and hMSCs [MSC(+)]. The PD-1/PD-L1 blockade significantly increased the area of CD3-positive T cells (6.2-fold) and Macrophage-2 (Mac-2) antigen (2.5-fold)- and CXCL9 (40.3-fold)-positive macrophages in the islets. MSCs significantly reduced T cell (45%) and CXCL9-positive macrophage (67%) accumulation in the islets and the occurrence of diabetes. The insulin content (1.9-fold) and islet beta cell area (2.7-fold) were also improved by MSCs. T cells and CXCL9-positive macrophages infiltrated into the intricate gaps between the beta cells in the islets by PD-1/PD-L1 blockade. Such immune cell infiltration was largely prevented by MSCs. The most striking difference was observed in the CXCL9-positive macrophages, which normally did not reside in the beta cell region in the islets but abundantly accumulated in this area after PD-1/PD-L1 blockade and were prevented by MSCs. The CXCL9-positive macrophages were also observed in the islets of a cancer patient who developed diabetes following the administration of ICIs but little was observed in a control patient. Mechanistically, the injected MSCs accumulated in the lung but not in the pancreas and strongly increased plasma exosome levels and changed plasma cytokine profiles.</span></p> <p class="MsoNormal"><span><strong>Conclusions/interpretation</strong></span></p> <p class="MsoNormal"><span> Our results suggest that MSCs can prevent the incidence of diabetes associated with immune checkpoint cancer therapy and may be worth further consideration for new adjuvant cell therapy.</span></p> <p class="MsoNormal"><span><strong>Data availability</strong> </span></p> <p class="MsoNormal"><span>All datasets were deposited to DOI https://doi.org/10.5061/dryad.xwdbrv1fh.</span></p>
Bacterial genera producing compounds related to marine invertebrate-derived compounds.
<p>Data table.</p>
Determining Dust Properties in Protoplanetary Disks: SED-derived Masses and Settling With ALMA
<p>This zip file contains the cornerplots of relevant parameters for the 338 protoplanetary disks modeled in the manuscript "Determining Dust Properties in Protoplanetary Disks: SED-derived Masses and Settling With ALMA" (Rilinger et al. 2022). This version includes the most up-to-date sample of disks. The disk masses are now displayed logarithmically for clarity.</p>
Sanger sequencing of PBMC derived B cells from human healthy donor
<p>Sanger sequencing of 117 PBMC- derived B cells from human healthy donor</p>
Figure 3 from: Al-Mahadeen MM, Jaber AM, Al-Najjar BO (2024) Design, synthesis and biological evaluation of novel 2-hydroxy-1 H-indene-1,3(2 H)-dione derivatives as FGFR1 inhibitors. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e122127
Figure 3 Stick representation of a. Erdafitinib; b. 7b; c. 9a; d. 9b; e. 9c in grey colour, docked within FGFR1 (PDB ID: 5EW8) binding site (green). Generated by Biovia Discovery Studio visualizer®.
Figure 2 from: Al-Mahadeen MM, Jaber AM, Al-Najjar BO (2024) Design, synthesis and biological evaluation of novel 2-hydroxy-1 H-indene-1,3(2 H)-dione derivatives as FGFR1 inhibitors. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e122127
Figure 2 Solid ribbon representation of FGFR1 (PDB ID: 5EW8) with co-crystal (grey) and re-docked (orange) erdafitinib. Generated by Biovia Discovery Studio visualizer®.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.