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10,950 results for “hosting”
Machine learning suggests small size is a key determinant of plasmid host range
<p>Plasmids mediate gene exchange across taxonomic barriers through conjugation, shaping bacterial evolution for billions of years. While plasmid mobility can be harnessed for genetic engineering and drug-delivery applications, rapid plasmid-mediated spread of resistance genes has rendered most clinical antibiotics useless, posing an existential threat to human society. To solve this urgent problem, we must understand how plasmids spread across bacterial communities. Here, we applied machine-learning models to identify features that determine plasmid host range. We assembled an up-to-date dataset of more than thirty thousand bacterial plasmids, separated them into 1125 clusters, and assigned a distribution possibility score, which takes host distribution of each taxonomic rank and the sampling bias of the existing sequencing data into account, for each cluster. Using this score and an optimized plasmid feature pool, we built a model stack consisting of DecisionTreeRegressor, EvoTreeRegressor, and LGBMRegressor as base models and LinearRegressor as a meta-learner. Our analysis reveals that a short sequence length is most important for successful plasmid spread, followed by P-loop NTPases, mobility factors, and <span>β</span>-lactamases. Ours and other recent results suggest that small plasmids broaden their range by evading host defenses and using alternative modes of transfer instead of autonomous conjugation.</p>
Study of orBec® With Prednisone Therapy in the Treatment of Patients With Graft Versus Host Disease (GVHD)
ClinicalTrials.gov study NCT00926575. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remis
ClinicalTrials.gov study NCT00382109. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant
ClinicalTrials.gov study NCT01231412. IPD Sharing: Not stated. Countries: 3. Publications: 2.
A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease
ClinicalTrials.gov study NCT01700036. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase II Trial of Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft-Versus-Host Disease (GVHD) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (MK-7
ClinicalTrials.gov study NCT02663622. IPD Sharing: YES. Countries: 1. Publications: 4.
Bridging Pediatric and Adult Biomarkers in Graft-Versus-Host Disease
ClinicalTrials.gov study NCT02194439. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies
ClinicalTrials.gov study NCT01427881. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Association of Host Genetics With Vaccine Efficacy and Study of Immune Correlates of Risk From a Tetravalent Dengue Vaccine
ClinicalTrials.gov study NCT02827162. IPD Sharing: YES. Countries: 1. Publications: 2.
Efficacy and Safety of a Donor Lymphocyte Preparation Depleted of Functional Host Alloreactive T-cells (ATIR) in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidenti
ClinicalTrials.gov study NCT00967343. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)
ClinicalTrials.gov study NCT00406393. IPD Sharing: YES. Countries: 2. Publications: 1.
Abatacept to Treat Steroid Refractory Chronic Graft Versus Host Disease (cGVHD)
ClinicalTrials.gov study NCT01954979. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Graft-Versus-Host Disease (GVHD) Prophylaxis After Allogeneic Peripheral Blood Hematopoietic Cell Transplantation
ClinicalTrials.gov study NCT00803010. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)
ClinicalTrials.gov study NCT03112603. IPD Sharing: NO. Countries: 31. Publications: 5.
Panobinostat (LBH589): Acute Graft Versus Host Disease (aGVHD) Prevention
ClinicalTrials.gov study NCT02588339. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer
ClinicalTrials.gov study NCT00105001. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Combination of Alemtuzumab and Rituximab at Low-doses in Refractory Chronic Graft-Versus-Host Disease
ClinicalTrials.gov study NCT01042509. IPD Sharing: NO. Countries: 1. Publications: 7.
Bortezomib Plus Tacrolimus and Methotrexate to Prevent Graft Versus Host Disease (GVHD) After Mismatched Allogeneic Non-Myeloablative Blood Stem Cell Transplantation
ClinicalTrials.gov study NCT00369226. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tacrolimus, Sirolimus and Ustekinumab vs. Tacrolimus and Sirolimus for the Prevention of Acute Graft-Versus-Host Disease
ClinicalTrials.gov study NCT01713400. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TAC/MTX vs. TAC/MMF/PTCY for Prevention of Graft-versus-Host Disease and Microbiome and Immune Reconstitution Study (BMT CTN 1703/1801)
ClinicalTrials.gov study NCT03959241. IPD Sharing: YES. Countries: 1. Publications: 3.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.